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Molecular Cancer Therapeutics
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Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

Florence I. Raynaud, Suzanne A. Eccles, Sonal Patel, Sonia Alix, Gary Box, Irina Chuckowree, Adrian Folkes, Sharon Gowan, Alexis De Haven Brandon, Francesca Di Stefano, Angela Hayes, Alan T. Henley, Letitia Lensun, Giles Pergl-Wilson, Anthony Robson, Nahid Saghir, Alexander Zhyvoloup, Edward McDonald, Peter Sheldrake, Stephen Shuttleworth, Melanie Valenti, Nan Chi Wan, Paul A. Clarke and Paul Workman
Florence I. Raynaud
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DOI: 10.1158/1535-7163.MCT-08-1200 Published July 2009
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Article Information

Volume 8, Issue 7, pp. 1725-1738

DOI 
https://doi.org/10.1158/1535-7163.MCT-08-1200
PubMed 
19584227

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received December 19, 2008
  • Revision received April 21, 2009
  • Accepted May 4, 2009
  • Published first July 7, 2009.

Article Versions

  • Previous version (July 7, 2009 - 08:43).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2009 American Association for Cancer Research.

Author Information

  1. Florence I. Raynaud1,
  2. Suzanne A. Eccles1,
  3. Sonal Patel2,
  4. Sonia Alix1,
  5. Gary Box1,
  6. Irina Chuckowree2,
  7. Adrian Folkes2,
  8. Sharon Gowan1,
  9. Alexis De Haven Brandon1,
  10. Francesca Di Stefano1,
  11. Angela Hayes1,
  12. Alan T. Henley1,
  13. Letitia Lensun2,
  14. Giles Pergl-Wilson2,
  15. Anthony Robson2,
  16. Nahid Saghir2,
  17. Alexander Zhyvoloup2,
  18. Edward McDonald1,
  19. Peter Sheldrake1,
  20. Stephen Shuttleworth2,
  21. Melanie Valenti1,
  22. Nan Chi Wan2,
  23. Paul A. Clarke1 and
  24. Paul Workman1
  1. 1Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Haddow and McElwain Laboratories, Sutton, Surrey, United Kingdom and 2Piramed Pharma, Slough, Berkshire, United Kingdom
  1. Requests for reprints:
    Florence Raynaud and Paul Workman, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, United Kingdom. Phone: 44-0-20-8722-4301; Fax: 44-0-20-8722-4324. E-mail: florence.raynaud{at}icr.ac.uk and paul.workman{at}icr.ac.uk
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Molecular Cancer Therapeutics: 8 (7)
July 2009
Volume 8, Issue 7
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Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Florence I. Raynaud, Suzanne A. Eccles, Sonal Patel, Sonia Alix, Gary Box, Irina Chuckowree, Adrian Folkes, Sharon Gowan, Alexis De Haven Brandon, Francesca Di Stefano, Angela Hayes, Alan T. Henley, Letitia Lensun, Giles Pergl-Wilson, Anthony Robson, Nahid Saghir, Alexander Zhyvoloup, Edward McDonald, Peter Sheldrake, Stephen Shuttleworth, Melanie Valenti, Nan Chi Wan, Paul A. Clarke and Paul Workman
Mol Cancer Ther July 1 2009 (8) (7) 1725-1738; DOI: 10.1158/1535-7163.MCT-08-1200

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Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Florence I. Raynaud, Suzanne A. Eccles, Sonal Patel, Sonia Alix, Gary Box, Irina Chuckowree, Adrian Folkes, Sharon Gowan, Alexis De Haven Brandon, Francesca Di Stefano, Angela Hayes, Alan T. Henley, Letitia Lensun, Giles Pergl-Wilson, Anthony Robson, Nahid Saghir, Alexander Zhyvoloup, Edward McDonald, Peter Sheldrake, Stephen Shuttleworth, Melanie Valenti, Nan Chi Wan, Paul A. Clarke and Paul Workman
Mol Cancer Ther July 1 2009 (8) (7) 1725-1738; DOI: 10.1158/1535-7163.MCT-08-1200
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