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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Reviews

  • Reviews
    Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy
    Nathan T. Ihle and Garth Powis
    Mol Cancer Ther January 1 2009 8 (1) 1-9; DOI:10.1158/1535-7163.MCT-08-0801

  • Reviews
    Platinum neurotoxicity pharmacogenetics
    Sarah R. McWhinney, Richard M. Goldberg and Howard L. McLeod
    Mol Cancer Ther January 1 2009 8 (1) 10-16; DOI:10.1158/1535-7163.MCT-08-0840

  • Reviews
    Ixabepilone: targeting βIII-tubulin expression in taxane-resistant malignancies
    Charles Dumontet, Mary Ann Jordan and Francis F.Y. Lee
    Mol Cancer Ther January 1 2009 8 (1) 17-25; DOI:10.1158/1535-7163.MCT-08-0986

Research Articles

  • Research Articles
    Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo
    Renate Burger, Steven Le Gouill, Yu-Tzu Tai, Reshma Shringarpure, Pierfrancesco Tassone, Paola Neri, Klaus Podar, Laurence Catley, Teru Hideshima, Dharminder Chauhan, Eian Caulder, Claire L. Neilan, Kris Vaddi, Jun Li, Martin Gramatzki, Jordan S. Fridman and Kenneth C. Anderson
    Mol Cancer Ther January 1 2009 8 (1) 26-35; DOI:10.1158/1535-7163.MCT-08-0149

  • Research Articles
    UA62784, a novel inhibitor of centromere protein E kinesin-like protein
    Meredith C. Henderson, Yeng-Jeng Y. Shaw, Hong Wang, Haiyong Han, Laurence H. Hurley, Gary Flynn, Robert T. Dorr and Daniel D. Von Hoff
    Mol Cancer Ther January 1 2009 8 (1) 36-44; DOI:10.1158/1535-7163.MCT-08-0789

  • Research Articles
    Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells
    Leslie A. Parsels, Meredith A. Morgan, Daria M. Tanska, Joshua D. Parsels, Brian D. Palmer, R. John Booth, William A. Denny, Christine E. Canman, Alan J. Kraker, Theodore S. Lawrence and Jonathan Maybaum
    Mol Cancer Ther January 1 2009 8 (1) 45-54; DOI:10.1158/1535-7163.MCT-08-0662

  • Research Articles
    Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis
    Tibor Schomber, Adrian Zumsteg, Karin Strittmatter, Ivana Crnic, Helena Antoniadis, Amanda Littlewood-Evans, Jeanette Wood and Gerhard Christofori
    Mol Cancer Ther January 1 2009 8 (1) 55-63; DOI:10.1158/1535-7163.MCT-08-0679

  • Research Articles
    ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer
    James Greenaway, Jack Henkin, Jack Lawler, Roger Moorehead and Jim Petrik
    Mol Cancer Ther January 1 2009 8 (1) 64-74; DOI:10.1158/1535-7163.MCT-08-0864

  • Research Articles
    In vivo activity of novel capecitabine regimens alone and with bevacizumab and oxaliplatin in colorectal cancer xenograft models
    Kenneth Kolinsky, Ben-Quan Shen, Yu-E Zhang, Joseph Kohles, Ute Dugan, Thomas F. Zioncheck, David Heimbrook, Kathryn Packman and Brian Higgins
    Mol Cancer Ther January 1 2009 8 (1) 75-82; DOI:10.1158/1535-7163.MCT-08-0596

  • Research Articles
    Regulation of D-cyclin translation inhibition in myeloma cells treated with mammalian target of rapamycin inhibitors: rationale for combined treatment with extracellular signal–regulated kinase inhibitors and rapamycin
    Patrick Frost, Yijiang Shi, Bao Hoang, Joseph Gera and Alan Lichtenstein
    Mol Cancer Ther January 1 2009 8 (1) 83-93; DOI:10.1158/1535-7163.MCT-08-0254

  • Research Articles
    Peroxisome proliferator-activated receptor γ agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity
    Nathan T. Ihle, Robert Lemos, David Schwartz, Junghwan Oh, Robert J. Halter, Peter Wipf, Lynn Kirkpatrick and Garth Powis
    Mol Cancer Ther January 1 2009 8 (1) 94-100; DOI:10.1158/1535-7163.MCT-08-0714

  • Research Articles
    Synergy between phosphatidylinositol 3-kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung
    Jun Qian, Yong Zou, Jamshedur S.M. Rahman, Bo Lu and Pierre P. Massion
    Mol Cancer Ther January 1 2009 8 (1) 101-109; DOI:10.1158/1535-7163.MCT-08-0973

  • Research Articles
    Rosiglitazone inhibits α4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor γ-independent signals
    Xiaojuan Sun, Jeffrey D. Ritzenthaler, Ying Zheng, Jesse Roman and ShouWei Han
    Mol Cancer Ther January 1 2009 8 (1) 110-118; DOI:10.1158/1535-7163.MCT-08-0719

  • Research Articles
    Intensification therapy with anti-parathyroid hormone-related protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in severe combined immunodeficient mice
    Tadaaki Yamada, Hiroaki Muguruma, Seiji Yano, Kenji Ikuta, Hirokazu Ogino, Soji Kakiuchi, Masaki Hanibuchi, Hisanori Uehara, Yasuhiko Nishioka and Saburo Sone
    Mol Cancer Ther January 1 2009 8 (1) 119-126; DOI:10.1158/1535-7163.MCT-08-0874

  • Research Articles
    Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor
    Kazufumi Sakurama, Kazuhiro Noma, Munenori Takaoka, Yasuko Tomono, Nobuyuki Watanabe, Shinji Hatakeyama, Osamu Ohmori, Seiichi Hirota, Takayuki Motoki, Yasuhiro Shirakawa, Tomoki Yamatsuji, Minoru Haisa, Junji Matsuoka, Noriaki Tanaka and Yoshio Naomoto
    Mol Cancer Ther January 1 2009 8 (1) 127-134; DOI:10.1158/1535-7163.MCT-08-0884

  • Research Articles
    PP2A regulates ionizing radiation–induced apoptosis through Ser46 phosphorylation of p53
    Jun Mi, Elzbieta Bolesta, David L. Brautigan and James M. Larner
    Mol Cancer Ther January 1 2009 8 (1) 135-140; DOI:10.1158/1535-7163.MCT-08-0457

  • Research Articles
    Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68
    Yong A. Yu, Charles Galanis, Yanghee Woo, Nanhai Chen, Qian Zhang, Yuman Fong and Aladar A. Szalay
    Mol Cancer Ther January 1 2009 8 (1) 141-151; DOI:10.1158/1535-7163.MCT-08-0533

  • Research Articles
    Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor
    Hung Huynh, Jonathan W.J. Lee, Pierce K.H. Chow, Van Chanh Ngo, Guo Bin Lew, Irene W.L. Lam, Hock Soo Ong, Alexander Chung and Khee Chee Soo
    Mol Cancer Ther January 1 2009 8 (1) 152-159; DOI:10.1158/1535-7163.MCT-08-0553

  • Research Articles
    Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells
    Helen M. Pettersson, Alexander Pietras, Matilda Munksgaard Persson, Jenny Karlsson, Leif Johansson, Maria C. Shoshan and Sven Påhlman
    Mol Cancer Ther January 1 2009 8 (1) 160-170; DOI:10.1158/1535-7163.MCT-08-0595

  • Research Articles
    Telomerase-specific virotherapy in an animal model of human head and neck cancer
    Oumi Nakajima, Atsuko Matsunaga, Daiju Ichimaru, Yasuo Urata, Toshiyoshi Fujiwara and Koji Kawakami
    Mol Cancer Ther January 1 2009 8 (1) 171-177; DOI:10.1158/1535-7163.MCT-08-0620

  • Research Articles
    CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growth
    Shailesh Singh, Vincent C. Bond, Michael Powell, Udai P. Singh, Harvey L. Bumpers, William E. Grizzle and James W. Lillard Jr.
    Mol Cancer Ther January 1 2009 8 (1) 178-184; DOI:10.1158/1535-7163.MCT-08-0643

  • Research Articles
    Humanized ADEPT comprised of an engineered human purine nucleoside phosphorylase and a tumor targeting peptide for treatment of cancer
    Sepideh Afshar, Tsuneaki Asai and Sherie L. Morrison
    Mol Cancer Ther January 1 2009 8 (1) 185-193; DOI:10.1158/1535-7163.MCT-08-0652

  • Research Articles
    Pharmacogenomic approach for the identification of novel determinants of acquired resistance to oxaliplatin in colorectal cancer
    Anna Martinez-Cardús, Eva Martinez-Balibrea, Eva Bandrés, Raquel Malumbres, Alba Ginés, José Luís Manzano, Miquel Taron, Jesús Garcia-Foncillas and Albert Abad
    Mol Cancer Ther January 1 2009 8 (1) 194-202; DOI:10.1158/1535-7163.MCT-08-0659

  • Research Articles
    Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity
    Ananya Choudhury, Helen Zhao, Farid Jalali, Shahnaz AL Rashid, Jane Ran, Stephane Supiot, Anne E. Kiltie and Robert G. Bristow
    Mol Cancer Ther January 1 2009 8 (1) 203-213; DOI:10.1158/1535-7163.MCT-08-0959

  • Research Articles
    Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation
    David T. Coleman, Rebecca Bigelow and James A. Cardelli
    Mol Cancer Ther January 1 2009 8 (1) 214-224; DOI:10.1158/1535-7163.MCT-08-0722

  • Research Articles
    Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation
    Maria Rius, Carlo Stresemann, Daniela Keller, Manuela Brom, Esther Schirrmacher, Dietrich Keppler and Frank Lyko
    Mol Cancer Ther January 1 2009 8 (1) 225-231; DOI:10.1158/1535-7163.MCT-08-0743

  • Research Articles
    In vivo target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies
    Mikako Ogawa, Celeste A.S. Regino, Peter L. Choyke and Hisataka Kobayashi
    Mol Cancer Ther January 1 2009 8 (1) 232-239; DOI:10.1158/1535-7163.MCT-08-0862

  • Research Articles
    Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay
    Christophe Marchand, Wendy A. Lea, Ajit Jadhav, Thomas S. Dexheimer, Christopher P. Austin, James Inglese, Yves Pommier and Anton Simeonov
    Mol Cancer Ther January 1 2009 8 (1) 240-248; DOI:10.1158/1535-7163.MCT-08-0878

  • Research Articles
    Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets
    James M. Flanagan, Juan M. Funes, Stephen Henderson, Laurence Wild, Nessa Carey and Chris Boshoff
    Mol Cancer Ther January 1 2009 8 (1) 249-260; DOI:10.1158/1535-7163.MCT-08-0636

  • Research Articles
    NS-398, ibuprofen, and cyclooxygenase-2 RNA interference produce significantly different gene expression profiles in prostate cancer cells
    Molykutty John-Aryankalayil, Sanjeewani T. Palayoor, David Cerna, Michael T. Falduto, Scott R. Magnuson and C. Norman Coleman
    Mol Cancer Ther January 1 2009 8 (1) 261-273; DOI:10.1158/1535-7163.MCT-08-0928

Correction

  • Correction
    Effects of IRC-083927 on human tumor growth
    Mol Cancer Ther January 1 2009 8 (1) 274-274; DOI:10.1158/1535-7163.MCT-08-1-COR

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Molecular Cancer Therapeutics: 8 (1)
January 2009
Volume 8, Issue 1
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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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