Table of Contents

Research Articles

• Research Articles

  Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo

  Renate Burger, Steven Le Gouill, Yu-Tzu Tai, Reshma Shringarpure, Pierfrancesco Tassone, Paola Neri, Klaus Podar, Laurence Catley, Teru Hideshima, Dharminder Chauhan, Eian Caulder, Claire L. Neilan, Kris Vaddi, Jun Li, Martin Gramatzki, Jordan S. Fridman and Kenneth C. Anderson

  Mol Cancer Ther January 1 2009 8 (1) 26-35; DOI:10.1158/1535-7163.MCT-08-0149

  
  
• Research Articles

  UA62784, a novel inhibitor of centromere protein E kinesin-like protein

  Meredith C. Henderson, Yeng-Jeng Y. Shaw, Hong Wang, Haiyong Han, Laurence H. Hurley, Gary Flynn, Robert T. Dorr and Daniel D. Von Hoff

  Mol Cancer Ther January 1 2009 8 (1) 36-44; DOI:10.1158/1535-7163.MCT-08-0789

  
  
• Research Articles

  Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

  Leslie A. Parsels, Meredith A. Morgan, Daria M. Tanska, Joshua D. Parsels, Brian D. Palmer, R. John Booth, William A. Denny, Christine E. Canman, Alan J. Kraker, Theodore S. Lawrence and Jonathan Maybaum

  Mol Cancer Ther January 1 2009 8 (1) 45-54; DOI:10.1158/1535-7163.MCT-08-0662

  
  
• Research Articles

  Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis

  Tibor Schomber, Adrian Zumsteg, Karin Strittmatter, Ivana Crnic, Helena Antoniadis, Amanda Littlewood-Evans, Jeanette Wood and Gerhard Christofori

  Mol Cancer Ther January 1 2009 8 (1) 55-63; DOI:10.1158/1535-7163.MCT-08-0679

  
  
• Research Articles

  ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer

  James Greenaway, Jack Henkin, Jack Lawler, Roger Moorehead and Jim Petrik

  Mol Cancer Ther January 1 2009 8 (1) 64-74; DOI:10.1158/1535-7163.MCT-08-0864

  
  
• Research Articles

  In vivo activity of novel capecitabine regimens alone and with bevacizumab and oxaliplatin in colorectal cancer xenograft models

  Kenneth Kolinsky, Ben-Quan Shen, Yu-E Zhang, Joseph Kohles, Ute Dugan, Thomas F. Zioncheck, David Heimbrook, Kathryn Packman and Brian Higgins

  Mol Cancer Ther January 1 2009 8 (1) 75-82; DOI:10.1158/1535-7163.MCT-08-0596

  
  
• Research Articles

  Regulation of D-cyclin translation inhibition in myeloma cells treated with mammalian target of rapamycin inhibitors: rationale for combined treatment with extracellular signal–regulated kinase inhibitors and rapamycin

  Patrick Frost, Yijiang Shi, Bao Hoang, Joseph Gera and Alan Lichtenstein

  Mol Cancer Ther January 1 2009 8 (1) 83-93; DOI:10.1158/1535-7163.MCT-08-0254

  
  
• Research Articles

  Peroxisome proliferator-activated receptor γ agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity

  Nathan T. Ihle, Robert Lemos, David Schwartz, Junghwan Oh, Robert J. Halter, Peter Wipf, Lynn Kirkpatrick and Garth Powis

  Mol Cancer Ther January 1 2009 8 (1) 94-100; DOI:10.1158/1535-7163.MCT-08-0714

  
  
• Research Articles

  Synergy between phosphatidylinositol 3-kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung

  Jun Qian, Yong Zou, Jamshedur S.M. Rahman, Bo Lu and Pierre P. Massion

  Mol Cancer Ther January 1 2009 8 (1) 101-109; DOI:10.1158/1535-7163.MCT-08-0973

  
  
• Research Articles

  Rosiglitazone inhibits α4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor γ-independent signals

  Xiaojuan Sun, Jeffrey D. Ritzenthaler, Ying Zheng, Jesse Roman and ShouWei Han

  Mol Cancer Ther January 1 2009 8 (1) 110-118; DOI:10.1158/1535-7163.MCT-08-0719

  
  
• Research Articles

  Intensification therapy with anti-parathyroid hormone-related protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in severe combined immunodeficient mice

  Tadaaki Yamada, Hiroaki Muguruma, Seiji Yano, Kenji Ikuta, Hirokazu Ogino, Soji Kakiuchi, Masaki Hanibuchi, Hisanori Uehara, Yasuhiko Nishioka and Saburo Sone

  Mol Cancer Ther January 1 2009 8 (1) 119-126; DOI:10.1158/1535-7163.MCT-08-0874

  
  
• Research Articles

  Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor

  Kazufumi Sakurama, Kazuhiro Noma, Munenori Takaoka, Yasuko Tomono, Nobuyuki Watanabe, Shinji Hatakeyama, Osamu Ohmori, Seiichi Hirota, Takayuki Motoki, Yasuhiro Shirakawa, Tomoki Yamatsuji, Minoru Haisa, Junji Matsuoka, Noriaki Tanaka and Yoshio Naomoto

  Mol Cancer Ther January 1 2009 8 (1) 127-134; DOI:10.1158/1535-7163.MCT-08-0884

  
  
• Research Articles

  PP2A regulates ionizing radiation–induced apoptosis through Ser46 phosphorylation of p53

  Jun Mi, Elzbieta Bolesta, David L. Brautigan and James M. Larner

  Mol Cancer Ther January 1 2009 8 (1) 135-140; DOI:10.1158/1535-7163.MCT-08-0457

  
  
• Research Articles

  Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68

  Yong A. Yu, Charles Galanis, Yanghee Woo, Nanhai Chen, Qian Zhang, Yuman Fong and Aladar A. Szalay

  Mol Cancer Ther January 1 2009 8 (1) 141-151; DOI:10.1158/1535-7163.MCT-08-0533

  
  
• Research Articles

  Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor

  Hung Huynh, Jonathan W.J. Lee, Pierce K.H. Chow, Van Chanh Ngo, Guo Bin Lew, Irene W.L. Lam, Hock Soo Ong, Alexander Chung and Khee Chee Soo

  Mol Cancer Ther January 1 2009 8 (1) 152-159; DOI:10.1158/1535-7163.MCT-08-0553

  
  
• Research Articles

  Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells

  Helen M. Pettersson, Alexander Pietras, Matilda Munksgaard Persson, Jenny Karlsson, Leif Johansson, Maria C. Shoshan and Sven Påhlman

  Mol Cancer Ther January 1 2009 8 (1) 160-170; DOI:10.1158/1535-7163.MCT-08-0595

  
  
• Research Articles

  Telomerase-specific virotherapy in an animal model of human head and neck cancer

  Oumi Nakajima, Atsuko Matsunaga, Daiju Ichimaru, Yasuo Urata, Toshiyoshi Fujiwara and Koji Kawakami

  Mol Cancer Ther January 1 2009 8 (1) 171-177; DOI:10.1158/1535-7163.MCT-08-0620

  
  
• Research Articles

  CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growth

  Shailesh Singh, Vincent C. Bond, Michael Powell, Udai P. Singh, Harvey L. Bumpers, William E. Grizzle and James W. Lillard Jr.

  Mol Cancer Ther January 1 2009 8 (1) 178-184; DOI:10.1158/1535-7163.MCT-08-0643

  
  
• Research Articles

  Humanized ADEPT comprised of an engineered human purine nucleoside phosphorylase and a tumor targeting peptide for treatment of cancer

  Sepideh Afshar, Tsuneaki Asai and Sherie L. Morrison

  Mol Cancer Ther January 1 2009 8 (1) 185-193; DOI:10.1158/1535-7163.MCT-08-0652

  
  
• Research Articles

  Pharmacogenomic approach for the identification of novel determinants of acquired resistance to oxaliplatin in colorectal cancer

  Anna Martinez-Cardús, Eva Martinez-Balibrea, Eva Bandrés, Raquel Malumbres, Alba Ginés, José Luís Manzano, Miquel Taron, Jesús Garcia-Foncillas and Albert Abad

  Mol Cancer Ther January 1 2009 8 (1) 194-202; DOI:10.1158/1535-7163.MCT-08-0659

  
  
• Research Articles

  Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity

  Ananya Choudhury, Helen Zhao, Farid Jalali, Shahnaz AL Rashid, Jane Ran, Stephane Supiot, Anne E. Kiltie and Robert G. Bristow

  Mol Cancer Ther January 1 2009 8 (1) 203-213; DOI:10.1158/1535-7163.MCT-08-0959

  
  
• Research Articles

  Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation

  David T. Coleman, Rebecca Bigelow and James A. Cardelli

  Mol Cancer Ther January 1 2009 8 (1) 214-224; DOI:10.1158/1535-7163.MCT-08-0722

  
  
• Research Articles

  Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation

  Maria Rius, Carlo Stresemann, Daniela Keller, Manuela Brom, Esther Schirrmacher, Dietrich Keppler and Frank Lyko

  Mol Cancer Ther January 1 2009 8 (1) 225-231; DOI:10.1158/1535-7163.MCT-08-0743

  
  
• Research Articles

  In vivo target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies

  Mikako Ogawa, Celeste A.S. Regino, Peter L. Choyke and Hisataka Kobayashi

  Mol Cancer Ther January 1 2009 8 (1) 232-239; DOI:10.1158/1535-7163.MCT-08-0862

  
  
• Research Articles

  Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay

  Christophe Marchand, Wendy A. Lea, Ajit Jadhav, Thomas S. Dexheimer, Christopher P. Austin, James Inglese, Yves Pommier and Anton Simeonov

  Mol Cancer Ther January 1 2009 8 (1) 240-248; DOI:10.1158/1535-7163.MCT-08-0878

  
  
• Research Articles

  Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets

  James M. Flanagan, Juan M. Funes, Stephen Henderson, Laurence Wild, Nessa Carey and Chris Boshoff

  Mol Cancer Ther January 1 2009 8 (1) 249-260; DOI:10.1158/1535-7163.MCT-08-0636

  
  
• Research Articles

  NS-398, ibuprofen, and cyclooxygenase-2 RNA interference produce significantly different gene expression profiles in prostate cancer cells

  Molykutty John-Aryankalayil, Sanjeewani T. Palayoor, David Cerna, Michael T. Falduto, Scott R. Magnuson and C. Norman Coleman

  Mol Cancer Ther January 1 2009 8 (1) 261-273; DOI:10.1158/1535-7163.MCT-08-0928