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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

Cover image

Cover image expansion

The structure of NVP-BEZ235 alone (top) or docked in the catalytic site of PI3Kα (bottom). The model was generated using the coordinates of known PI3Kγ crystal structures. All possible orientations were considered to determine which one was the most consistent with the available structure-activity relationship, in particular with regard to the importance of the hydrogen bond acceptor nitrogen atoms present in the chemical structure of the inhibitor for high potency. For details, see Maira et al., in this issue.

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Molecular Cancer Therapeutics: 7 (7)
July 2008
Volume 7, Issue 7
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Issue Highlights

  • Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
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Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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