Genistein promotes the re-organization of PODs to a dot-like pattern. The diffused microspeckled-like distribution of PML observed in APL cell line NB4 cells (DMSO-upper panels) was converted to a more centralized dot-like distribution after genistein treatment (genistein-upper panels). The effect of genistein on re-organization of PODs was very similar to that of RA (Retinoic acid panels). Similarly, the diffused nucleo-cytoplasmic distribution of N-CoR (DMSO-lower panels) was changed to a predominantly nuclear distribution pattern and exhibited significant co-localization with PML after genistein treatment (genistein-lower panels). For details, see Ng et al. in this issue.