Table of Contents

Research Articles

• Research Articles

  Bevacizumab plus 5-fluorouracil induce growth suppression in the CWR-22 and CWR-22R prostate cancer xenografts

  Huynh Hung

  Mol Cancer Ther August 1 2007 6 (8) 2149-2157; DOI:10.1158/1535-7163.MCT-07-0071

  
  
• Research Articles

  A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor–dependent tumor growth in vivo

  Qun-sheng Ji, Mark J. Mulvihill, Maryland Rosenfeld-Franklin, Andrew Cooke, Lixin Feng, Gilda Mak, Matthew O'Connor, Yan Yao, Caroline Pirritt, Elizabeth Buck, Alexandra Eyzaguirre, Lee D. Arnold, Neil W. Gibson and Jonathan A. Pachter

  Mol Cancer Ther August 1 2007 6 (8) 2158-2167; DOI:10.1158/1535-7163.MCT-07-0070

  
  
• Research Articles

  Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity

  Fumiyuki Yamasaki, Dongwei Zhang, Chandra Bartholomeusz, Tamotsu Sudo, Gabriel N. Hortobagyi, Kaoru Kurisu and Naoto T. Ueno

  Mol Cancer Ther August 1 2007 6 (8) 2168-2177; DOI:10.1158/1535-7163.MCT-06-0514

  
  
• Research Articles

  Selective cell death of oncogenic Akt-transduced brain cancer cells by etoposide through reactive oxygen species–mediated damage

  Se-Yeong Oh, Young-Woo Sohn, Jong-Whi Park, Hyo-Jung Park, Hye-Min Jeon, Tae-Kyung Kim, Joong-Seob Lee, Ji-Eun Jung, Xun Jin, Yong Gu Chung, Young-Ki Choi, Seungkwon You, Jang-Bo Lee and Hyunggee Kim

  Mol Cancer Ther August 1 2007 6 (8) 2178-2187; DOI:10.1158/1535-7163.MCT-07-0111

  
  
• Research Articles

  Rapamycin inhibits multiple stages of c-Neu/ErbB2–induced tumor progression in a transgenic mouse model of HER2-positive breast cancer

  Jonathan D. Mosley, John T. Poirier, Darcie D. Seachrist, Melissa D. Landis and Ruth A. Keri

  Mol Cancer Ther August 1 2007 6 (8) 2188-2197; DOI:10.1158/1535-7163.MCT-07-0235

  
  
• Research Articles

  Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts

  Neil R. Smith, Neil H. James, Ian Oakley, Anna Wainwright, Clive Copley, Jane Kendrew, Lynsey M. Womersley, Juliane M. Jürgensmeier, Stephen R. Wedge and Simon T. Barry

  Mol Cancer Ther August 1 2007 6 (8) 2198-2208; DOI:10.1158/1535-7163.MCT-07-0142

  
  
• Research Articles

  AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models

  Barry R. Davies, Armelle Logie, Jennifer S. McKay, Paul Martin, Samantha Steele, Richard Jenkins, Mark Cockerill, Sue Cartlidge and Paul D. Smith

  Mol Cancer Ther August 1 2007 6 (8) 2209-2219; DOI:10.1158/1535-7163.MCT-07-0231

  
  
• Research Articles

  Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth

  Honglin Hao, Vanessa M. Muniz-Medina, Heena Mehta, Nancy E. Thomas, Vladimir Khazak, Channing J. Der and Janiel M. Shields

  Mol Cancer Ther August 1 2007 6 (8) 2220-2229; DOI:10.1158/1535-7163.MCT-06-0728

  
  
• Research Articles

  Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo

  Ghenet K. Hagos, Robert E. Carroll, Tatiana Kouznetsova, Qian Li, Violeta Toader, Patricia A. Fernandez, Steven M. Swanson and Gregory R.J. Thatcher

  Mol Cancer Ther August 1 2007 6 (8) 2230-2239; DOI:10.1158/1535-7163.MCT-07-0069

  
  
• Research Articles

  Therapeutic targeting of nuclear receptor corepressor misfolding in acute promyelocytic leukemia cells with genistein

  Angela Ping Ping Ng, Dawn Sijin Nin, Jek Howe Fong, Divya Venkataraman, Chien-Shing Chen and Matiullah Khan

  Mol Cancer Ther August 1 2007 6 (8) 2240-2248; DOI:10.1158/1535-7163.MCT-06-0705

  
  
• Research Articles

  CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling

  Chris R. Evelyn, Susan M. Wade, Qin Wang, Mei Wu, Jorge A. Iñiguez-Lluhí, Sofia D. Merajver and Richard R. Neubig

  Mol Cancer Ther August 1 2007 6 (8) 2249-2260; DOI:10.1158/1535-7163.MCT-06-0782

  
  
• Research Articles

  Anticancer medicines in development: assessment of bioactivity profiles within the National Cancer Institute anticancer screening data

  David G. Covell, Ruili Huang and Anders Wallqvist

  Mol Cancer Ther August 1 2007 6 (8) 2261-2270; DOI:10.1158/1535-7163.MCT-06-0787

  
  
• Research Articles

  Differentially expressed genes in radioresistant nasopharyngeal cancer cells: gp96 and GDF15

  Joseph Tung-Chieh Chang, Shih-Hsuan Chan, Chien-Yu Lin, Ting-Yang Lin, Hung-Ming Wang, Chun-Ta Liao, Tzu-Hao Wang, Li-Yu Lee and Ann-Joy Cheng

  Mol Cancer Ther August 1 2007 6 (8) 2271-2279; DOI:10.1158/1535-7163.MCT-06-0801

  
  
• Research Articles

  Pharmacodynamic and pharmacokinetic study of chronic low-dose metronomic cyclophosphamide therapy in mice

  Urban Emmenegger, Yuval Shaked, Shan Man, Guido Bocci, Ivan Spasojevic, Giulio Francia, Andrew Kouri, Robert Coke, William Cruz-Munoz, Susan M. Ludeman, O. Michael Colvin and Robert S. Kerbel

  Mol Cancer Ther August 1 2007 6 (8) 2280-2289; DOI:10.1158/1535-7163.MCT-07-0181

  
  
• Research Articles

  The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity

  Sheila Miknyoczki, Hong Chang, Jennifer Grobelny, Sonya Pritchard, Candace Worrell, Natalie McGann, Mark Ator, Jean Husten, James Deibold, Robert Hudkins, Allison Zulli, Ralph Parchment and Bruce Ruggeri

  Mol Cancer Ther August 1 2007 6 (8) 2290-2302; DOI:10.1158/1535-7163.MCT-07-0062

  
  
• Research Articles

  The antipsychotic drug trifluoperazine inhibits DNA repair and sensitizes non–small cell lung carcinoma cells to DNA double-strand break–induced cell death

  Anya G. Polischouk, Åsa Holgersson, Dali Zong, Bo Stenerlöw, Hanna L. Karlsson, Lennart Möller, Kristina Viktorsson and Rolf Lewensohn

  Mol Cancer Ther August 1 2007 6 (8) 2303-2309; DOI:10.1158/1535-7163.MCT-06-0402

  
  
• Research Articles

  Alteration of dihydropyrimidine dehydrogenase expression by IFN-α affects the antiproliferative effects of 5-fluorouracil in human hepatocellular carcinoma cells

  Shinji Oie, Mayumi Ono, Hiroto Fukushima, Fumihito Hosoi, Hirohisa Yano, Yuichiro Maruyama, Masamichi Kojiro, Tadafumi Terada, Kazuyuki Hirano, Michihiko Kuwano and Yuji Yamada

  Mol Cancer Ther August 1 2007 6 (8) 2310-2318; DOI:10.1158/1535-7163.MCT-06-0281

  
  
• Research Articles

  A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-κB, COX-1, and COX-2

  Ann S.J. Yeoh, Rachel J. Gibson, Eric E.K. Yeoh, Joanne M. Bowen, Andrea M. Stringer, Kar A. Giam and Dorothy M.K. Keefe

  Mol Cancer Ther August 1 2007 6 (8) 2319-2327; DOI:10.1158/1535-7163.MCT-07-0113

  
  
• Research Articles

  A bifunctional colchicinoid that binds to the androgen receptor

  Nima Sharifi, Ernest Hamel, Markus A. Lill, Prabhakar Risbood, Charles T. Kane Jr., Md Tafazzal Hossain, Amanda Jones, James T. Dalton and William L. Farrar

  Mol Cancer Ther August 1 2007 6 (8) 2328-2336; DOI:10.1158/1535-7163.MCT-07-0163

  
  
• Research Articles

  A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells

  Arnold H. van der Luit, Stefan R. Vink, Jeffrey B. Klarenbeek, Daniel Perrissoud, Eric Solary, Marcel Verheij and Wim J. van Blitterswijk

  Mol Cancer Ther August 1 2007 6 (8) 2337-2345; DOI:10.1158/1535-7163.MCT-07-0202

  
  
• Research Articles

  ²¹³Bi-induced death of HSC45-M2 gastric cancer cells is characterized by G₂ arrest and up-regulation of genes known to prevent apoptosis but induce necrosis and mitotic catastrophe

  Christof Seidl, Matthias Port, Klaus-Peter Gilbertz, Alfred Morgenstern, Frank Bruchertseifer, Markus Schwaiger, Barbara Röper, Reingard Senekowitsch-Schmidtke and Michael Abend

  Mol Cancer Ther August 1 2007 6 (8) 2346-2359; DOI:10.1158/1535-7163.MCT-07-0132

  
  
• Research Articles

  Development of a fluorescence-based assay to screen antiviral drugs against Kaposi's sarcoma–associated herpesvirus

  Tamara K. Nun, David J. Kroll, Nicholas H. Oberlies, Djaja D. Soejarto, Ryan J. Case, Pius Piskaut, Teatulohi Matainaho, Chelsey Hilscher, Ling Wang, Dirk P. Dittmer, Shou-Jian Gao and Blossom Damania

  Mol Cancer Ther August 1 2007 6 (8) 2360-2370; DOI:10.1158/1535-7163.MCT-07-0108

  
  
• Research Articles

  Therapeutic ultrasound facilitates antiangiogenic gene delivery and inhibits prostate tumor growth

  Maayan Duvshani-Eshet, Ofra Benny, Avigail Morgenstern and Marcelle Machluf

  Mol Cancer Ther August 1 2007 6 (8) 2371-2382; DOI:10.1158/1535-7163.MCT-07-0019