Table of Contents

Research Articles

• Research Articles

  Platelet-derived growth factor receptor-α: a novel therapeutic target in human hepatocellular cancer

  Peggy Stock, Dulabh Monga, Xinping Tan, Amanda Micsenyi, Nick Loizos and Satdarshan P.S. Monga

  Mol Cancer Ther July 1 2007 6 (7) 1932-1941; DOI:10.1158/1535-7163.MCT-06-0720

  
  
• Research Articles

  Intratumoral expression of respiratory syncytial virus fusion protein in combination with cytokines encoded by adenoviral vectors as in situ tumor vaccine for colorectal cancer

  Dennis Hoffmann, Wibke Bayer, Thomas Grunwald and Oliver Wildner

  Mol Cancer Ther July 1 2007 6 (7) 1942-1950; DOI:10.1158/1535-7163.MCT-06-0790

  
  
• Research Articles

  Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells

  Ellen Weisberg, Andrew L. Kung, Renee D. Wright, Daisy Moreno, Laurie Catley, Arghya Ray, Leigh Zawel, Mary Tran, Jan Cools, Gary Gilliland, Constantine Mitsiades, Douglas W. McMillin, Jingrui Jiang, Elizabeth Hall-Meyers and James D. Griffin

  Mol Cancer Ther July 1 2007 6 (7) 1951-1961; DOI:10.1158/1535-7163.MCT-06-0810

  
  
• Research Articles

  Inhibition of c-Src expression and activation in malignant pleural mesothelioma tissues leads to apoptosis, cell cycle arrest, and decreased migration and invasion

  Anne S. Tsao, Dandan He, Babita Saigal, Suyu Liu, J. Jack Lee, Srinivasa Bakkannagari, Nelson G. Ordonez, Waun Ki Hong, Ignacio Wistuba and Faye M. Johnson

  Mol Cancer Ther July 1 2007 6 (7) 1962-1972; DOI:10.1158/1535-7163.MCT-07-0052

  
  
• Research Articles

  Nuclear factor-κB activation: a molecular therapeutic target for estrogen receptor–negative and epidermal growth factor receptor family receptor–positive human breast cancer

  Sindhu Singh, Qian Shi, Shannon T. Bailey, Marek J. Palczewski, Arthur B. Pardee, J. Dirk Iglehart and Debajit K. Biswas

  Mol Cancer Ther July 1 2007 6 (7) 1973-1982; DOI:10.1158/1535-7163.MCT-07-0063

  
  
• Research Articles

  Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-κB signaling

  Christine L. Curry, Laura L. Reed, Eugenia Broude, Todd E. Golde, Lucio Miele and Kimberly E. Foreman

  Mol Cancer Ther July 1 2007 6 (7) 1983-1992; DOI:10.1158/1535-7163.MCT-07-0093

  
  
• Research Articles

  Ovarian cancer cell–derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis

  Thorsten Hagemann, Stephen C. Robinson, Richard G. Thompson, Kellie Charles, Hagen Kulbe and Frances R. Balkwill

  Mol Cancer Ther July 1 2007 6 (7) 1993-2002; DOI:10.1158/1535-7163.MCT-07-0118

  
  
• Research Articles

  ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo

  Laura Rosanò, Valeriana Di Castro, Francesca Spinella, Maria Rita Nicotra, Pier Giorgio Natali and Anna Bagnato

  Mol Cancer Ther July 1 2007 6 (7) 2003-2011; DOI:10.1158/1535-7163.MCT-07-0151

  
  
• Research Articles

  Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity

  Rakesh Kumar, Victoria B. Knick, Sharon K. Rudolph, Jennifer H. Johnson, Renae M. Crosby, Ming-Chih Crouthamel, Teresa M. Hopper, Charles G. Miller, Laura E. Harrington, James A. Onori, Robert J. Mullin, Tona M. Gilmer, Anne T. Truesdale, Andrea H. Epperly, Amogh Boloor, Jeffrey A. Stafford, Deirdre K. Luttrell and Mui Cheung

  Mol Cancer Ther July 1 2007 6 (7) 2012-2021; DOI:10.1158/1535-7163.MCT-07-0193

  
  
• Research Articles

  Preventive effects of Polyphenon E on urinary bladder and mammary cancers in rats and correlations with serum and urine levels of tea polyphenols

  Ronald A. Lubet, Chung S. Yang, Mao-Jung Lee, Yukihiko Hara, Izet M. Kapetanovic, James A. Crowell, Vernon E. Steele, M. Margaret Juliana and Clinton J. Grubbs

  Mol Cancer Ther July 1 2007 6 (7) 2022-2028; DOI:10.1158/1535-7163.MCT-07-0058

  
  
• Research Articles

  The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway

  Heath A. Elrod, Yi-Dan Lin, Ping Yue, Xuerong Wang, Sagar Lonial, Fadlo R. Khuri and Shi-Yong Sun

  Mol Cancer Ther July 1 2007 6 (7) 2029-2038; DOI:10.1158/1535-7163.MCT-07-0004

  
  
• Research Articles

  TNF-α–based accentuation in cryoinjury—dose, delivery, and response

  Raghav Goel, David Swanlund, James Coad, Guilio F. Paciotti and John C. Bischof

  Mol Cancer Ther July 1 2007 6 (7) 2039-2047; DOI:10.1158/1535-7163.MCT-06-0676

  
  
• Research Articles

  Suppression of RelB-mediated manganese superoxide dismutase expression reveals a primary mechanism for radiosensitization effect of 1α,25-dihydroxyvitamin D₃ in prostate cancer cells

  Yong Xu, Fang Fang, Daret K. St. Clair, Sajni Josson, Pradoldej Sompol, Ivan Spasojevic and William H. St. Clair

  Mol Cancer Ther July 1 2007 6 (7) 2048-2056; DOI:10.1158/1535-7163.MCT-06-0700

  
  
• Research Articles

  A novel synthetic compound that interrupts androgen receptor signaling in human prostate cancer cells

  Shan Lu, Amy Wang, Shan Lu and Zhongyun Dong

  Mol Cancer Ther July 1 2007 6 (7) 2057-2064; DOI:10.1158/1535-7163.MCT-06-0735

  
  
• Research Articles

  Trastuzumab causes antibody-dependent cellular cytotoxicity–mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance

  Márk Barok, Jorma Isola, Zsuzsanna Pályi-Krekk, Péter Nagy, István Juhász, György Vereb, Päivikki Kauraniemi, Anita Kapanen, Minna Tanner, György Vereb and János Szöllösi

  Mol Cancer Ther July 1 2007 6 (7) 2065-2072; DOI:10.1158/1535-7163.MCT-06-0766

  
  
• Research Articles

  2-Methoxy antimycin reveals a unique mechanism for Bcl-x_L inhibition

  Pamela S. Schwartz, Michael K. Manion, Christine B. Emerson, John S. Fry, Craig M. Schulz, Ian R. Sweet and David M. Hockenbery

  Mol Cancer Ther July 1 2007 6 (7) 2073-2080; DOI:10.1158/1535-7163.MCT-06-0767

  
  
• Research Articles

  The HLA A*0201–restricted hTERT_540–548 peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor

  Marco A. Purbhoo, Yi Li, Deborah H. Sutton, Joanna E. Brewer, Emma Gostick, Giovanna Bossi, Bruno Laugel, Ruth Moysey, Emma Baston, Nathaniel Liddy, Brian Cameron, Alan D. Bennett, Rebecca Ashfield, Anita Milicic, David A. Price, Brendan J. Classon, Andrew K. Sewell and Bent K. Jakobsen

  Mol Cancer Ther July 1 2007 6 (7) 2081-2091; DOI:10.1158/1535-7163.MCT-07-0092

  
  
• Research Articles

  Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein

  Kazuhiro Katayama, Sho Yoshioka, Satomi Tsukahara, Junko Mitsuhashi and Yoshikazu Sugimoto

  Mol Cancer Ther July 1 2007 6 (7) 2092-2102; DOI:10.1158/1535-7163.MCT-07-0148

  
  
• Research Articles

  TRAIL therapy in non–small cell lung cancer cells: sensitization to death receptor–mediated apoptosis by proteasome inhibitor bortezomib

  Jens Voortman, Tatiana P. Resende, Mohamed A.I. Abou El Hassan, Giuseppe Giaccone and Frank A.E. Kruyt

  Mol Cancer Ther July 1 2007 6 (7) 2103-2112; DOI:10.1158/1535-7163.MCT-07-0167

  
  
• Research Articles

  Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities

  Karen Liby, Tadashi Honda, Charlotte R. Williams, Renee Risingsong, Darlene B. Royce, Nanjoo Suh, Albena T. Dinkova-Kostova, Katherine K. Stephenson, Paul Talalay, Chitra Sundararajan, Gordon W. Gribble and Michael B. Sporn

  Mol Cancer Ther July 1 2007 6 (7) 2113-2119; DOI:10.1158/1535-7163.MCT-07-0180

  
  
• Research Articles

  Novel antagonists of the thioesterase domain of human fatty acid synthase

  Robyn D. Richardson and Jeffrey W. Smith

  Mol Cancer Ther July 1 2007 6 (7) 2120-2126; DOI:10.1158/1535-7163.MCT-07-0187

  
  
• Research Articles

  Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21^WAF1/CIP1 expression with rapamycin

  Chun-Te Chiang, Tzong-Der Way and Jen-Kun Lin

  Mol Cancer Ther July 1 2007 6 (7) 2127-2138; DOI:10.1158/1535-7163.MCT-07-0107