Table of Contents

Research Articles: Therapeutics, Targets, and Development

• Research Articles: Therapeutics, Targets, and Development

  Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents

  Yasunori Yoshimoto, Christina K. Augustine, Jin S. Yoo, Patricia A. Zipfel, M. Angelica Selim, Scott K. Pruitt, Henry S. Friedman, Francis Ali-Osman and Douglas S. Tyler

  Mol Cancer Ther May 1 2007 6 (5) 1492-1500; DOI:10.1158/1535-7163.MCT-06-0718

  
  
• Research Articles: Therapeutics, Targets, and Development

  Inhibition of topoisomerase IIα and G₂ cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials

  Lei Guo, Xiaojun Liu, Kiyohiro Nishikawa and William Plunkett

  Mol Cancer Ther May 1 2007 6 (5) 1501-1508; DOI:10.1158/1535-7163.MCT-06-0780

  
  
• Research Articles: Therapeutics, Targets, and Development

  Development of two novel benzoylphenylurea sulfur analogues and evidence that the microtubule-associated protein tau is predictive of their activity in pancreatic cancer

  Antonio Jimeno, Gurulingappa Hallur, Audrey Chan, Xiangfeng Zhang, George Cusatis, Fonda Chan, Preeti Shah, Rongbing Chen, Ernest Hamel, Elizabeth Garrett-Mayer, Saeed Khan and Manuel Hidalgo

  Mol Cancer Ther May 1 2007 6 (5) 1509-1516; DOI:10.1158/1535-7163.MCT-06-0592

  
  
• Research Articles: Therapeutics, Targets, and Development

  Fasudil inhibits vascular endothelial growth factor–induced angiogenesis in vitro and in vivo

  Limei Yin, Ken-ichirou Morishige, Toshifumi Takahashi, Kae Hashimoto, Seiji Ogata, Seiji Tsutsumi, Keiko Takata, Tsuyoshi Ohta, Jun Kawagoe, Kazuhiro Takahashi and Hirohisa Kurachi

  Mol Cancer Ther May 1 2007 6 (5) 1517-1525; DOI:10.1158/1535-7163.MCT-06-0689

  
  
• Research Articles: Therapeutics, Targets, and Development

  Classification of anti-estrogens according to intramolecular FRET effects on phospho-mutants of estrogen receptor α

  Wilbert Zwart, Alexander Griekspoor, Mariska Rondaij, Desiree Verwoerd, Jacques Neefjes and Rob Michalides

  Mol Cancer Ther May 1 2007 6 (5) 1526-1533; DOI:10.1158/1535-7163.MCT-06-0750

  
  
• Research Articles: Therapeutics, Targets, and Development

  Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy

  Lourdes A. Gomez, Alicia de las Pozas, Teresita Reiner, Kerry Burnstein and Carlos Perez-Stable

  Mol Cancer Ther May 1 2007 6 (5) 1534-1543; DOI:10.1158/1535-7163.MCT-06-0727

  
  
• Research Articles: Therapeutics, Targets, and Development

  Cellular FLICE-inhibitory protein regulates chemotherapy-induced apoptosis in breast cancer cells

  Katherine M.A. Rogers, Michelle Thomas, Leeona Galligan, Timothy R. Wilson, Wendy L. Allen, Hidekazu Sakai, Patrick G. Johnston and Daniel B. Longley

  Mol Cancer Ther May 1 2007 6 (5) 1544-1551; DOI:10.1158/1535-7163.MCT-06-0673

  
  
• Research Articles: Therapeutics, Targets, and Development

  Enhanced tumor cell kill by combined treatment with a small-molecule antagonist of mouse double minute 2 and adenoviruses encoding p53

  Harm C.A. Graat, Jan E. Carette, Frederik H.E. Schagen, Lyubomir T. Vassilev, Winald R. Gerritsen, Gertjan J.L. Kaspers, Paul I.J.M. Wuisman and Victor W. van Beusechem

  Mol Cancer Ther May 1 2007 6 (5) 1552-1561; DOI:10.1158/1535-7163.MCT-06-0631

  
  
• Research Articles: Therapeutics, Targets, and Development

  5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNFα-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling

  Rong-Ying Su, Yee Chao, Tsai-Yu Chen, Duen-Yi Huang and Wan-Wan Lin

  Mol Cancer Ther May 1 2007 6 (5) 1562-1571; DOI:10.1158/1535-7163.MCT-06-0800

  
  
• Research Articles: Therapeutics, Targets, and Development

  A bioactive withanolide Tubocapsanolide A inhibits proliferation of human lung cancer cells via repressing Skp2 expression

  Hui-Chiu Chang, Fang-Rong Chang, Yu-Chu Wang, Mei-Ren Pan, Wen-Chun Hung and Yang-Chang Wu

  Mol Cancer Ther May 1 2007 6 (5) 1572-1578; DOI:10.1158/1535-7163.MCT-06-0812

  
  
• Research Articles: Therapeutics, Targets, and Development

  ZD1839 induces p15^INK4b and causes G₁ arrest by inhibiting the mitogen-activated protein kinase/extracellular signal–regulated kinase pathway

  Makoto Koyama, Youichirou Matsuzaki, Shingo Yogosawa, Toshiaki Hitomi, Mayumi Kawanaka and Toshiyuki Sakai

  Mol Cancer Ther May 1 2007 6 (5) 1579-1587; DOI:10.1158/1535-7163.MCT-06-0814

  
  
• Research Articles: Therapeutics, Targets, and Development

  Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator–activated receptor γ agonists in colon cancer cells

  Sudhakar Chintharlapalli, Sabitha Papineni, Indira Jutooru, Alan McAlees and Stephen Safe

  Mol Cancer Ther May 1 2007 6 (5) 1588-1598; DOI:10.1158/1535-7163.MCT-07-0022

  
  
• Research Articles: Therapeutics, Targets, and Development

  Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak

  Young-Ae Kim, Dong Xiao, Hui Xiao, Anna A. Powolny, Karen L. Lew, Megan L. Reilly, Yan Zeng, Zhou Wang and Shivendra V. Singh

  Mol Cancer Ther May 1 2007 6 (5) 1599-1609; DOI:10.1158/1535-7163.MCT-06-0754

  
  
• Research Articles: Therapeutics, Targets, and Development

  Expression of human glutathione S-transferase P1 mediates the chemosensitivity of osteosarcoma cells

  Gangxiong Huang, Lisa Mills and Laura L. Worth

  Mol Cancer Ther May 1 2007 6 (5) 1610-1619; DOI:10.1158/1535-7163.MCT-06-0580

  
  
• Research Articles: Therapeutics, Targets, and Development

  Differential regulation of vascular endothelial growth factor by Akt and mammalian target of rapamycin inhibitors in cell lines derived from childhood solid tumors

  Raushan T. Kurmasheva, Franklin C. Harwood and Peter J. Houghton

  Mol Cancer Ther May 1 2007 6 (5) 1620-1628; DOI:10.1158/1535-7163.MCT-06-0646

  
  
• Research Articles: Therapeutics, Targets, and Development

  Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles

  Priti S. Hegde, David Rusnak, Melissa Bertiaux, Krystal Alligood, Jay Strum, Robert Gagnon and Tona M. Gilmer

  Mol Cancer Ther May 1 2007 6 (5) 1629-1640; DOI:10.1158/1535-7163.MCT-05-0399

  
  
• Research Articles: Therapeutics, Targets, and Development

  Shikonin circumvents cancer drug resistance by induction of a necroptotic death

  Weidong Han, Ling Li, Shuang Qiu, Qinghua Lu, Qiangrong Pan, Ying Gu, Jianhong Luo and Xun Hu

  Mol Cancer Ther May 1 2007 6 (5) 1641-1649; DOI:10.1158/1535-7163.MCT-06-0511

  
  
• Research Articles: Therapeutics, Targets, and Development

  Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation

  Jonathan A.F. Hannay, Juehui Liu, Quan-Sheng Zhu, Svetlana V. Bolshakov, Lan Li, Peter W.T. Pisters, Alexander J.F. Lazar, Dihua Yu, Raphael E. Pollock and Dina Lev

  Mol Cancer Ther May 1 2007 6 (5) 1650-1660; DOI:10.1158/1535-7163.MCT-06-0636

  
  
• Research Articles: Therapeutics, Targets, and Development

  Transactivator of transcription–tagged cell cycle and apoptosis regulatory protein-1 peptides suppress the growth of human breast cancer cells in vitro and in vivo

  Liyue Zhang, Edi Levi, Pralay Majumder, Yingjie Yu, Amro Aboukameel, Jianhua Du, Hu Xu, Ramzi Mohammad, James S. Hatfield, Anil Wali, Volkan Adsay, Adhip P.N. Majumdar and Arun K. Rishi

  Mol Cancer Ther May 1 2007 6 (5) 1661-1672; DOI:10.1158/1535-7163.MCT-06-0653

  
  
• Research Articles: Therapeutics, Targets, and Development

  Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line

  Anna Herman-Antosiewicz, Hui Xiao, Karen L. Lew and Shivendra V. Singh

  Mol Cancer Ther May 1 2007 6 (5) 1673-1681; DOI:10.1158/1535-7163.MCT-06-0807