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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

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Proapoptotic synergy between the antiestrogen, 4-hydroxytamoxifen (4-OHT) and the plant toxin, persin is mediated via an upregulation of Bim mRNA in human breast cancer cells. A combination of nontoxic concentrations of persin (2.76 μmol/L) or 4-OHT (7.5 μmol/L) leads to a significant enhancement of apoptosis compared to single agent treatment, and this is associated with the increase in Bim mRNA shown. Knock-down of Bim expression with specific siRNA abrogates this synergistic response. For details, see Roberts et al. in this issue.

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Molecular Cancer Therapeutics: 6 (10)
October 2007
Volume 6, Issue 10
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Issue Highlights

  • Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism
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Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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