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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

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ΚΒ3-1 cells selected for resistance to paclitaxel in the presence of a P-glycoprotein reversal agent display a mutation in β.-tubulin at Asp26Glu. Computational modeling associated with the single point mutation in tubulin is consistent with differing resistance observed between paclitaxel and other taxanes as depicted by detailed interaction models of paclitaxel and docetaxel in wild type β.-tubulin (top) and paclitaxel in Asp26Glu mutant β.-tubulin (bottom). In this issue, Hari and coworkers consider the resistance as a function of both impaired drug binding and microtubule instability.

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Molecular Cancer Therapeutics: 5 (2)
February 2006
Volume 5, Issue 2
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Issue Highlights

  • Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules
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Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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