Article Figures & Data
Figures
- Figure 1.
Mean survival time of mice inoculated with various numbers of murine L1210 leukemia cells injected i.p. or i.v. These data form the basis for the in vivo bioassay method for determining the number of L1201 cells surviving after treatment of L1210 tumor–bearing mice with therapy. From these survival curves, it was determined that (i) from i.p. inoculation, L1210 cell generation time = 0.55 day; lethal number of L1210 cells = 1.5 × 109; and (ii) from i.v. inoculation, L1210 cell generation time = 0.43 day (adapted from ref. 13).
- Figure 2.
Schematic representation of the calculation of tumor growth delay in days is shown illustrating the log-linear relationship between tumor volume increase and time. Tumor growth delay is usually calculated when control tumors reach a volume of 500 or 1,000 mm3.
- Figure 3.
Survival of EMT-6 mouse mammary tumor cells located in various tissues of BALB/c mice treated with a single dose of cyclophosphamide (100, 300, or 500 mg/kg). The mice were treated with cyclophosphamide on day 7 post tumor cell implant and the tissues were excised on day 8. Plating efficiency of tumor cells from untreated control mice was set at a surviving fraction of 1.0. There is a log-linear relationship between tumor cell killing and drug dose. The large variation in response of the tumor cells to the drug depending on tissue location is evident (adapted from ref. 26).
- Figure 4.
Growth delay of the mouse Lewis lung carcinoma produced by a range of doses of gemcitabine (i.p., days 7, 10, and 13) alone or with navelbine (15 mg/kg total dose; 10 mg/kg on day 7 and 5 mg/kg on day 14). The shaded area is the envelope of additivity calculated from dose-response curves for gemcitabine and navelbine administered as single agents using the isobologram method. Bars, SE (adapted from ref. 88).
Volume 5, Issue 10
