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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

Cover image

Cover image expansion

Apical polarity of the t-SNARE syntaxin 3 may have implications for cancer immunotherapy. In situ immunofluorescence analysis reveals that syntaxin 3 (green) is localized to the apical surface of prostatic epithelial cells lining the luminal interface of the gland while E-cadherin (red) is localized in its typical basolateral pattern (top figure). Polarity of these antigens is similar in cultured MDCK cells expressing exogenous rat syntaxin 3 (bottom figure). Disrupting microtubule integrity with commonly used chemotherapeutic drugs alters the localization of syntaxin 3 and the polarized delivery of at least some apical transmembrane proteins, including an important tumor associated antigen overexpressed in most cases of prostate cancer. For details, see Christiansen et al. in this issue.

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Molecular Cancer Therapeutics: 5 (10)
October 2006
Volume 5, Issue 10
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Issue Highlights

  • Differing effects of microtubule depolymerizing and stabilizing chemotherapeutic agents on t-SNARE–mediated apical targeting of prostate-specific membrane antigen
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Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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