Table of Contents

Article

• Article

  AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model

  I-Fen Chen, Fu Ou-Yang, Jen-Yu Hung, Jaw-Ching Liu, Hongying Wang, Shao-Chun Wang, Ming-Feng Hou, Gabriel N. Hortobagyi and Mien-Chie Hung

  Mol Cancer Ther January 1 2006 5 (1) 1-7; DOI:10.1158/1535-7163.MCT-05-0310

  
  
• Article

  Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas

  Tin Lap Lee, Jason Yeh, Carter Van Waes and Zhong Chen

  Mol Cancer Ther January 1 2006 5 (1) 8-19; DOI:10.1158/1535-7163.MCT-05-0069

  
  
• Article

  Restoration of p53 function for selective Fas-mediated apoptosis in human and rat glioma cells in vitro and in vivo by a p53 COOH-terminal peptide

  Patrick B. Senatus, Yin Li, Christopher Mandigo, Gwen Nichols, Gaetan Moise, Yuehua Mao, Melandee D. Brown, Richard C. Anderson, Andrew T. Parsa, Paul W. Brandt-Rauf, Jeffrey N. Bruce and Robert L. Fine

  Mol Cancer Ther January 1 2006 5 (1) 20-28; DOI:10.1158/1535-7163.MCT-05-0181

  
  
• Article

  Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisons

  Hiroshi Y. Yamada and Gary J. Gorbsky

  Mol Cancer Ther January 1 2006 5 (1) 29-38; DOI:10.1158/1535-7163.MCT-05-0126

  
  
• Article

  Modulation of nuclear factor E2-related factor 2–mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin

  Guoxiang Shen, Changjiang Xu, Rong Hu, Mohit R. Jain, Avantika Gopalkrishnan, Sujit Nair, Mou-Tuan Huang, Jefferson Y. Chan and Ah-Ng Tony Kong

  Mol Cancer Ther January 1 2006 5 (1) 39-51; DOI:10.1158/1535-7163.MCT-05-0293

  
  
• Article

  Targeted delivery of methotrexate to epidermal growth factor receptor–positive brain tumors by means of cetuximab (IMC-C225) dendrimer bioconjugates

  Gong Wu, Rolf F. Barth, Weilian Yang, Shinji Kawabata, Liwen Zhang and Kari Green-Church

  Mol Cancer Ther January 1 2006 5 (1) 52-59; DOI:10.1158/1535-7163.MCT-05-0325

  
  
• Article

  The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization

  Danhua Xiao, Atsuko Deguchi, Gregg G. Gundersen, Bert Oehlen, Lee Arnold and I. Bernard Weinstein

  Mol Cancer Ther January 1 2006 5 (1) 60-67; DOI:10.1158/1535-7163.MCT-05-0260

  
  
• Article

  Enhancement of DNA topoisomerase I inhibitor–induced apoptosis by ursodeoxycholic acid

  Tadashi Ikegami, Yasushi Matsuzaki, Maryam Al Rashid, Susan Ceryak, Yining Zhang and Bernard Bouscarel

  Mol Cancer Ther January 1 2006 5 (1) 68-79; DOI:10.1158/1535-7163.MCT-05-0107

  
  
• Article

  Improvement by solid dispersion of the bioavailability of KRN633, a selective inhibitor of VEGF receptor-2 tyrosine kinase, and identification of its potential therapeutic window

  Naoki Matsunaga, Kazuhide Nakamura, Atsushi Yamamoto, Eri Taguchi, Hiromi Tsunoda and Kazumi Takahashi

  Mol Cancer Ther January 1 2006 5 (1) 80-88; DOI:10.1158/1535-7163.MCT-05-0202

  
  
• Article

  Antitumor efficacy of a urokinase activation–dependent anthrax toxin

  Birgitte Rønø, John Rømer, Shihui Liu, Thomas H. Bugge, Stephen H. Leppla and Paul E.G. Kristjansen

  Mol Cancer Ther January 1 2006 5 (1) 89-96; DOI:10.1158/1535-7163.MCT-05-0163

  
  
• Article

  New enzyme for reductive cancer chemotherapy, YieF, and its improvement by directed evolution

  Yoram Barak, Stephen H. Thorne, David F. Ackerley, Susan V. Lynch, Christopher H. Contag and A. Matin

  Mol Cancer Ther January 1 2006 5 (1) 97-103; DOI:10.1158/1535-7163.MCT-05-0365

  
  
• Article

  Cetuximab preclinical antitumor activity (monotherapy and combination based) is not predicted by relative total or activated epidermal growth factor receptor tumor expression levels

  Robert Wild, Krista Fager, Christine Flefleh, David Kan, Ivan Inigo, Stephen Castaneda, Feng (Roger) Luo, Amy Camuso, Kelly McGlinchey and William C. Rose

  Mol Cancer Ther January 1 2006 5 (1) 104-113; DOI:10.1158/1535-7163.MCT-05-0259

  
  
• Article

  Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function

  Yang Feng, Zhongyu Zhu, Xiaodong Xiao, Vidita Choudhry, J. Carl Barrett and Dimiter S. Dimitrov

  Mol Cancer Ther January 1 2006 5 (1) 114-120; DOI:10.1158/1535-7163.MCT-05-0252

  
  
• Article

  Differential competitive resistance to methylating versus chloroethylating agents among five O⁶-alkylguanine DNA alkyltransferases in human hematopoietic cells

  Aparecida Maria Fontes, Brian M. Davis, Lance P. Encell, Karen Lingas, Dimas Tadeu Covas, Marco Antonio Zago, Lawrence A. Loeb, Anthony E. Pegg and Stanton L. Gerson

  Mol Cancer Ther January 1 2006 5 (1) 121-128; DOI:10.1158/1535-7163.MCT-05-0236

  
  
• Article

  Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor in human endothelial cells

  Seiji Kondo, Noriko Tanaka, Satoshi Kubota, Yoshiki Mukudai, Gen Yosimichi, Toshio Sugahara and Masaharu Takigawa

  Mol Cancer Ther January 1 2006 5 (1) 129-137; DOI:10.1158/1535-7163.MCT-05-0097

  
  
• Article

  Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy

  Yean Kit Lee, Crescent R. Isham, Scott H. Kaufman and Keith C. Bible

  Mol Cancer Ther January 1 2006 5 (1) 138-148; DOI:10.1158/1535-7163.MCT-05-0235

  
  
• Article

  Antitumor efficacy of CD137 ligation is maximized by the use of a CD137 single-chain Fv–expressing whole-cell tumor vaccine compared with CD137-specific monoclonal antibody infusion

  Hongtao Zhang, Keith L. Knutson, Karl Erik Hellstrom, Mary L. Disis and Ingegerd Hellstrom

  Mol Cancer Ther January 1 2006 5 (1) 149-155; DOI:10.1158/1535-7163.MCT-05-0206

  
  
• Article

  Enhanced antiproliferative effects of alkoxyalkyl esters of cidofovir in human cervical cancer cells in vitro

  Karl Y. Hostetler, Steffney Rought, Kathy A. Aldern, Julissa Trahan, James R. Beadle and Jacques Corbeil

  Mol Cancer Ther January 1 2006 5 (1) 156-159; DOI:10.1158/1535-7163.MCT-05-0200

  
  
• Article

  Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

  Holly K. Koblish, Shuyuan Zhao, Carol F. Franks, Robert R. Donatelli, Rose M. Tominovich, Louis V. LaFrance, Kristi A. Leonard, Joan M. Gushue, Daniel J. Parks, Raul R. Calvo, Karen L. Milkiewicz, Juan José Marugán, Pierre Raboisson, Maxwell D. Cummings, Bruce L. Grasberger, Dana L. Johnson, Tianbao Lu, Christopher J. Molloy and Anna C. Maroney

  Mol Cancer Ther January 1 2006 5 (1) 160-169; DOI:10.1158/1535-7163.MCT-05-0199

  
  
• Article

  Sensitization of TRAIL–resistant cells by inhibition of heat shock protein 90 with low-dose geldanamycin

  Yulin Ma, Vijayabaskar Lakshmikanthan, Ronald W. Lewis and M. Vijay Kumar

  Mol Cancer Ther January 1 2006 5 (1) 170-178; DOI:10.1158/1535-7163.MCT-05-0129

  
  
• Article

  Silencing of survivin gene by small interfering RNAs produces supra-additive growth suppression in combination with 17-allylamino-17-demethoxygeldanamycin in human prostate cancer cells

  Francesco Paduano, Raffaella Villa, Marzia Pennati, Marco Folini, Mara Binda, Maria Grazia Daidone and Nadia Zaffaroni

  Mol Cancer Ther January 1 2006 5 (1) 179-186; DOI:10.1158/1535-7163.MCT-05-0132

  
  
• Article

  Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells

  Mounia Beloueche-Babari, L. Elizabeth Jackson, Nada M.S. Al-Saffar, Suzanne A. Eccles, Florence I. Raynaud, Paul Workman, Martin O. Leach and Sabrina M. Ronen

  Mol Cancer Ther January 1 2006 5 (1) 187-196; DOI:10.1158/1535-7163.MCT-03-0220