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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

Cover image

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Tubulin mutations and Taxol/epothilone dependence. Three mutations (βGln292Glu, βVal60Phe and αLeu195Met) in tubulin are present in a highly epothilone B-resistant/dependent A549 cell line. βVal60 has a critical role in the drug dependence phenotype of these cells. The structural model of a tubulin heterodimer is viewed from the inside ( left ) and from the outside ( right ) with β-tubulin at the top. The locations of the mutations are indicated with backbone atoms ( yellow spheres ). A molecule of GTP ( red ) and a molecule of GDP ( red ) bind to α-tubulin and β-tubulin, respectively. Epothilone A ( green ), a potentially important antitumor drug, interacts with β-tubulin. For details, see 987 in this issue.

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Molecular Cancer Therapeutics: 4 (6)
June 2005
Volume 4, Issue 6
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Issue Highlights

  • A highly epothilone B–resistant A549 cell line with mutations in tubulin that confer drug dependence
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Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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