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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Article

Epidermal growth factor receptor (EGFR)–related protein inhibits multiple members of the EGFR family in colon and breast cancer cells

Hu Xu, Yingjie Yu, Dorota Marciniak, Arun K. Rishi, Fazlul H. Sarkar, Omer Kucuk and Adhip P.N. Majumdar
Hu Xu
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Yingjie Yu
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Dorota Marciniak
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Arun K. Rishi
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Fazlul H. Sarkar
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Omer Kucuk
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Adhip P.N. Majumdar
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DOI: 10.1158/1535-7163.MCT-04-0280 Published March 2005
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    Figure 1.

    A, Western blot showing EGFR, HER-2, and HER-4 levels in different colon (HT-29, HCT-116, and Caco2) and breast (MDA-468 and SKBR-3) cell lines, and nontransformed rat small intestinal cell line IEC-6. Each lane contained 25 μg protein. B, effect of increasing concentrations of recombinant ERRP on the growth [determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay] of colon and breast cancer cell lines as well as on cell lines derived from fibroblasts (NIH-3T3 and NIH-3T3/PT-67) and nontransformed rat small intestine (IEC-6). Points, mean of six to seven independent determinations; bars, SE.

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    Figure 2.

    Effects of increasing concentrations of recombinant ERRP, cetuximab (A), or trastuzumab (B) on the growth of colon (HCT-116 and HT-29) and breast (MDA-468 and SKBR-3) cancer cell lines. Cells were exposed to recombinant ERRP, cetuximab, or trastuzumab for 48 h. Points, mean of six to seven determinations; bars, SE. *P < 0.01, compared with the corresponding values of cetuximab- or trastuzumab-treated cells.

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    Figure 3.

    Attenuation of TGF-α (T) and HB-EGF (HB) induced tyrosine phosphorylation of EGFR (p-EGFR; A) and Her-2 (p-Her2;; B) in the presence of recombinant ERRP, cetuximab (Cetux), or tarstuzumab (Trast) in colon (HCT-116 and HT-29) and breast (MDA-468 and SKBR-3) cancer cells. Actin served as the loading control.

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    Figure 4.

    Attenuation of heregulin-α–induced tyrosine phosphorylation of HER-2 (p-HER2) in the presence of recombinant ERRP, cetuximab (Cetux), or tarstuzumab (Trast) in colon (HT-29) and breast (SKBR-3) cancer cells. α-Tubulin served as the loading control.

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    Figure 5.

    Effects of recombinant ERRP, cetuximab, or trastuzumab on apoptosis of colon (HCT-116 and HT-29) and breast (MDA-468 and SKBR-3) cancer cells as well as the mouse fibroblast (NIH-3T3) and nontransformed rat small intestinal IEC-6 cells. Cells were exposed to recombinant ERRP, cetuximab, or trastuzumab for 24 h. Columns, mean of four to five determinations; bars, SE. *P < 0.01, compared with the corresponding controls.

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Molecular Cancer Therapeutics: 4 (3)
March 2005
Volume 4, Issue 3
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Epidermal growth factor receptor (EGFR)–related protein inhibits multiple members of the EGFR family in colon and breast cancer cells
Hu Xu, Yingjie Yu, Dorota Marciniak, Arun K. Rishi, Fazlul H. Sarkar, Omer Kucuk and Adhip P.N. Majumdar
Mol Cancer Ther March 1 2005 (4) (3) 435-442; DOI: 10.1158/1535-7163.MCT-04-0280

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Epidermal growth factor receptor (EGFR)–related protein inhibits multiple members of the EGFR family in colon and breast cancer cells
Hu Xu, Yingjie Yu, Dorota Marciniak, Arun K. Rishi, Fazlul H. Sarkar, Omer Kucuk and Adhip P.N. Majumdar
Mol Cancer Ther March 1 2005 (4) (3) 435-442; DOI: 10.1158/1535-7163.MCT-04-0280
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Molecular Cancer Therapeutics
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