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Molecular Cancer Therapeutics
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Article

Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival

Rubén W. Carón, Adly Yacoub, Min Li, Xiaoyu Zhu, Clint Mitchell, Young Hong, William Hawkins, Takehiko Sasazuki, Senji Shirasawa, Alan P. Kozikowski, Philip A. Dennis, Michael P. Hagan, Steven Grant and Paul Dent
Rubén W. Carón
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Adly Yacoub
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Min Li
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Xiaoyu Zhu
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Clint Mitchell
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Young Hong
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William Hawkins
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Takehiko Sasazuki
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Senji Shirasawa
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Alan P. Kozikowski
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Philip A. Dennis
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Michael P. Hagan
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Steven Grant
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Paul Dent
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DOI:  Published February 2005
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Article Information

Volume 4, Issue 2, pp. 257-270

PubMed 
15713897

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • November 30, 2004
  • September 16, 2004
  • November 17, 2004
  • Published first February 15, 2005.

Copyright & Usage 
American Association for Cancer Research

Author Information

  1. Rubén W. Carón16,
  2. Adly Yacoub1,
  3. Min Li5,
  4. Xiaoyu Zhu1,
  5. Clint Mitchell1,
  6. Young Hong1,
  7. William Hawkins1,
  8. Takehiko Sasazuki3,
  9. Senji Shirasawa3,
  10. Alan P. Kozikowski5,
  11. Philip A. Dennis4,
  12. Michael P. Hagan1,
  13. Steven Grant2 and
  14. Paul Dent1
  1. Departments of 1Radiation Oncology and 2Hematology/Oncology, Virginia Commonwealth University, Richmond, Virginia; 3Department of Pathology, International Medical Center of Japan, Tokyo, Japan; 4National Cancer Institute, Bethesda, Maryland; 5Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois; and 6Instituto de Medicina y Biología Experimental de Cuyo-CONICET, Mendoza, Argentina
  1. Requests for reprints: Paul Dent, Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298-0058. Phone: 804-628-0861; Fax: 804-828-6042. E-mail: pdent{at}hsc.vcu.edu
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Molecular Cancer Therapeutics: 4 (2)
February 2005
Volume 4, Issue 2
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Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival
Rubén W. Carón, Adly Yacoub, Min Li, Xiaoyu Zhu, Clint Mitchell, Young Hong, William Hawkins, Takehiko Sasazuki, Senji Shirasawa, Alan P. Kozikowski, Philip A. Dennis, Michael P. Hagan, Steven Grant and Paul Dent
Mol Cancer Ther February 1 2005 (4) (2) 257-270;

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Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival
Rubén W. Carón, Adly Yacoub, Min Li, Xiaoyu Zhu, Clint Mitchell, Young Hong, William Hawkins, Takehiko Sasazuki, Senji Shirasawa, Alan P. Kozikowski, Philip A. Dennis, Michael P. Hagan, Steven Grant and Paul Dent
Mol Cancer Ther February 1 2005 (4) (2) 257-270;
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Molecular Cancer Therapeutics
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