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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

Cover image

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Src tyrosine kinase inhibition restores sensitivity to paclitaxel-resistant ovarian cancer cells. Pharmacologic inhibition of Src tyrosine kinase was shown to resensitize paclitaxel-resistant mouse and human ovarian cancer cells. To demonstrate specificity, mouse ID8 paclitaxel-resistant ovarian cancer cells were transfected with a Src dominant-negative-EGFP fusion construct (right panels) or EGFP as control (left panels). Cells were then exposed to paclitaxel for 24 hours. Note the fragmented nucleus, indicative of apoptosis, in the Src dominant-negative expressing cell. For details, see Chen et al. in this issue (pp. 217–224).

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Molecular Cancer Therapeutics: 4 (2)
February 2005
Volume 4, Issue 2
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Issue Highlights

  • Src inhibition enhances paclitaxel cytotoxicity in ovarian cancer cells by caspase-9-independent activation of caspase-3
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Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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