Table of Contents

Article

• Article

  Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines

  Beverly E. Barton, Thomas F. Murphy, Ping Shu, Hosea F. Huang, Marcus Meyenhofen and Arnold Barton

  Mol Cancer Ther October 1 2004 3 (10) 1183-1191;

  
  
• Article

  Targeting heterogeneous nuclear ribonucleoparticule A1 and A2 proteins by RNA interference promotes cell death in transformed but not in normal mouse cell lines

  Caroline Patry, Bruno Lemieux, Raymund J. Wellinger and Benoit Chabot

  Mol Cancer Ther October 1 2004 3 (10) 1193-1199;

  
  
• Article

  A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells

  Christopher M. Incles, Christoph M. Schultes, Helena Kempski, Heike Koehler, Lloyd R. Kelland and Stephen Neidle

  Mol Cancer Ther October 1 2004 3 (10) 1201-1206;

  
  
• Article

  Topoisomerase-IIα expression as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel

  Virginie Durbecq, Marianne Paesmans, Fatima Cardoso, Christine Desmedt, Angelo Di Leo, Stephen Chan, Kay Friedrichs, Tamas Pinter, Simon Van Belle, Elizabeth Murray, István Bodrogi, Euan Walpole, Bernard Lesperance, Stefan Korec, John Crown, Peter Simmonds, Thimothy J. Perren, Jean-Yves Leroy, Ghizlane Rouas, Christos Sotiriou, Martine Piccart and Denis Larsimont

  Mol Cancer Ther October 1 2004 3 (10) 1207-1214;

  
  
• Article

  Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O⁶-alkylguanine-DNA alkyltransferase

  Vincent A. Barvaux, Paul Lorigan, Malcolm Ranson, Amanda M. Gillum, R. Stanley McElhinney, T. Brian H. McMurry and Geoffrey P. Margison

  Mol Cancer Ther October 1 2004 3 (10) 1215-1220;

  
  
• Article

  Inhibition of Chk1 by the G₂ DNA damage checkpoint inhibitor isogranulatimide

  Xiuxian Jiang, Baoguang Zhao, Robert Britton, Lynette Y. Lim, Dan Leong, Jasbinder S. Sanghera, Bin-Bing S. Zhou, Edward Piers, Raymond J. Andersen and Michel Roberge

  Mol Cancer Ther October 1 2004 3 (10) 1221-1227;

  
  
• Article

  G₂ cell cycle arrest, down-regulation of cyclin B, and induction of mitotic catastrophe by the flavoprotein inhibitor diphenyleneiodonium

  Robin M. Scaife

  Mol Cancer Ther October 1 2004 3 (10) 1229-1237;

  
  
• Article

  The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice

  Nhu-An Pham, James W. Jacobberger, Aaron D. Schimmer, Pinjiang Cao, Marcella Gronda and David W. Hedley

  Mol Cancer Ther October 1 2004 3 (10) 1239-1248;

  
  
• Article

  Peroxisome proliferator-activated receptor γ and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias

  Marina Konopleva, Elena Elstner, Teresa J. McQueen, Twee Tsao, Andrey Sudarikov, Wei Hu, Wendy D. Schober, Rui-Yu Wang, David Chism, Steven M. Kornblau, Anas Younes, Steven J. Collins, H. Phillip Koeffler and Michael Andreeff

  Mol Cancer Ther October 1 2004 3 (10) 1249-1262;

  
  
• Article

  Bortezomib rapidly suppresses ubiquitin thiolesterification to ubiquitin-conjugating enzymes and inhibits ubiquitination of histones and type I inositol 1,4,5-trisphosphate receptor

  Qun Xu, Michelle Farah, Jack M. Webster and Richard J.H. Wojcikiewicz

  Mol Cancer Ther October 1 2004 3 (10) 1263-1269;

  
  
• Article

  Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model

  Gilda G. Hillman, Yu Wang, Omer Kucuk, Mingxin Che, Daniel R. Doerge, Mark Yudelev, Michael C. Joiner, Brian Marples, Jeffrey D. Forman and Fazlul H. Sarkar

  Mol Cancer Ther October 1 2004 3 (10) 1271-1279;

  
  
• Article

  BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors

  Hidesuke Fukazawa, Kohji Noguchi, Atsuko Masumi, Yuko Murakami and Yoshimasa Uehara

  Mol Cancer Ther October 1 2004 3 (10) 1281-1288;

  
  
• Article

  Inhibition of angiogenesis by growth factor receptor bound protein 2-Src homology 2 domain bound antagonists

  Jesus V. Soriano, Ningfei Liu, Yang Gao, Zhu-Jun Yao, Toshio Ishibashi, Charles Underhill, Terrence R. Burke Jr. and Donald P. Bottaro

  Mol Cancer Ther October 1 2004 3 (10) 1289-1299;

  
  
• Article

  Antiangiogenic activity of paclitaxel is associated with its cytostatic effect, mediated by the initiation but not completion of a mitochondrial apoptotic signaling pathway

  Eddy Pasquier, Manon Carré, Bertrand Pourroy, Laurence Camoin, Ouafa Rebaï, Claudette Briand and Diane Braguer

  Mol Cancer Ther October 1 2004 3 (10) 1301-1310;

  
  
• Article

  Targeting tumor microvessels using doxorubicin encapsulated in a novel thermosensitive liposome

  Qing Chen, Sheng Tong, Mark W. Dewhirst and Fan Yuan

  Mol Cancer Ther October 1 2004 3 (10) 1311-1317;

  
  
• Article

  Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in α-tubulin

  Frank Loganzo, Malathi Hari, Tami Annable, Xingzhi Tan, Daniel B. Morilla, Sylvia Musto, Arie Zask, Joshua Kaplan, Albert A. Minnick Jr., Michael K. May, Semiramis Ayral-Kaloustian, Marianne S. Poruchynsky, Tito Fojo and Lee M. Greenberger

  Mol Cancer Ther October 1 2004 3 (10) 1319-1327;

  
  
• Article

  Novel peptide ligands for integrin α₄β₁ overexpressed in cancer cells

  Masahito Mikawa, Henry Wang, Linlang Guo, Ruiwu Liu, Jan Marik, Yoshikazu Takada, Kit Lam and Derick Lau

  Mol Cancer Ther October 1 2004 3 (10) 1329-1334;