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Molecular Cancer Therapeutics
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Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

BRCA1/MAD2L1 Deficiency Disrupts the Spindle Assembly Checkpoint to Confer Vinorelbine Resistance in Mesothelioma

Sara Busacca, Laura O'Regan, Anita Singh, Annabel J. Sharkey, Alan G. Dawson, Joanna Dzialo, Aimee Parsons, Neelam Kumar, Laurel M. Schunselaar, Naomi Guppy, Apostolos Nakas, Michael Sheaff, Aaron S. Mansfield, Sam M. Janes, Paul Baas, Andrew M. Fry and Dean A. Fennell
Sara Busacca
1Leicester Cancer Research Centre, University of Leicester, Leicester, United Kingdom.
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Laura O'Regan
2Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
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Anita Singh
2Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
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Annabel J. Sharkey
1Leicester Cancer Research Centre, University of Leicester, Leicester, United Kingdom.
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Alan G. Dawson
1Leicester Cancer Research Centre, University of Leicester, Leicester, United Kingdom.
3Department of Thoracic Surgery, Glenfield Hospital, University Hospitals of Leicester, Leicester, United Kingdom.
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Joanna Dzialo
1Leicester Cancer Research Centre, University of Leicester, Leicester, United Kingdom.
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Aimee Parsons
1Leicester Cancer Research Centre, University of Leicester, Leicester, United Kingdom.
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Neelam Kumar
4University College London, UCL Respiratory, London, United Kingdom.
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Laurel M. Schunselaar
5Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
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Naomi Guppy
6University College London Advanced Diagnostics, London, United Kingdom.
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Apostolos Nakas
3Department of Thoracic Surgery, Glenfield Hospital, University Hospitals of Leicester, Leicester, United Kingdom.
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Michael Sheaff
7Department of Histopathology, Barts Health NHS Trust, London, United Kingdom.
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Aaron S. Mansfield
8Department of Oncology, Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota.
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  • ORCID record for Aaron S. Mansfield
Sam M. Janes
4University College London, UCL Respiratory, London, United Kingdom.
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Paul Baas
5Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
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Andrew M. Fry
2Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
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Dean A. Fennell
1Leicester Cancer Research Centre, University of Leicester, Leicester, United Kingdom.
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  • For correspondence: df132@leicester.ac.uk
DOI: 10.1158/1535-7163.MCT-20-0363 Published February 2021
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Article Information

Volume 20, Issue 2, pp. 379-388

DOI 
https://doi.org/10.1158/1535-7163.MCT-20-0363
PubMed 
33158996

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received May 4, 2020
  • Revision received September 2, 2020
  • Accepted October 27, 2020
  • Published first November 6, 2020.

Article Versions

  • Previous version (November 6, 2020 - 08:15).
  • Previous version (January 26, 2021 - 07:11).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Sara Busacca1,
  2. Laura O'Regan2,
  3. Anita Singh2,
  4. Annabel J. Sharkey1,
  5. Alan G. Dawson1,3,
  6. Joanna Dzialo1,
  7. Aimee Parsons1,
  8. Neelam Kumar4,
  9. Laurel M. Schunselaar5,
  10. Naomi Guppy6,
  11. Apostolos Nakas3,
  12. Michael Sheaff7,
  13. Aaron S. Mansfield8,
  14. Sam M. Janes4,
  15. Paul Baas5,
  16. Andrew M. Fry2, and
  17. Dean A. Fennell1,*
  1. 1Leicester Cancer Research Centre, University of Leicester, Leicester, United Kingdom.
  2. 2Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
  3. 3Department of Thoracic Surgery, Glenfield Hospital, University Hospitals of Leicester, Leicester, United Kingdom.
  4. 4University College London, UCL Respiratory, London, United Kingdom.
  5. 5Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
  6. 6University College London Advanced Diagnostics, London, United Kingdom.
  7. 7Department of Histopathology, Barts Health NHS Trust, London, United Kingdom.
  8. 8Department of Oncology, Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota.
  1. ↵*Corresponding Author:
    Dean A. Fennell, University of Leicester & University Hospitals of Leicester, Roberk Kilpatrick Building, Infirmary Square, Leicester LE1 9HN, United Kingdom. Phone: 44-01-1625-25174; E-mail: df132{at}leicester.ac.uk
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Molecular Cancer Therapeutics: 20 (2)
February 2021
Volume 20, Issue 2
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BRCA1/MAD2L1 Deficiency Disrupts the Spindle Assembly Checkpoint to Confer Vinorelbine Resistance in Mesothelioma
Sara Busacca, Laura O'Regan, Anita Singh, Annabel J. Sharkey, Alan G. Dawson, Joanna Dzialo, Aimee Parsons, Neelam Kumar, Laurel M. Schunselaar, Naomi Guppy, Apostolos Nakas, Michael Sheaff, Aaron S. Mansfield, Sam M. Janes, Paul Baas, Andrew M. Fry and Dean A. Fennell
Mol Cancer Ther February 1 2021 (20) (2) 379-388; DOI: 10.1158/1535-7163.MCT-20-0363

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BRCA1/MAD2L1 Deficiency Disrupts the Spindle Assembly Checkpoint to Confer Vinorelbine Resistance in Mesothelioma
Sara Busacca, Laura O'Regan, Anita Singh, Annabel J. Sharkey, Alan G. Dawson, Joanna Dzialo, Aimee Parsons, Neelam Kumar, Laurel M. Schunselaar, Naomi Guppy, Apostolos Nakas, Michael Sheaff, Aaron S. Mansfield, Sam M. Janes, Paul Baas, Andrew M. Fry and Dean A. Fennell
Mol Cancer Ther February 1 2021 (20) (2) 379-388; DOI: 10.1158/1535-7163.MCT-20-0363
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