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Molecular Cancer Therapeutics
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Large Molecule Therapeutics

An Anti–CD22-seco-CBI-Dimer Antibody–Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models

Shang-Fan Yu, Donna W. Lee, Bing Zheng, Geoffrey del Rosario, Douglas Leipold, Helen Booler, Fiona Zhong, Montserrat Carrasco-Triguero, Kyu Hong, Peter Yan, Rebecca K. Rowntree, Melissa M. Schutten, Thomas Pillow, Jack D. Sadowsky, Peter S. Dragovich and Andrew G. Polson
Shang-Fan Yu
Research and Early Development, Genentech Inc., South San Francisco, California.
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Donna W. Lee
Research and Early Development, Genentech Inc., South San Francisco, California.
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  • ORCID record for Donna W. Lee
Bing Zheng
Research and Early Development, Genentech Inc., South San Francisco, California.
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Geoffrey del Rosario
Research and Early Development, Genentech Inc., South San Francisco, California.
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Douglas Leipold
Research and Early Development, Genentech Inc., South San Francisco, California.
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Helen Booler
Research and Early Development, Genentech Inc., South San Francisco, California.
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Fiona Zhong
Research and Early Development, Genentech Inc., South San Francisco, California.
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Montserrat Carrasco-Triguero
Research and Early Development, Genentech Inc., South San Francisco, California.
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  • ORCID record for Montserrat Carrasco-Triguero
Kyu Hong
Research and Early Development, Genentech Inc., South San Francisco, California.
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Peter Yan
Research and Early Development, Genentech Inc., South San Francisco, California.
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Rebecca K. Rowntree
Research and Early Development, Genentech Inc., South San Francisco, California.
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Melissa M. Schutten
Research and Early Development, Genentech Inc., South San Francisco, California.
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Thomas Pillow
Research and Early Development, Genentech Inc., South San Francisco, California.
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Jack D. Sadowsky
Research and Early Development, Genentech Inc., South San Francisco, California.
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Peter S. Dragovich
Research and Early Development, Genentech Inc., South San Francisco, California.
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Andrew G. Polson
Research and Early Development, Genentech Inc., South San Francisco, California.
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  • For correspondence: polson@gene.com
DOI: 10.1158/1535-7163.MCT-20-0046 Published February 2021
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ARTICLE USAGE: December 2020 to March 2021

AbstractFull-text HTMLPDF
Total84538114

Cited By

Article Information

Volume 20, Issue 2, pp. 340-346

DOI 
https://doi.org/10.1158/1535-7163.MCT-20-0046
PubMed 
33273056

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received January 21, 2020
  • Revision received July 7, 2020
  • Accepted November 9, 2020
  • Published first December 3, 2020.

Article Versions

  • Previous version (December 3, 2020 - 07:09).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Shang-Fan Yu#,
  2. Donna W. Lee#,
  3. Bing Zheng#,
  4. Geoffrey del Rosario,
  5. Douglas Leipold,
  6. Helen Booler,
  7. Fiona Zhong,
  8. Montserrat Carrasco-Triguero,
  9. Kyu Hong,
  10. Peter Yan,
  11. Rebecca K. Rowntree,
  12. Melissa M. Schutten,
  13. Thomas Pillow,
  14. Jack D. Sadowsky,
  15. Peter S. Dragovich, and
  16. Andrew G. Polson*
  1. Research and Early Development, Genentech Inc., South San Francisco, California.
  1. ↵*Corresponding Author:
    Andrew G. Polson, Genentech Research and Early Development, 1 DNA Way, South San Francisco, CA 94080. Phone: 650-225-5134; Fax: 650-225-6240; E-mail: polson{at}gene.com
  1. ↵#S.-F. Yu, D.W. Lee, and B. Zheng contributed equally to this article.

  • Current address for K. Hong: Immune-Onc Therapeutics, Inc., Palo Alto, California; and current address for P. Yan: University of California San Francisco, San Francisco, California.

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Molecular Cancer Therapeutics: 20 (2)
February 2021
Volume 20, Issue 2
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An Anti–CD22-seco-CBI-Dimer Antibody–Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models
Shang-Fan Yu, Donna W. Lee, Bing Zheng, Geoffrey del Rosario, Douglas Leipold, Helen Booler, Fiona Zhong, Montserrat Carrasco-Triguero, Kyu Hong, Peter Yan, Rebecca K. Rowntree, Melissa M. Schutten, Thomas Pillow, Jack D. Sadowsky, Peter S. Dragovich and Andrew G. Polson
Mol Cancer Ther February 1 2021 (20) (2) 340-346; DOI: 10.1158/1535-7163.MCT-20-0046

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An Anti–CD22-seco-CBI-Dimer Antibody–Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models
Shang-Fan Yu, Donna W. Lee, Bing Zheng, Geoffrey del Rosario, Douglas Leipold, Helen Booler, Fiona Zhong, Montserrat Carrasco-Triguero, Kyu Hong, Peter Yan, Rebecca K. Rowntree, Melissa M. Schutten, Thomas Pillow, Jack D. Sadowsky, Peter S. Dragovich and Andrew G. Polson
Mol Cancer Ther February 1 2021 (20) (2) 340-346; DOI: 10.1158/1535-7163.MCT-20-0046
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Molecular Cancer Therapeutics
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