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Molecular Cancer Therapeutics
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Small Molecule Therapeutics

Inhibition of Intermedin (Adrenomedullin 2) Suppresses the Growth of Glioblastoma and Increases the Antitumor Activity of Temozolomide

Luping Huang, Denian Wang, Zhongxue Feng, Huan Zhao, Fei Xiao, Yong'gang Wei, Heng Zhang, Hongyu Li, Lingmiao Kong, Min Li, Fei Liu, Haili Zhang and Wei Zhang
Luping Huang
1Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Sichuan, China.
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Denian Wang
2Department of Respiratory and Critical Care Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
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Zhongxue Feng
1Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Sichuan, China.
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Huan Zhao
1Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Sichuan, China.
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Fei Xiao
3Department of Intensive Care Unit of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Sichuan, China.
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Yong'gang Wei
4Department of Liver Surgery, West China Hospital, Sichuan University, Sichuan, China.
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Heng Zhang
5Department of Neurosurgery, West China Hospital, Sichuan University, Sichuan, China.
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Hongyu Li
6Liver Transplantation Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
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Lingmiao Kong
1Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Sichuan, China.
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Min Li
1Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Sichuan, China.
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Fei Liu
4Department of Liver Surgery, West China Hospital, Sichuan University, Sichuan, China.
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Haili Zhang
4Department of Liver Surgery, West China Hospital, Sichuan University, Sichuan, China.
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Wei Zhang
1Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Sichuan, China.
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  • For correspondence: zhangwei197610@163.com
DOI: 10.1158/1535-7163.MCT-20-0619 Published February 2021
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ARTICLE USAGE: December 2020 to February 2021

AbstractFull-text HTMLPDF
Total361163183

Cited By

Article Information

Volume 20, Issue 2, pp. 284-295

DOI 
https://doi.org/10.1158/1535-7163.MCT-20-0619
PubMed 
33298587

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received July 20, 2020
  • Revision received September 24, 2020
  • Accepted November 18, 2020
  • Published first December 9, 2020.

Article Versions

  • Previous version (December 9, 2020 - 07:06).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Luping Huang1,#,
  2. Denian Wang2,#,
  3. Zhongxue Feng1,#,
  4. Huan Zhao1,#,
  5. Fei Xiao3,#,
  6. Yong'gang Wei4,#,
  7. Heng Zhang5,
  8. Hongyu Li6,#,
  9. Lingmiao Kong1,
  10. Min Li1,
  11. Fei Liu4,
  12. Haili Zhang4, and
  13. Wei Zhang1,*
  1. 1Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Sichuan, China.
  2. 2Department of Respiratory and Critical Care Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
  3. 3Department of Intensive Care Unit of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Sichuan, China.
  4. 4Department of Liver Surgery, West China Hospital, Sichuan University, Sichuan, China.
  5. 5Department of Neurosurgery, West China Hospital, Sichuan University, Sichuan, China.
  6. 6Liver Transplantation Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  1. ↵*Corresponding Author:
    Wei Zhang, Department of Critical Care Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, No. 1, Ke Yuan 4th Road, Chengdu 610041, China. Phone: 86-28-85164092; Fax: 86-28-85164092; E-mail: zhangwei197610{at}163.com
  1. ↵#L. Huang, D. Wang, Z. Feng, H. Zhao, F. Xiao, Y. Wei, and H. Li contributed equally to this article.

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Molecular Cancer Therapeutics: 20 (2)
February 2021
Volume 20, Issue 2
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Inhibition of Intermedin (Adrenomedullin 2) Suppresses the Growth of Glioblastoma and Increases the Antitumor Activity of Temozolomide
Luping Huang, Denian Wang, Zhongxue Feng, Huan Zhao, Fei Xiao, Yong'gang Wei, Heng Zhang, Hongyu Li, Lingmiao Kong, Min Li, Fei Liu, Haili Zhang and Wei Zhang
Mol Cancer Ther February 1 2021 (20) (2) 284-295; DOI: 10.1158/1535-7163.MCT-20-0619

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Inhibition of Intermedin (Adrenomedullin 2) Suppresses the Growth of Glioblastoma and Increases the Antitumor Activity of Temozolomide
Luping Huang, Denian Wang, Zhongxue Feng, Huan Zhao, Fei Xiao, Yong'gang Wei, Heng Zhang, Hongyu Li, Lingmiao Kong, Min Li, Fei Liu, Haili Zhang and Wei Zhang
Mol Cancer Ther February 1 2021 (20) (2) 284-295; DOI: 10.1158/1535-7163.MCT-20-0619
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Molecular Cancer Therapeutics
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