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Small Molecule Therapeutics

Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination–Proficient Pancreatic Cancer

Leslie A. Parsels, Carl G. Engelke, Joshua Parsels, Sheryl A. Flanagan, Qiang Zhang, Daria Tanska, Daniel R. Wahl, Christine E. Canman, Theodore S. Lawrence and Meredith A. Morgan
Leslie A. Parsels
1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan.
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Carl G. Engelke
1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan.
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Joshua Parsels
1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan.
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Sheryl A. Flanagan
1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan.
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Qiang Zhang
1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan.
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Daria Tanska
1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan.
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Daniel R. Wahl
1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan.
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Christine E. Canman
2Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.
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Theodore S. Lawrence
1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan.
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  • ORCID record for Theodore S. Lawrence
Meredith A. Morgan
1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan.
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  • For correspondence: mmccrack@med.umich.edu
DOI: 10.1158/1535-7163.MCT-20-0365 Published February 2021
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Cited By

Article Information

Volume 20, Issue 2, pp. 263-273

DOI 
https://doi.org/10.1158/1535-7163.MCT-20-0365
PubMed 
33268569

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received May 4, 2020
  • Revision received July 6, 2020
  • Accepted November 9, 2020
  • Published first December 2, 2020.

Article Versions

  • Previous version (December 2, 2020 - 07:03).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Leslie A. Parsels1,#,
  2. Carl G. Engelke1,#,
  3. Joshua Parsels1,
  4. Sheryl A. Flanagan1,
  5. Qiang Zhang1,
  6. Daria Tanska1,
  7. Daniel R. Wahl1,
  8. Christine E. Canman2,
  9. Theodore S. Lawrence1, and
  10. Meredith A. Morgan1,*
  1. 1Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan.
  2. 2Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.
  1. ↵*Corresponding Author:
    Meredith A. Morgan, University of Michigan, 1301 Catherine St., 4326B Med Sci I, Ann Arbor, MI 48109. Phone: 734-647-5928; Fax: 734-763-1581; E-mail: mmccrack{at}med.umich.edu
  1. ↵#L.A. Parsels and C.G. Engelke contributed equally to this article.

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Molecular Cancer Therapeutics: 20 (2)
February 2021
Volume 20, Issue 2
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Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination–Proficient Pancreatic Cancer
Leslie A. Parsels, Carl G. Engelke, Joshua Parsels, Sheryl A. Flanagan, Qiang Zhang, Daria Tanska, Daniel R. Wahl, Christine E. Canman, Theodore S. Lawrence and Meredith A. Morgan
Mol Cancer Ther February 1 2021 (20) (2) 263-273; DOI: 10.1158/1535-7163.MCT-20-0365

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Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination–Proficient Pancreatic Cancer
Leslie A. Parsels, Carl G. Engelke, Joshua Parsels, Sheryl A. Flanagan, Qiang Zhang, Daria Tanska, Daniel R. Wahl, Christine E. Canman, Theodore S. Lawrence and Meredith A. Morgan
Mol Cancer Ther February 1 2021 (20) (2) 263-273; DOI: 10.1158/1535-7163.MCT-20-0365
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