Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer

Yuchen Zhang; Michael B. Ware; Mohammad Y. Zaidi; Amanda N. Ruggieri; Brian M. Olson; Hannah Komar; Matthew R. Farren; Ganji Purnachandra Nagaraju; Chao Zhang; Zhengjia Chen; Juan M. Sarmiento; Rafi Ahmed; Shishir K. Maithel; Bassel F. El-Rayes; Gregory B. Lesinski

doi:10.1158/1535-7163.MCT-19-0911

Cancer Biology and Translational Studies

Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer

Yuchen Zhang, Michael B. Ware, Mohammad Y. Zaidi, Amanda N. Ruggieri, Brian M. Olson, Hannah Komar, Matthew R. Farren, Ganji Purnachandra Nagaraju, Chao Zhang, Zhengjia Chen, Juan M. Sarmiento, Rafi Ahmed, Shishir K. Maithel, Bassel F. El-Rayes and Gregory B. Lesinski

Yuchen Zhang

1Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.

2Department of Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China.

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Michael B. Ware

1Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.

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Mohammad Y. Zaidi

3Department of Surgery, Winship Cancer Institute of Emory University, Atlanta, Georgia.

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Amanda N. Ruggieri

1Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.

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Brian M. Olson

1Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.

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Hannah Komar

1Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.

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Matthew R. Farren

1Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.

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Ganji Purnachandra Nagaraju

1Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.

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Chao Zhang

4Department of Biostatistics, Winship Cancer Institute of Emory University, Atlanta, Georgia.

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Zhengjia Chen

5Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, Illinois.

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Juan M. Sarmiento

3Department of Surgery, Winship Cancer Institute of Emory University, Atlanta, Georgia.

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Rafi Ahmed

6Emory Vaccine Center, Atlanta, Georgia.

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Shishir K. Maithel

3Department of Surgery, Winship Cancer Institute of Emory University, Atlanta, Georgia.

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Bassel F. El-Rayes

1Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.

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ORCID record for Bassel F. El-Rayes
For correspondence: gregory.b.lesinski@emory.edu bassel.el-rayes@emoryhealthcare.org

Gregory B. Lesinski

1Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.

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For correspondence: gregory.b.lesinski@emory.edu bassel.el-rayes@emoryhealthcare.org

DOI: 10.1158/1535-7163.MCT-19-0911 Published January 2021

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Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer

Mol Cancer Ther January 1 2021 (20) (1) 150-160; DOI: 10.1158/1535-7163.MCT-19-0911

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Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer

Mol Cancer Ther January 1 2021 (20) (1) 150-160; DOI: 10.1158/1535-7163.MCT-19-0911

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