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Molecular Cancer Therapeutics
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Large Molecule Therapeutics

Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies

Julie Preillon, Julia Cuende, Virginie Rabolli, Lucile Garnero, Marjorie Mercier, Noémie Wald, Angela Pappalardo, Sofie Denies, Diane Jamart, Anne-Catherine Michaux, Romain Pirson, Vincent Pitard, Martine Bagot, Shruthi Prasad, Erica Houthuys, Margreet Brouwer, Reece Marillier, Florence Lambolez, Joäo R. Marchante, Florence Nyawouame, Mathew J. Carter, Véronique Baron-Bodo, Anne Marie-Cardine, Mark Cragg, Julie Déchanet-Merville, Gregory Driessens and Catherine Hoofd
Julie Preillon
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Julia Cuende
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Virginie Rabolli
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Lucile Garnero
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Marjorie Mercier
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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  • ORCID record for Marjorie Mercier
Noémie Wald
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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  • ORCID record for Noémie Wald
Angela Pappalardo
2ImmunoConcEpT, UMR 5164, Bordeaux University, CNRS, Bordeaux, France.
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Sofie Denies
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Diane Jamart
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Anne-Catherine Michaux
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Romain Pirson
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Vincent Pitard
2ImmunoConcEpT, UMR 5164, Bordeaux University, CNRS, Bordeaux, France.
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Martine Bagot
3INSERM U976, Université de Paris, Hôpital Saint Louis, Paris, France.
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Shruthi Prasad
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Erica Houthuys
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Margreet Brouwer
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Reece Marillier
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Florence Lambolez
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Joäo R. Marchante
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Florence Nyawouame
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Mathew J. Carter
4Antibody & Vaccine Group, Centre for Cancer Immunology, Cancer Sciences Unit, Southampton University Faculty of Medicine, Southampton, United Kingdom.
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Véronique Baron-Bodo
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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Anne Marie-Cardine
3INSERM U976, Université de Paris, Hôpital Saint Louis, Paris, France.
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Mark Cragg
4Antibody & Vaccine Group, Centre for Cancer Immunology, Cancer Sciences Unit, Southampton University Faculty of Medicine, Southampton, United Kingdom.
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Julie Déchanet-Merville
2ImmunoConcEpT, UMR 5164, Bordeaux University, CNRS, Bordeaux, France.
5Team labeled LIGUE 2017.
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Gregory Driessens
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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  • For correspondence: gregory.driessens@iteostherapeutics.com
Catherine Hoofd
1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
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DOI: 10.1158/1535-7163.MCT-20-0464 Published January 2021
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Article Information

Volume 20, Issue 1, pp. 121-131

DOI 
https://doi.org/10.1158/1535-7163.MCT-20-0464
PubMed 
33277440

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received June 5, 2020
  • Revision received August 24, 2020
  • Accepted November 3, 2020
  • Published first December 4, 2020.

Article Versions

  • Previous version (December 4, 2020 - 07:26).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Julie Preillon1,#,
  2. Julia Cuende1,#,
  3. Virginie Rabolli1,#,
  4. Lucile Garnero1,
  5. Marjorie Mercier1,
  6. Noémie Wald1,
  7. Angela Pappalardo2,
  8. Sofie Denies1,
  9. Diane Jamart1,
  10. Anne-Catherine Michaux1,
  11. Romain Pirson1,
  12. Vincent Pitard2,
  13. Martine Bagot3,
  14. Shruthi Prasad1,
  15. Erica Houthuys1,
  16. Margreet Brouwer1,
  17. Reece Marillier1,
  18. Florence Lambolez1,
  19. Joäo R. Marchante1,
  20. Florence Nyawouame1,
  21. Mathew J. Carter4,
  22. Véronique Baron-Bodo1,
  23. Anne Marie-Cardine3,
  24. Mark Cragg4,
  25. Julie Déchanet-Merville2,5,
  26. Gregory Driessens1,#,*, and
  27. Catherine Hoofd1,#
  1. 1iTeos Therapeutics, Gosselies, Belgium and Cambridge, Massachusetts.
  2. 2ImmunoConcEpT, UMR 5164, Bordeaux University, CNRS, Bordeaux, France.
  3. 3INSERM U976, Université de Paris, Hôpital Saint Louis, Paris, France.
  4. 4Antibody & Vaccine Group, Centre for Cancer Immunology, Cancer Sciences Unit, Southampton University Faculty of Medicine, Southampton, United Kingdom.
  5. 5Team labeled LIGUE 2017.
  1. ↵*Corresponding Author:
    Gregory Driessens, Rue des Frères Wright 29, Gosselies 6041, Belgium. Phone: 327-191-9962; E-mail: gregory.driessens{at}iteostherapeutics.com
  1. ↵#J. Preillon, J. Cuende, V. Rabolli, G. Driessens, and C. Hoofd contributed equally to this article.

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Molecular Cancer Therapeutics: 20 (1)
January 2021
Volume 20, Issue 1
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Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies
Julie Preillon, Julia Cuende, Virginie Rabolli, Lucile Garnero, Marjorie Mercier, Noémie Wald, Angela Pappalardo, Sofie Denies, Diane Jamart, Anne-Catherine Michaux, Romain Pirson, Vincent Pitard, Martine Bagot, Shruthi Prasad, Erica Houthuys, Margreet Brouwer, Reece Marillier, Florence Lambolez, Joäo R. Marchante, Florence Nyawouame, Mathew J. Carter, Véronique Baron-Bodo, Anne Marie-Cardine, Mark Cragg, Julie Déchanet-Merville, Gregory Driessens and Catherine Hoofd
Mol Cancer Ther January 1 2021 (20) (1) 121-131; DOI: 10.1158/1535-7163.MCT-20-0464

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Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies
Julie Preillon, Julia Cuende, Virginie Rabolli, Lucile Garnero, Marjorie Mercier, Noémie Wald, Angela Pappalardo, Sofie Denies, Diane Jamart, Anne-Catherine Michaux, Romain Pirson, Vincent Pitard, Martine Bagot, Shruthi Prasad, Erica Houthuys, Margreet Brouwer, Reece Marillier, Florence Lambolez, Joäo R. Marchante, Florence Nyawouame, Mathew J. Carter, Véronique Baron-Bodo, Anne Marie-Cardine, Mark Cragg, Julie Déchanet-Merville, Gregory Driessens and Catherine Hoofd
Mol Cancer Ther January 1 2021 (20) (1) 121-131; DOI: 10.1158/1535-7163.MCT-20-0464
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Molecular Cancer Therapeutics
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