Molecular Cancer Therapeutics: 20 (1)

Highlights

Highlights

Selected Articles from This Issue

Mol Cancer Ther January 1 2021 20 (1) 1-1;

Review

Review

Targeting PIM Kinases to Overcome Therapeutic Resistance in Cancer

Rachel K. Toth and Noel A. Warfel

Mol Cancer Ther January 1 2021 20 (1) 3-10; DOI:10.1158/1535-7163.MCT-20-0535

Small Molecule Therapeutics

Small Molecule Therapeutics

Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer

Balkees Abderrahman, Philipp Y. Maximov, Ramona F. Curpan, Sean W. Fanning, Jay S. Hanspal, Ping Fan, Charles E. Foulds, Yue Chen, Anna Malovannaya, Antrix Jain, Rui Xiong, Geoffrey L. Greene, Debra A. Tonetti, Gregory R.J. Thatcher and V. Craig Jordan

Mol Cancer Ther January 1 2021 20 (1) 11-25; DOI:10.1158/1535-7163.MCT-20-0563
Small Molecule Therapeutics | AuthorChoice

Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A

Peggy A. Thompson, Boreth Eam, Nathan P. Young, Sarah Fish, Joan Chen, Maria Barrera, Haleigh Howard, Eric Sung, Ana Parra, Jocelyn Staunton, Gary G. Chiang, Adina Gerson-Gurwitz, Christopher J. Wegerski, Andres Nevarez, Jeff Clarine, Samuel Sperry, Alan Xiang, Christian Nilewski, Garrick K. Packard, Theodore Michels, Chinh Tran, Paul A. Sprengeler, Justin T. Ernst, Siegfried H. Reich and Kevin R. Webster

Mol Cancer Ther January 1 2021 20 (1) 26-36; DOI:10.1158/1535-7163.MCT-19-0973
Small Molecule Therapeutics

TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity

Jamilah Abusarah, Yun Cui, Nehme El-Hachem, Abed El-Hakim El-Kadiry, Ian Hammond-Martel, Hugo Wurtele, Annie Beaudry, Noël J.-M. Raynal, Francis Robert, Jerry Pelletier, Maja Jankovic, Francois Mercier, Samaneh Kamyabiazar, Borhane Annabi and Moutih Rafei

Mol Cancer Ther January 1 2021 20 (1) 37-49; DOI:10.1158/1535-7163.MCT-20-0333
Small Molecule Therapeutics

Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth

Shauni Lien Geeraerts, Kim Rosalie Kampen, Gianmarco Rinaldi, Purvi Gupta, Mélanie Planque, Nikolaos Louros, Elien Heylen, Kaat De Cremer, Katrijn De Brucker, Stijn Vereecke, Benno Verbelen, Pieter Vermeersch, Joost Schymkowitz, Frederic Rousseau, David Cassiman, Sarah-Maria Fendt, Arnout Voet, Bruno P.A. Cammue, Karin Thevissen and Kim De Keersmaecker

Mol Cancer Ther January 1 2021 20 (1) 50-63; DOI:10.1158/1535-7163.MCT-20-0480
Small Molecule Therapeutics | AuthorChoice

Reprogramming of Nucleotide Metabolism Mediates Synergy between Epigenetic Therapy and MAP Kinase Inhibition

Tatiana Shorstova, Jie Su, Tiejun Zhao, Michael Dahabieh, Matthew Leibovitch, Mariana De Sa Tavares Russo, Daina Avizonis, Shivshankari Rajkumar, Ian R. Watson, Sonia V. del Rincón, Wilson H. Miller Jr, William D. Foulkes and Michael Witcher

Mol Cancer Ther January 1 2021 20 (1) 64-75; DOI:10.1158/1535-7163.MCT-20-0259
Small Molecule Therapeutics

Disruption of SND1–MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells In Vitro and In Vivo

Peng Li, Yunjiao He, Teng Chen, Kit-Ying Choy, Tsun Sing Chow, Iris L.K. Wong, Xinqing Yang, Wenqin Sun, Xiaochun Su, Tak-Hang Chan and Larry M.C. Chow

Mol Cancer Ther January 1 2021 20 (1) 76-84; DOI:10.1158/1535-7163.MCT-20-0130
Small Molecule Therapeutics

Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance

Zhiqing Huang, Eiji Kondoh, Zachary R. Visco, Tsukasa Baba, Noriomi Matsumura, Emma Dolan, Regina S. Whitaker, Ikuo Konishi, Shingo Fujii, Andrew Berchuck and Susan K. Murphy

Mol Cancer Ther January 1 2021 20 (1) 85-95; DOI:10.1158/1535-7163.MCT-20-0119

Large Molecule Therapeutics

Large Molecule Therapeutics | AuthorChoice

Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist

Juan Manuel García-Martínez, Shirley Wang, Cordula Weishaeupl, Andreas Wernitznig, Paolo Chetta, Catarina Pinto, Jason Ho, Darrin Dutcher, Philip N. Gorman, Rachel Kroe-Barrett, Joerg Rinnenthal, Craig Giragossian, Maria Antonietta Impagnatiello, Iñigo Tirapu, Frank Hilberg, Norbert Kraut, Mark Pearson and Klaus Peter Kuenkele

Mol Cancer Ther January 1 2021 20 (1) 96-108; DOI:10.1158/1535-7163.MCT-20-0253
Large Molecule Therapeutics | AuthorChoice

TriTACs, a Novel Class of T-Cell–Engaging Protein Constructs Designed for the Treatment of Solid Tumors

Richard J. Austin, Bryan D. Lemon, Wade H. Aaron, Manasi Barath, Patricia A. Culp, Robert B. DuBridge, Luke B. Evnin, Adrie Jones, Anand Panchal, Purbasa Patnaik, Vanitha Ramakrishnan, Sony S. Rocha, Pui Seto, Kenneth Sexton, Kathryn L. Strobel, Russell Wall, Stephen Yu, Timothy Z. Yu, Che-Leung Law, Patrick A. Baeuerle and Holger Wesche

Mol Cancer Ther January 1 2021 20 (1) 109-120; DOI:10.1158/1535-7163.MCT-20-0061
Large Molecule Therapeutics

Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies

Julie Preillon, Julia Cuende, Virginie Rabolli, Lucile Garnero, Marjorie Mercier, Noémie Wald, Angela Pappalardo, Sofie Denies, Diane Jamart, Anne-Catherine Michaux, Romain Pirson, Vincent Pitard, Martine Bagot, Shruthi Prasad, Erica Houthuys, Margreet Brouwer, Reece Marillier, Florence Lambolez, Joäo R. Marchante, Florence Nyawouame, Mathew J. Carter, Véronique Baron-Bodo, Anne Marie-Cardine, Mark Cragg, Julie Déchanet-Merville, Gregory Driessens and Catherine Hoofd

Mol Cancer Ther January 1 2021 20 (1) 121-131; DOI:10.1158/1535-7163.MCT-20-0464

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers | AuthorChoice

Circulating Tumor Cells and Biomarker Modulation with Olaratumab Monotherapy Followed by Olaratumab plus Doxorubicin: Phase Ib Study in Patients with Soft-Tissue Sarcoma

Javier Martín-Broto, Antonio López Pousa, Andrew S. Brohl, Brian A. Van Tine, Benjamin Powers, Silvia Stacchiotti, Jean-Yves Blay, James S. Hu, Gerard J. Oakley III, Hong Wang, Anna M. Szpurka, Donna E. Levy, Gary Mo, Matteo Ceccarelli and Robin L. Jones

Mol Cancer Ther January 1 2021 20 (1) 132-141; DOI:10.1158/1535-7163.MCT-20-0441
Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

HLA Polymorphisms Are Associated with Treatment-Free Remission Following Discontinuation of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia

Hiroshi Ureshino, Takero Shindo, Hidenori Tanaka, Hiroh Saji and Shinya Kimura

Mol Cancer Ther January 1 2021 20 (1) 142-149; DOI:10.1158/1535-7163.MCT-20-0336

Cancer Biology and Translational Studies

Cancer Biology and Translational Studies

Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer

Yuchen Zhang, Michael B. Ware, Mohammad Y. Zaidi, Amanda N. Ruggieri, Brian M. Olson, Hannah Komar, Matthew R. Farren, Ganji Purnachandra Nagaraju, Chao Zhang, Zhengjia Chen, Juan M. Sarmiento, Rafi Ahmed, Shishir K. Maithel, Bassel F. El-Rayes and Gregory B. Lesinski

Mol Cancer Ther January 1 2021 20 (1) 150-160; DOI:10.1158/1535-7163.MCT-19-0911
Cancer Biology and Translational Studies

PLK1 and NOTCH Positively Correlate in Melanoma and Their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways

Shengqin Su, Gagan Chhabra, Mary A. Ndiaye, Chandra K. Singh, Ting Ye, Wei Huang, Colin N. Dewey, Vijayasaradhi Setaluri and Nihal Ahmad

Mol Cancer Ther January 1 2021 20 (1) 161-172; DOI:10.1158/1535-7163.MCT-20-0654
Cancer Biology and Translational Studies

Recombinant Orthopoxvirus Primes Colon Cancer for Checkpoint Inhibitor and Cross-Primes T Cells for Antitumor and Antiviral Immunity

Sang-In Kim, Anthony K. Park, Shyambabu Chaurasiya, Seonah Kang, Jianming Lu, Annie Yang, Venkatesh Sivanandam, Zhifang Zhang, Yanghee Woo, Saul J. Priceman, Yuman Fong and Susanne G. Warner

Mol Cancer Ther January 1 2021 20 (1) 173-182; DOI:10.1158/1535-7163.MCT-20-0405
Cancer Biology and Translational Studies

The Landscape of Glycogen Synthase Kinase-3 Beta Genomic Alterations in Cancer

Brittany A. Borden, Yasmine Baca, Joanne Xiu, Fabio Tavora, Ira Winer, Benjamin A. Weinberg, Ari M. Vanderwalde, Sourat Darabi, W. Michael Korn, Andrew P. Mazar, Francis J. Giles, Lorin Crawford, Howard Safran, Wafik S. El-Deiry and Benedito A. Carneiro

Mol Cancer Ther January 1 2021 20 (1) 183-190; DOI:10.1158/1535-7163.MCT-20-0497
Cancer Biology and Translational Studies

IOX1 Suppresses Wnt Target Gene Transcription and Colorectal Cancer Tumorigenesis through Inhibition of KDM3 Histone Demethylases

Rosalie G. Hoyle, Huiqun Wang, Yana Cen, Yan Zhang and Jiong Li

Mol Cancer Ther January 1 2021 20 (1) 191-202; DOI:10.1158/1535-7163.MCT-20-0328

Models and Technologies

Models and Technologies | AuthorChoice

Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody–Drug Conjugates to Increase In Vivo Efficacy

Jose F. Ponte, Leanne Lanieri, Eshita Khera, Rassol Laleau, Olga Ab, Christopher Espelin, Neeraj Kohli, Bahar Matin, Yulius Setiady, Michael L. Miller, Thomas A. Keating, Ravi Chari, Jan Pinkas, Richard Gregory and Greg M. Thurber

Mol Cancer Ther January 1 2021 20 (1) 203-212; DOI:10.1158/1535-7163.MCT-20-0451

Acknowledgment to Reviewers

Acknowledgment to Reviewers | Free Article

Acknowledgment to Reviewers

Mol Cancer Ther January 1 2021 20 (1) 213-216; DOI:10.1158/1535-7163.MCT-20-1-reviewers

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Table of Contents

Highlights

Review

Small Molecule Therapeutics

Large Molecule Therapeutics

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

Cancer Biology and Translational Studies

Models and Technologies

Acknowledgment to Reviewers

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