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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Highlights

  • Highlights
    Selected Articles from This Issue
    Mol Cancer Ther January 1 2021 20 (1) 1-1;

Review

  • Review
    Targeting PIM Kinases to Overcome Therapeutic Resistance in Cancer
    Rachel K. Toth and Noel A. Warfel
    Mol Cancer Ther January 1 2021 20 (1) 3-10; DOI:10.1158/1535-7163.MCT-20-0535

Small Molecule Therapeutics

  • Small Molecule Therapeutics
    Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer
    Balkees Abderrahman, Philipp Y. Maximov, Ramona F. Curpan, Sean W. Fanning, Jay S. Hanspal, Ping Fan, Charles E. Foulds, Yue Chen, Anna Malovannaya, Antrix Jain, Rui Xiong, Geoffrey L. Greene, Debra A. Tonetti, Gregory R.J. Thatcher and V. Craig Jordan
    Mol Cancer Ther January 1 2021 20 (1) 11-25; DOI:10.1158/1535-7163.MCT-20-0563

  • Small Molecule Therapeutics | AuthorChoice
    Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A
    Peggy A. Thompson, Boreth Eam, Nathan P. Young, Sarah Fish, Joan Chen, Maria Barrera, Haleigh Howard, Eric Sung, Ana Parra, Jocelyn Staunton, Gary G. Chiang, Adina Gerson-Gurwitz, Christopher J. Wegerski, Andres Nevarez, Jeff Clarine, Samuel Sperry, Alan Xiang, Christian Nilewski, Garrick K. Packard, Theodore Michels, Chinh Tran, Paul A. Sprengeler, Justin T. Ernst, Siegfried H. Reich and Kevin R. Webster
    Mol Cancer Ther January 1 2021 20 (1) 26-36; DOI:10.1158/1535-7163.MCT-19-0973

  • Small Molecule Therapeutics
    TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity
    Jamilah Abusarah, Yun Cui, Nehme El-Hachem, Abed El-Hakim El-Kadiry, Ian Hammond-Martel, Hugo Wurtele, Annie Beaudry, Noël J.-M. Raynal, Francis Robert, Jerry Pelletier, Maja Jankovic, Francois Mercier, Samaneh Kamyabiazar, Borhane Annabi and Moutih Rafei
    Mol Cancer Ther January 1 2021 20 (1) 37-49; DOI:10.1158/1535-7163.MCT-20-0333

  • Small Molecule Therapeutics
    Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth
    Shauni Lien Geeraerts, Kim Rosalie Kampen, Gianmarco Rinaldi, Purvi Gupta, Mélanie Planque, Nikolaos Louros, Elien Heylen, Kaat De Cremer, Katrijn De Brucker, Stijn Vereecke, Benno Verbelen, Pieter Vermeersch, Joost Schymkowitz, Frederic Rousseau, David Cassiman, Sarah-Maria Fendt, Arnout Voet, Bruno P.A. Cammue, Karin Thevissen and Kim De Keersmaecker
    Mol Cancer Ther January 1 2021 20 (1) 50-63; DOI:10.1158/1535-7163.MCT-20-0480

  • Small Molecule Therapeutics | AuthorChoice
    Reprogramming of Nucleotide Metabolism Mediates Synergy between Epigenetic Therapy and MAP Kinase Inhibition
    Tatiana Shorstova, Jie Su, Tiejun Zhao, Michael Dahabieh, Matthew Leibovitch, Mariana De Sa Tavares Russo, Daina Avizonis, Shivshankari Rajkumar, Ian R. Watson, Sonia V. del Rincón, Wilson H. Miller Jr, William D. Foulkes and Michael Witcher
    Mol Cancer Ther January 1 2021 20 (1) 64-75; DOI:10.1158/1535-7163.MCT-20-0259

  • Small Molecule Therapeutics
    Disruption of SND1–MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells In Vitro and In Vivo
    Peng Li, Yunjiao He, Teng Chen, Kit-Ying Choy, Tsun Sing Chow, Iris L.K. Wong, Xinqing Yang, Wenqin Sun, Xiaochun Su, Tak-Hang Chan and Larry M.C. Chow
    Mol Cancer Ther January 1 2021 20 (1) 76-84; DOI:10.1158/1535-7163.MCT-20-0130

  • Small Molecule Therapeutics
    Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance
    Zhiqing Huang, Eiji Kondoh, Zachary R. Visco, Tsukasa Baba, Noriomi Matsumura, Emma Dolan, Regina S. Whitaker, Ikuo Konishi, Shingo Fujii, Andrew Berchuck and Susan K. Murphy
    Mol Cancer Ther January 1 2021 20 (1) 85-95; DOI:10.1158/1535-7163.MCT-20-0119

Large Molecule Therapeutics

  • Large Molecule Therapeutics | AuthorChoice
    Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist
    Juan Manuel García-Martínez, Shirley Wang, Cordula Weishaeupl, Andreas Wernitznig, Paolo Chetta, Catarina Pinto, Jason Ho, Darrin Dutcher, Philip N. Gorman, Rachel Kroe-Barrett, Joerg Rinnenthal, Craig Giragossian, Maria Antonietta Impagnatiello, Iñigo Tirapu, Frank Hilberg, Norbert Kraut, Mark Pearson and Klaus Peter Kuenkele
    Mol Cancer Ther January 1 2021 20 (1) 96-108; DOI:10.1158/1535-7163.MCT-20-0253

  • Large Molecule Therapeutics | AuthorChoice
    TriTACs, a Novel Class of T-Cell–Engaging Protein Constructs Designed for the Treatment of Solid Tumors
    Richard J. Austin, Bryan D. Lemon, Wade H. Aaron, Manasi Barath, Patricia A. Culp, Robert B. DuBridge, Luke B. Evnin, Adrie Jones, Anand Panchal, Purbasa Patnaik, Vanitha Ramakrishnan, Sony S. Rocha, Pui Seto, Kenneth Sexton, Kathryn L. Strobel, Russell Wall, Stephen Yu, Timothy Z. Yu, Che-Leung Law, Patrick A. Baeuerle and Holger Wesche
    Mol Cancer Ther January 1 2021 20 (1) 109-120; DOI:10.1158/1535-7163.MCT-20-0061

  • Large Molecule Therapeutics
    Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies
    Julie Preillon, Julia Cuende, Virginie Rabolli, Lucile Garnero, Marjorie Mercier, Noémie Wald, Angela Pappalardo, Sofie Denies, Diane Jamart, Anne-Catherine Michaux, Romain Pirson, Vincent Pitard, Martine Bagot, Shruthi Prasad, Erica Houthuys, Margreet Brouwer, Reece Marillier, Florence Lambolez, Joäo R. Marchante, Florence Nyawouame, Mathew J. Carter, Véronique Baron-Bodo, Anne Marie-Cardine, Mark Cragg, Julie Déchanet-Merville, Gregory Driessens and Catherine Hoofd
    Mol Cancer Ther January 1 2021 20 (1) 121-131; DOI:10.1158/1535-7163.MCT-20-0464

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

  • Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers | AuthorChoice
    Circulating Tumor Cells and Biomarker Modulation with Olaratumab Monotherapy Followed by Olaratumab plus Doxorubicin: Phase Ib Study in Patients with Soft-Tissue Sarcoma
    Javier Martín-Broto, Antonio López Pousa, Andrew S. Brohl, Brian A. Van Tine, Benjamin Powers, Silvia Stacchiotti, Jean-Yves Blay, James S. Hu, Gerard J. Oakley III, Hong Wang, Anna M. Szpurka, Donna E. Levy, Gary Mo, Matteo Ceccarelli and Robin L. Jones
    Mol Cancer Ther January 1 2021 20 (1) 132-141; DOI:10.1158/1535-7163.MCT-20-0441

  • Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
    HLA Polymorphisms Are Associated with Treatment-Free Remission Following Discontinuation of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
    Hiroshi Ureshino, Takero Shindo, Hidenori Tanaka, Hiroh Saji and Shinya Kimura
    Mol Cancer Ther January 1 2021 20 (1) 142-149; DOI:10.1158/1535-7163.MCT-20-0336

Cancer Biology and Translational Studies

  • Cancer Biology and Translational Studies
    Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer
    Yuchen Zhang, Michael B. Ware, Mohammad Y. Zaidi, Amanda N. Ruggieri, Brian M. Olson, Hannah Komar, Matthew R. Farren, Ganji Purnachandra Nagaraju, Chao Zhang, Zhengjia Chen, Juan M. Sarmiento, Rafi Ahmed, Shishir K. Maithel, Bassel F. El-Rayes and Gregory B. Lesinski
    Mol Cancer Ther January 1 2021 20 (1) 150-160; DOI:10.1158/1535-7163.MCT-19-0911

  • Cancer Biology and Translational Studies
    PLK1 and NOTCH Positively Correlate in Melanoma and Their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways
    Shengqin Su, Gagan Chhabra, Mary A. Ndiaye, Chandra K. Singh, Ting Ye, Wei Huang, Colin N. Dewey, Vijayasaradhi Setaluri and Nihal Ahmad
    Mol Cancer Ther January 1 2021 20 (1) 161-172; DOI:10.1158/1535-7163.MCT-20-0654

  • Cancer Biology and Translational Studies
    Recombinant Orthopoxvirus Primes Colon Cancer for Checkpoint Inhibitor and Cross-Primes T Cells for Antitumor and Antiviral Immunity
    Sang-In Kim, Anthony K. Park, Shyambabu Chaurasiya, Seonah Kang, Jianming Lu, Annie Yang, Venkatesh Sivanandam, Zhifang Zhang, Yanghee Woo, Saul J. Priceman, Yuman Fong and Susanne G. Warner
    Mol Cancer Ther January 1 2021 20 (1) 173-182; DOI:10.1158/1535-7163.MCT-20-0405

  • Cancer Biology and Translational Studies
    The Landscape of Glycogen Synthase Kinase-3 Beta Genomic Alterations in Cancer
    Brittany A. Borden, Yasmine Baca, Joanne Xiu, Fabio Tavora, Ira Winer, Benjamin A. Weinberg, Ari M. Vanderwalde, Sourat Darabi, W. Michael Korn, Andrew P. Mazar, Francis J. Giles, Lorin Crawford, Howard Safran, Wafik S. El-Deiry and Benedito A. Carneiro
    Mol Cancer Ther January 1 2021 20 (1) 183-190; DOI:10.1158/1535-7163.MCT-20-0497

  • Cancer Biology and Translational Studies
    IOX1 Suppresses Wnt Target Gene Transcription and Colorectal Cancer Tumorigenesis through Inhibition of KDM3 Histone Demethylases
    Rosalie G. Hoyle, Huiqun Wang, Yana Cen, Yan Zhang and Jiong Li
    Mol Cancer Ther January 1 2021 20 (1) 191-202; DOI:10.1158/1535-7163.MCT-20-0328

Models and Technologies

  • Models and Technologies | AuthorChoice
    Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody–Drug Conjugates to Increase In Vivo Efficacy
    Jose F. Ponte, Leanne Lanieri, Eshita Khera, Rassol Laleau, Olga Ab, Christopher Espelin, Neeraj Kohli, Bahar Matin, Yulius Setiady, Michael L. Miller, Thomas A. Keating, Ravi Chari, Jan Pinkas, Richard Gregory and Greg M. Thurber
    Mol Cancer Ther January 1 2021 20 (1) 203-212; DOI:10.1158/1535-7163.MCT-20-0451

Acknowledgment to Reviewers

  • Acknowledgment to Reviewers | Free Article
    Acknowledgment to Reviewers
    Mol Cancer Ther January 1 2021 20 (1) 213-216; DOI:10.1158/1535-7163.MCT-20-1-reviewers

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Molecular Cancer Therapeutics: 20 (1)
January 2021
Volume 20, Issue 1
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Issue Highlights

  • Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth
  • Targeting PIM Kinases to Overcome Therapeutic Resistance in Cancer
  • HLA Polymorphisms Are Associated with Treatment-Free Remission Following Discontinuation of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
  • Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer

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  • Review
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  • Large Molecule Therapeutics
  • Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
  • Cancer Biology and Translational Studies
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  • Acknowledgment to Reviewers
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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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