In this issue, Wen and colleagues demonstrate that inhibition of the prolactin receptor by G129R initiates FOXO3a-mediated cell death in ovarian cancer. The confocal microscopy image on this month's cover demonstrates treatment with G129 results in nuclear accumulation of FOXO3a (in red) in a uterine cancer cell line. They further demonstrate FOX3a and EIF-4EBP1 play a critical role in the cytotoxic response to G129R. Read the full article on page 1943.