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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Small Molecule Therapeutics

A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer

Charlotte K. Milton, Annette J. Self, Paul A. Clarke, Udai Banerji, Federica Piccioni, David E. Root and Steven R. Whittaker
Charlotte K. Milton
1Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.
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Annette J. Self
1Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.
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Paul A. Clarke
1Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.
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Udai Banerji
1Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.
2The Royal Marsden NHS Foundation Trust, London, United Kingdom.
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Federica Piccioni
3The Broad Institute, Cambridge, Massachusetts.
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David E. Root
3The Broad Institute, Cambridge, Massachusetts.
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Steven R. Whittaker
1Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.
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  • For correspondence: steven.whittaker@gmail.com
DOI: 10.1158/1535-7163.MCT-19-1131 Published July 2020
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Article Information

Volume 19, Issue 7, pp. 1423-1435

DOI 
https://doi.org/10.1158/1535-7163.MCT-19-1131
PubMed 
32371585

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received December 13, 2019
  • Revision received February 17, 2020
  • Accepted April 6, 2020
  • Published first May 5, 2020.

Article Versions

  • Previous version (May 5, 2020 - 07:57).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Charlotte K. Milton1,
  2. Annette J. Self1,
  3. Paul A. Clarke1,
  4. Udai Banerji1,2,
  5. Federica Piccioni3,
  6. David E. Root3, and
  7. Steven R. Whittaker1,*
  1. 1Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.
  2. 2The Royal Marsden NHS Foundation Trust, London, United Kingdom.
  3. 3The Broad Institute, Cambridge, Massachusetts.
  1. ↵*Corresponding Author:
    Steven R. Whittaker, The Institute of Cancer Research, London SW7 3RP, United Kingdom. Phone: 4420-8722-4220; Fax: 4420-8770-7899; E-mail: steven.whittaker{at}gmail.com
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Molecular Cancer Therapeutics: 19 (7)
July 2020
Volume 19, Issue 7
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A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer
Charlotte K. Milton, Annette J. Self, Paul A. Clarke, Udai Banerji, Federica Piccioni, David E. Root and Steven R. Whittaker
Mol Cancer Ther July 1 2020 (19) (7) 1423-1435; DOI: 10.1158/1535-7163.MCT-19-1131

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A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer
Charlotte K. Milton, Annette J. Self, Paul A. Clarke, Udai Banerji, Federica Piccioni, David E. Root and Steven R. Whittaker
Mol Cancer Ther July 1 2020 (19) (7) 1423-1435; DOI: 10.1158/1535-7163.MCT-19-1131
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Molecular Cancer Therapeutics
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