Molecular Cancer Therapeutics: 19 (7)

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Highlights

Selected Articles from This Issue

Mol Cancer Ther July 1 2020 19 (7) 1383-1383;

Small Molecule Therapeutics

Small Molecule Therapeutics | AuthorChoice

MMAE Delivery Using the Bicycle Toxin Conjugate BT5528

Gavin Bennett, Amy Brown, Gemma Mudd, Philip Huxley, Katerine Van Rietschoten, Silvia Pavan, Liuhong Chen, Sophie Watcham, Johanna Lahdenranta and Nicholas Keen

Mol Cancer Ther July 1 2020 19 (7) 1385-1394; DOI:10.1158/1535-7163.MCT-19-1092
Small Molecule Therapeutics | AuthorChoice

The Dysregulated Pharmacology of Clinically Relevant ESR1 Mutants is Normalized by Ligand-activated WT Receptor

Kaitlyn J. Andreano, Jennifer G. Baker, Sunghee Park, Rachid Safi, Sandeep Artham, Steffi Oesterreich, Rinath Jeselsohn, Myles Brown, Sarah Sammons, Suzanne E. Wardell, Ching-yi Chang, John D. Norris and Donald P. McDonnell

Mol Cancer Ther July 1 2020 19 (7) 1395-1405; DOI:10.1158/1535-7163.MCT-19-1148
Small Molecule Therapeutics

Combined Targeting of the BRD4–NUT–p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734

Chevaun D. Morrison-Smith, Tatiana M. Knox, Ivona Filic, Kara M. Soroko, Benjamin K. Eschle, Margaret K. Wilkens, Prafulla C. Gokhale, Francis Giles, Andrew Griffin, Bill Brown, Geoffrey I. Shapiro, Beth E. Zucconi, Philip A. Cole, Madeleine E. Lemieux and Christopher A. French

Mol Cancer Ther July 1 2020 19 (7) 1406-1414; DOI:10.1158/1535-7163.MCT-20-0087
Small Molecule Therapeutics

Perhexiline Demonstrates FYN-mediated Antitumor Activity in Glioblastoma

Shiva Kant, Pravin Kesarwani, Anthony R. Guastella, Praveen Kumar, Stewart F. Graham, Katie L. Buelow, Ichiro Nakano and Prakash Chinnaiyan

Mol Cancer Ther July 1 2020 19 (7) 1415-1422; DOI:10.1158/1535-7163.MCT-19-1047
Small Molecule Therapeutics | AuthorChoice

A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer

Charlotte K. Milton, Annette J. Self, Paul A. Clarke, Udai Banerji, Federica Piccioni, David E. Root and Steven R. Whittaker

Mol Cancer Ther July 1 2020 19 (7) 1423-1435; DOI:10.1158/1535-7163.MCT-19-1131
Small Molecule Therapeutics | AuthorChoice

Targeting the PI3K/AKT Pathway Overcomes Enzalutamide Resistance by Inhibiting Induction of the Glucocorticoid Receptor

Remi Adelaiye-Ogala, Berkley E. Gryder, Yen Thi Minh Nguyen, Aian Neil Alilin, Adlai R. Grayson, Wardah Bajwa, Keith H. Jansson, Michael L. Beshiri, Supreet Agarwal, Jose Antonio Rodriguez-Nieves, Brian Capaldo, Kathleen Kelly and David J. VanderWeele

Mol Cancer Ther July 1 2020 19 (7) 1436-1447; DOI:10.1158/1535-7163.MCT-19-0936
Small Molecule Therapeutics

Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma

Gireesh B. Reddy, David L. Kerr, Ivan Spasojevic, Artak Tovmasyan, David S. Hsu, Brian E. Brigman, Jason A. Somarelli, David Needham and William C. Eward

Mol Cancer Ther July 1 2020 19 (7) 1448-1461; DOI:10.1158/1535-7163.MCT-19-0689
Small Molecule Therapeutics

Rac Signaling Drives Clear Cell Renal Carcinoma Tumor Growth by Priming the Tumor Microenvironment for an Angiogenic Switch

Erik T. Goka, Pallavi Chaturvedi, Dayrelis T. Mesa Lopez and Marc E. Lippman

Mol Cancer Ther July 1 2020 19 (7) 1462-1473; DOI:10.1158/1535-7163.MCT-19-0762

Large Molecule Therapeutics

Large Molecule Therapeutics

Inhibition of Tumor Cell Growth and Cancer Stem Cell Expansion by a Bispecific Antibody Targeting EGFR and HER3

Alexander Rau, Wolfgang S. Lieb, Oliver Seifert, Jonas Honer, Dennis Birnstock, Fabian Richter, Nadine Aschmoneit, Monilola A. Olayioye and Roland E. Kontermann

Mol Cancer Ther July 1 2020 19 (7) 1474-1485; DOI:10.1158/1535-7163.MCT-19-1095

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers | AuthorChoice

Early Assessment of Molecular Progression and Response by Whole-genome Circulating Tumor DNA in Advanced Solid Tumors

Andrew A. Davis, Wade T. Iams, David Chan, Michael S. Oh, Robert W. Lentz, Neil Peterman, Alex Robertson, Abhik Shah, Rohith Srivas, Timothy J. Wilson, Nicole J. Lambert, Peter S. George, Becky Wong, Haleigh W. Wood, Jason C. Close, Ayse Tezcan, Ken Nesmith, Haluk Tezcan and Young Kwang Chae

Mol Cancer Ther July 1 2020 19 (7) 1486-1496; DOI:10.1158/1535-7163.MCT-19-1060
Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

A Qualitative Transcriptional Signature for Predicting Prognosis and Response to Bevacizumab in Metastatic Colorectal Cancer

Jing Yang, Kai Song, Wenbing Guo, Hailong Zheng, Yelin Fu, Tianyi You, Kai Wang, Lishuang Qi, Wenyuan Zhao and Zheng Guo

Mol Cancer Ther July 1 2020 19 (7) 1497-1505; DOI:10.1158/1535-7163.MCT-19-0864

Cancer Biology and Translational Studies

Cancer Biology and Translational Studies

Functional miRNA Screening Identifies Wide-ranging Antitumor Properties of miR-3622b-5p and Reveals a New Therapeutic Combination Strategy in Ovarian Tumor Organoids

Mégane Vernon, Bernard Lambert, Matthieu Meryet-Figuière, Emilie Brotin, Louis-Bastien Weiswald, Hippolyte Paysant, Nicolas Vigneron, Anaïs Wambecke, Edwige Abeilard, Florence Giffard, Marie-Hélène Louis, Cécile Blanc-Fournier, Pascal Gauduchon, Laurent Poulain and Christophe Denoyelle

Mol Cancer Ther July 1 2020 19 (7) 1506-1519; DOI:10.1158/1535-7163.MCT-19-0510
Cancer Biology and Translational Studies

EWS-FLI1–regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth

Sameer H. Issaq, Arnulfo Mendoza, Ria Kidner, Tracy I. Rosales, Damien Y. Duveau, Christine M. Heske, Jason M. Rohde, Matthew B. Boxer, Craig J. Thomas, Ralph J. DeBerardinis and Lee J. Helman

Mol Cancer Ther July 1 2020 19 (7) 1520-1529; DOI:10.1158/1535-7163.MCT-19-0748
Cancer Biology and Translational Studies

A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma

Marina Li, Cindy Lin, Hui Deng, Joann Strnad, Luca Bernabei, Dan T. Vogl, James J. Burke and Yulia Nefedova

Mol Cancer Ther July 1 2020 19 (7) 1530-1538; DOI:10.1158/1535-7163.MCT-19-1020
Cancer Biology and Translational Studies | AuthorChoice

DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization

Parthasarathy Chandrakesan, Janani Panneerselvam, Randal May, Nathaniel Weygant, Dongfeng Qu, William R. Berry, Kamille Pitts, Ben Z. Stanger, Chinthalapally V. Rao, Michael S. Bronze and Courtney W. Houchen

Mol Cancer Ther July 1 2020 19 (7) 1539-1549; DOI:10.1158/1535-7163.MCT-19-0776
Cancer Biology and Translational Studies

Blockade of Cell Volume Regulatory Protein NKCC1 Increases TMZ-Induced Glioma Apoptosis and Reduces Astrogliosis

Lanxin Luo, Xiudong Guan, Gulnaz Begum, Dawei Ding, Jenesis Gayden, Md Nabiul Hasan, Victoria M. Fiesler, Jacob Dodelson, Gary Kohanbash, Baoli Hu, Nduka M. Amankulor, Wang Jia, Maria G. Castro, Baoshan Sun and Dandan Sun

Mol Cancer Ther July 1 2020 19 (7) 1550-1561; DOI:10.1158/1535-7163.MCT-19-0910
Cancer Biology and Translational Studies

Pathway-Specific Genome Editing of PI3K/mTOR Tumor Suppressor Genes Reveals that PTEN Loss Contributes to Cetuximab Resistance in Head and Neck Cancer

Hiroki Izumi, Zhiyong Wang, Yusuke Goto, Toshinori Ando, Xingyu Wu, Xuefeng Zhang, Hua Li, Daniel E. Johnson, Jennifer R. Grandis and J. Silvio Gutkind

Mol Cancer Ther July 1 2020 19 (7) 1562-1571; DOI:10.1158/1535-7163.MCT-19-1036

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Small Molecule Therapeutics

Large Molecule Therapeutics

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

Cancer Biology and Translational Studies

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