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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Highlights

  • Highlights
    Selected Articles from This Issue
    Mol Cancer Ther July 1 2020 19 (7) 1383-1383;

MCT First Disclosures

  • MMAE Delivery Using the <em>Bicycle</em> Toxin Conjugate BT5528
    MCT First Disclosures | AuthorChoice
    MMAE Delivery Using the Bicycle Toxin Conjugate BT5528
    Gavin Bennett, Amy Brown, Gemma Mudd, Philip Huxley, Katerine Van Rietschoten, Silvia Pavan, Liuhong Chen, Sophie Watcham, Johanna Lahdenranta and Nicholas Keen
    Mol Cancer Ther July 1 2020 19 (7) 1385-1394; DOI:10.1158/1535-7163.MCT-19-1092

Small Molecule Therapeutics

  • Small Molecule Therapeutics | AuthorChoice
    The Dysregulated Pharmacology of Clinically Relevant ESR1 Mutants is Normalized by Ligand-activated WT Receptor
    Kaitlyn J. Andreano, Jennifer G. Baker, Sunghee Park, Rachid Safi, Sandeep Artham, Steffi Oesterreich, Rinath Jeselsohn, Myles Brown, Sarah Sammons, Suzanne E. Wardell, Ching-yi Chang, John D. Norris and Donald P. McDonnell
    Mol Cancer Ther July 1 2020 19 (7) 1395-1405; DOI:10.1158/1535-7163.MCT-19-1148

  • Small Molecule Therapeutics
    Combined Targeting of the BRD4–NUT–p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734
    Chevaun D. Morrison-Smith, Tatiana M. Knox, Ivona Filic, Kara M. Soroko, Benjamin K. Eschle, Margaret K. Wilkens, Prafulla C. Gokhale, Francis Giles, Andrew Griffin, Bill Brown, Geoffrey I. Shapiro, Beth E. Zucconi, Philip A. Cole, Madeleine E. Lemieux and Christopher A. French
    Mol Cancer Ther July 1 2020 19 (7) 1406-1414; DOI:10.1158/1535-7163.MCT-20-0087

  • Small Molecule Therapeutics
    Perhexiline Demonstrates FYN-mediated Antitumor Activity in Glioblastoma
    Shiva Kant, Pravin Kesarwani, Anthony R. Guastella, Praveen Kumar, Stewart F. Graham, Katie L. Buelow, Ichiro Nakano and Prakash Chinnaiyan
    Mol Cancer Ther July 1 2020 19 (7) 1415-1422; DOI:10.1158/1535-7163.MCT-19-1047

  • Small Molecule Therapeutics | AuthorChoice
    A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer
    Charlotte K. Milton, Annette J. Self, Paul A. Clarke, Udai Banerji, Federica Piccioni, David E. Root and Steven R. Whittaker
    Mol Cancer Ther July 1 2020 19 (7) 1423-1435; DOI:10.1158/1535-7163.MCT-19-1131

  • Small Molecule Therapeutics | AuthorChoice
    Targeting the PI3K/AKT Pathway Overcomes Enzalutamide Resistance by Inhibiting Induction of the Glucocorticoid Receptor
    Remi Adelaiye-Ogala, Berkley E. Gryder, Yen Thi Minh Nguyen, Aian Neil Alilin, Adlai R. Grayson, Wardah Bajwa, Keith H. Jansson, Michael L. Beshiri, Supreet Agarwal, Jose Antonio Rodriguez-Nieves, Brian Capaldo, Kathleen Kelly and David J. VanderWeele
    Mol Cancer Ther July 1 2020 19 (7) 1436-1447; DOI:10.1158/1535-7163.MCT-19-0936

  • Small Molecule Therapeutics
    Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma
    Gireesh B. Reddy, David L. Kerr, Ivan Spasojevic, Artak Tovmasyan, David S. Hsu, Brian E. Brigman, Jason A. Somarelli, David Needham and William C. Eward
    Mol Cancer Ther July 1 2020 19 (7) 1448-1461; DOI:10.1158/1535-7163.MCT-19-0689

  • Small Molecule Therapeutics
    Rac Signaling Drives Clear Cell Renal Carcinoma Tumor Growth by Priming the Tumor Microenvironment for an Angiogenic Switch
    Erik T. Goka, Pallavi Chaturvedi, Dayrelis T. Mesa Lopez and Marc E. Lippman
    Mol Cancer Ther July 1 2020 19 (7) 1462-1473; DOI:10.1158/1535-7163.MCT-19-0762

Large Molecule Therapeutics

  • Large Molecule Therapeutics
    Inhibition of Tumor Cell Growth and Cancer Stem Cell Expansion by a Bispecific Antibody Targeting EGFR and HER3
    Alexander Rau, Wolfgang S. Lieb, Oliver Seifert, Jonas Honer, Dennis Birnstock, Fabian Richter, Nadine Aschmoneit, Monilola A. Olayioye and Roland E. Kontermann
    Mol Cancer Ther July 1 2020 19 (7) 1474-1485; DOI:10.1158/1535-7163.MCT-19-1095

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

  • Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers | AuthorChoice
    Early Assessment of Molecular Progression and Response by Whole-genome Circulating Tumor DNA in Advanced Solid Tumors
    Andrew A. Davis, Wade T. Iams, David Chan, Michael S. Oh, Robert W. Lentz, Neil Peterman, Alex Robertson, Abhik Shah, Rohith Srivas, Timothy J. Wilson, Nicole J. Lambert, Peter S. George, Becky Wong, Haleigh W. Wood, Jason C. Close, Ayse Tezcan, Ken Nesmith, Haluk Tezcan and Young Kwang Chae
    Mol Cancer Ther July 1 2020 19 (7) 1486-1496; DOI:10.1158/1535-7163.MCT-19-1060

  • Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
    A Qualitative Transcriptional Signature for Predicting Prognosis and Response to Bevacizumab in Metastatic Colorectal Cancer
    Jing Yang, Kai Song, Wenbing Guo, Hailong Zheng, Yelin Fu, Tianyi You, Kai Wang, Lishuang Qi, Wenyuan Zhao and Zheng Guo
    Mol Cancer Ther July 1 2020 19 (7) 1497-1505; DOI:10.1158/1535-7163.MCT-19-0864

Cancer Biology and Translational Studies

  • Cancer Biology and Translational Studies
    Functional miRNA Screening Identifies Wide-ranging Antitumor Properties of miR-3622b-5p and Reveals a New Therapeutic Combination Strategy in Ovarian Tumor Organoids
    Mégane Vernon, Bernard Lambert, Matthieu Meryet-Figuière, Emilie Brotin, Louis-Bastien Weiswald, Hippolyte Paysant, Nicolas Vigneron, Anaïs Wambecke, Edwige Abeilard, Florence Giffard, Marie-Hélène Louis, Cécile Blanc-Fournier, Pascal Gauduchon, Laurent Poulain and Christophe Denoyelle
    Mol Cancer Ther July 1 2020 19 (7) 1506-1519; DOI:10.1158/1535-7163.MCT-19-0510

  • Cancer Biology and Translational Studies
    EWS-FLI1–regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth
    Sameer H. Issaq, Arnulfo Mendoza, Ria Kidner, Tracy I. Rosales, Damien Y. Duveau, Christine M. Heske, Jason M. Rohde, Matthew B. Boxer, Craig J. Thomas, Ralph J. DeBerardinis and Lee J. Helman
    Mol Cancer Ther July 1 2020 19 (7) 1520-1529; DOI:10.1158/1535-7163.MCT-19-0748

  • Cancer Biology and Translational Studies
    A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma
    Marina Li, Cindy Lin, Hui Deng, Joann Strnad, Luca Bernabei, Dan T. Vogl, James J. Burke and Yulia Nefedova
    Mol Cancer Ther July 1 2020 19 (7) 1530-1538; DOI:10.1158/1535-7163.MCT-19-1020

  • Cancer Biology and Translational Studies | AuthorChoice
    DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization
    Parthasarathy Chandrakesan, Janani Panneerselvam, Randal May, Nathaniel Weygant, Dongfeng Qu, William R. Berry, Kamille Pitts, Ben Z. Stanger, Chinthalapally V. Rao, Michael S. Bronze and Courtney W. Houchen
    Mol Cancer Ther July 1 2020 19 (7) 1539-1549; DOI:10.1158/1535-7163.MCT-19-0776

  • Cancer Biology and Translational Studies
    Blockade of Cell Volume Regulatory Protein NKCC1 Increases TMZ-Induced Glioma Apoptosis and Reduces Astrogliosis
    Lanxin Luo, Xiudong Guan, Gulnaz Begum, Dawei Ding, Jenesis Gayden, Md Nabiul Hasan, Victoria M. Fiesler, Jacob Dodelson, Gary Kohanbash, Baoli Hu, Nduka M. Amankulor, Wang Jia, Maria G. Castro, Baoshan Sun and Dandan Sun
    Mol Cancer Ther July 1 2020 19 (7) 1550-1561; DOI:10.1158/1535-7163.MCT-19-0910

  • Cancer Biology and Translational Studies
    Pathway-Specific Genome Editing of PI3K/mTOR Tumor Suppressor Genes Reveals that PTEN Loss Contributes to Cetuximab Resistance in Head and Neck Cancer
    Hiroki Izumi, Zhiyong Wang, Yusuke Goto, Toshinori Ando, Xingyu Wu, Xuefeng Zhang, Hua Li, Daniel E. Johnson, Jennifer R. Grandis and J. Silvio Gutkind
    Mol Cancer Ther July 1 2020 19 (7) 1562-1571; DOI:10.1158/1535-7163.MCT-19-1036

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Molecular Cancer Therapeutics: 19 (7)
July 2020
Volume 19, Issue 7
  • Table of Contents
  • Table of Contents (PDF)
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Issue Highlights

  • MMAE Delivery Using the Bicycle Toxin Conjugate BT5528
  • Functional miRNA Screening Identifies Wide-ranging Antitumor Properties of miR-3622b-5p and Reveals a New Therapeutic Combination Strategy in Ovarian Tumor Organoids
  • The Dysregulated Pharmacology of Clinically Relevant ESR1 Mutants is Normalized by Ligand-activated WT Receptor
  • Combined Targeting of the BRD4–NUT–p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734

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  • MCT First Disclosures
  • Small Molecule Therapeutics
  • Large Molecule Therapeutics
  • Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
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  • CD137 Agonist mAb with Reduced Liver Toxicity
  • Truncated BRCA2 Contributes to PARPi Resistance
  • ERPAS to Predict Response to Endocrine Therapy
  • CDK8/19 Inhibitors Enhance NK-Cell–Mediated Cancer Therapy
  • Sialoglycan mAb for Cancer Immunotherapy
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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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