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Molecular Cancer Therapeutics
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Large Molecule Therapeutics

Effect of Modulating FcRn Binding on Direct and Pretargeted Tumor Uptake of Full-length Antibodies

Lidia Nazarova, Hanine Rafidi, Danielle Mandikian, Gregory Z. Ferl, James T. Koerber, Christopher W. Davies, Sheila Ulufatu, Jason Ho, Jeffrey Lau, Shang-Fan Yu, James Ernst, Jack D. Sadowsky and C. Andrew Boswell
Lidia Nazarova
1Preclinical and Translational Pharmacokinetics, Genentech Research and Early Development, South San Francisco, California.
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  • ORCID record for Lidia Nazarova
Hanine Rafidi
1Preclinical and Translational Pharmacokinetics, Genentech Research and Early Development, South San Francisco, California.
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Danielle Mandikian
1Preclinical and Translational Pharmacokinetics, Genentech Research and Early Development, South San Francisco, California.
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Gregory Z. Ferl
1Preclinical and Translational Pharmacokinetics, Genentech Research and Early Development, South San Francisco, California.
2Biomedical Imaging, Genentech Research and Early Development, South San Francisco, California.
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  • ORCID record for Gregory Z. Ferl
James T. Koerber
3Antibody Engineering, Genentech Research and Early Development, South San Francisco, California.
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  • ORCID record for James T. Koerber
Christopher W. Davies
3Antibody Engineering, Genentech Research and Early Development, South San Francisco, California.
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Sheila Ulufatu
4In Vivo Studies, Genentech Research and Early Development, South San Francisco, California.
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Jason Ho
4In Vivo Studies, Genentech Research and Early Development, South San Francisco, California.
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Jeffrey Lau
5Translational Oncology, Genentech Research and Early Development, South San Francisco, California.
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Shang-Fan Yu
5Translational Oncology, Genentech Research and Early Development, South San Francisco, California.
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James Ernst
6Protein Chemistry, Genentech Research and Early Development, South San Francisco, California.
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Jack D. Sadowsky
6Protein Chemistry, Genentech Research and Early Development, South San Francisco, California.
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C. Andrew Boswell
1Preclinical and Translational Pharmacokinetics, Genentech Research and Early Development, South San Francisco, California.
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  • For correspondence: boswell.andy@gene.com
DOI: 10.1158/1535-7163.MCT-19-1015 Published April 2020
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Article Information

Volume 19, Issue 4, pp. 1052-1058

DOI 
https://doi.org/10.1158/1535-7163.MCT-19-1015
PubMed 
32024685

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received October 24, 2019
  • Revision received January 7, 2020
  • Accepted January 28, 2020
  • Published first February 5, 2020.

Article Versions

  • Previous version (February 5, 2020 - 07:17).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Lidia Nazarova1,#,
  2. Hanine Rafidi1,#,
  3. Danielle Mandikian1,
  4. Gregory Z. Ferl1,2,
  5. James T. Koerber3,
  6. Christopher W. Davies3,
  7. Sheila Ulufatu4,
  8. Jason Ho4,
  9. Jeffrey Lau5,
  10. Shang-Fan Yu5,
  11. James Ernst6,
  12. Jack D. Sadowsky6, and
  13. C. Andrew Boswell1,*
  1. 1Preclinical and Translational Pharmacokinetics, Genentech Research and Early Development, South San Francisco, California.
  2. 2Biomedical Imaging, Genentech Research and Early Development, South San Francisco, California.
  3. 3Antibody Engineering, Genentech Research and Early Development, South San Francisco, California.
  4. 4In Vivo Studies, Genentech Research and Early Development, South San Francisco, California.
  5. 5Translational Oncology, Genentech Research and Early Development, South San Francisco, California.
  6. 6Protein Chemistry, Genentech Research and Early Development, South San Francisco, California.
  1. ↵*Corresponding Author:
    C. Andrew Boswell, Genentech Inc., 1 DNA Way, MS 463A, South San Francisco, CA 94080. Phone: 650-467-4603; Fax: 650-742-5234; E-mail: boswell.andy{at}gene.com
  1. ↵#L. Nazarova and H. Rafidi contributed equally to this article.

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Molecular Cancer Therapeutics: 19 (4)
April 2020
Volume 19, Issue 4
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Effect of Modulating FcRn Binding on Direct and Pretargeted Tumor Uptake of Full-length Antibodies
Lidia Nazarova, Hanine Rafidi, Danielle Mandikian, Gregory Z. Ferl, James T. Koerber, Christopher W. Davies, Sheila Ulufatu, Jason Ho, Jeffrey Lau, Shang-Fan Yu, James Ernst, Jack D. Sadowsky and C. Andrew Boswell
Mol Cancer Ther April 1 2020 (19) (4) 1052-1058; DOI: 10.1158/1535-7163.MCT-19-1015

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Effect of Modulating FcRn Binding on Direct and Pretargeted Tumor Uptake of Full-length Antibodies
Lidia Nazarova, Hanine Rafidi, Danielle Mandikian, Gregory Z. Ferl, James T. Koerber, Christopher W. Davies, Sheila Ulufatu, Jason Ho, Jeffrey Lau, Shang-Fan Yu, James Ernst, Jack D. Sadowsky and C. Andrew Boswell
Mol Cancer Ther April 1 2020 (19) (4) 1052-1058; DOI: 10.1158/1535-7163.MCT-19-1015
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