In this issue of Molecular Cancer Therapeutics, we present the first two examples of the new "First Disclosures" article type. This article type is designed to highlight the first-time disclosure of oncology drug structures and their preclinical profiles. The cover image, taken from our large molecule example, demonstrates the proposed complex structure of the variable region of the CD137 agonist 7A5 (in red cartoon) with CD137 (in white). The CD137L binding site is also shown in blue. Read the full disclosure of the 7A5 antibody on page 988.