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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

Cover image

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In this issue of Molecular Cancer Therapeutics, we present the first two examples of the new "First Disclosures" article type. This article type is designed to highlight the first-time disclosure of oncology drug structures and their preclinical profiles. The cover image, taken from our large molecule example, demonstrates the proposed complex structure of the variable region of the CD137 agonist 7A5 (in red cartoon) with CD137 (in white). The CD137L binding site is also shown in blue. Read the full disclosure of the 7A5 antibody on page 988.

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Molecular Cancer Therapeutics: 19 (4)
April 2020
Volume 19, Issue 4
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Issue Highlights

  • Preclinical Activity of HER2-Selective Tyrosine Kinase Inhibitor Tucatinib as a Single Agent or in Combination with Trastuzumab or Docetaxel in Solid Tumor Models
  • Characterization of 7A5: A Human CD137 (4-1BB) Receptor Binding Monoclonal Antibody with Differential Agonist Properties That Promotes Antitumor Immunity
  • A Historic Perspective and Overview of H-Ras Structure, Oncogenicity, and Targeting
  • Oxaliplatin–DNA Adducts as Predictive Biomarkers of FOLFOX Response in Colorectal Cancer: A Potential Treatment Optimization Strategy
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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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