Phosphodiesterase 3A Represents a Therapeutic Target that Drives Stem Cell–like Property and Metastasis in Breast Cancer

Na Hao; Wenzhi Shen; Renle Du; Shan Jiang; Junyong Zhu; Yanan Chen; Chongbiao Huang; Yi Shi; Rong Xiang; Yunping Luo

doi:10.1158/1535-7163.MCT-18-1233

Cancer Biology and Translational Studies

Phosphodiesterase 3A Represents a Therapeutic Target that Drives Stem Cell–like Property and Metastasis in Breast Cancer

Na Hao, Wenzhi Shen, Renle Du, Shan Jiang, Junyong Zhu, Yanan Chen, Chongbiao Huang, Yi Shi, Rong Xiang and Yunping Luo

Na Hao

1Department of Breast Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

2Department of Immunology, School of Medicine, Nankai University, Tianjin, China.

3Department of Immunology, Institute of Basic Medical Science, Chinese Academy of Medical Science, School of Basic Medicine Peking Union Medical College, Beijing, China.

4International Joint Center for Biomedical Research of the Ministry of Education, Tianjin, China.

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Wenzhi Shen

2Department of Immunology, School of Medicine, Nankai University, Tianjin, China.

3Department of Immunology, Institute of Basic Medical Science, Chinese Academy of Medical Science, School of Basic Medicine Peking Union Medical College, Beijing, China.

5Department of Pathology and Institute of Precision Medicine, Jining Medical University, Jining, China.

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Renle Du

1Department of Breast Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

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Shan Jiang

1Department of Breast Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

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Junyong Zhu

6Department of Galactophore, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.

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Yanan Chen

1Department of Breast Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

3Department of Immunology, Institute of Basic Medical Science, Chinese Academy of Medical Science, School of Basic Medicine Peking Union Medical College, Beijing, China.

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Chongbiao Huang

7Senior Ward, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research, Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.

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Yi Shi

1Department of Breast Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

3Department of Immunology, Institute of Basic Medical Science, Chinese Academy of Medical Science, School of Basic Medicine Peking Union Medical College, Beijing, China.

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ORCID record for Yi Shi

Rong Xiang

1Department of Breast Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

3Department of Immunology, Institute of Basic Medical Science, Chinese Academy of Medical Science, School of Basic Medicine Peking Union Medical College, Beijing, China.

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Yunping Luo

2Department of Immunology, School of Medicine, Nankai University, Tianjin, China.

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For correspondence: ypluo@ibms.pumc.edu.cn

DOI: 10.1158/1535-7163.MCT-18-1233 Published March 2020

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March 2020
Volume 19, Issue 3

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Phosphodiesterase 3A Represents a Therapeutic Target that Drives Stem Cell–like Property and Metastasis in Breast Cancer

Na Hao, Wenzhi Shen, Renle Du, Shan Jiang, Junyong Zhu, Yanan Chen, Chongbiao Huang, Yi Shi, Rong Xiang and Yunping Luo

Mol Cancer Ther March 1 2020 (19) (3) 868-881; DOI: 10.1158/1535-7163.MCT-18-1233

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Phosphodiesterase 3A Represents a Therapeutic Target that Drives Stem Cell–like Property and Metastasis in Breast Cancer

Na Hao, Wenzhi Shen, Renle Du, Shan Jiang, Junyong Zhu, Yanan Chen, Chongbiao Huang, Yi Shi, Rong Xiang and Yunping Luo

Mol Cancer Ther March 1 2020 (19) (3) 868-881; DOI: 10.1158/1535-7163.MCT-18-1233

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