Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma

Jeremy J.P. Shaw; Timothy L. Boyer; Emily Venner; Patrick J. Beck; Tristen Slamowitz; Tara Caste; Alexandra Hickman; Michael H. Raymond; Pedro Costa-Pinheiro; Mark J. Jameson; Todd E. Fox; Mark Kester

doi:10.1158/1535-7163.MCT-20-0182

Cancer Biology and Translational Studies

Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma

Jeremy J.P. Shaw, Timothy L. Boyer, Emily Venner, Patrick J. Beck, Tristen Slamowitz, Tara Caste, Alexandra Hickman, Michael H. Raymond, Pedro Costa-Pinheiro, Mark J. Jameson, Todd E. Fox and Mark Kester

Jeremy J.P. Shaw

1Department of Pathology, University of Virginia, Charlottesville, Virginia.

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Timothy L. Boyer

2Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.

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Emily Venner

3Department of Biology, University of Virginia, Charlottesville, Virginia.

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Patrick J. Beck

2Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.

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Tristen Slamowitz

2Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.

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Tara Caste

2Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.

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Alexandra Hickman

2Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.

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Michael H. Raymond

4Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia.

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Pedro Costa-Pinheiro

1Department of Pathology, University of Virginia, Charlottesville, Virginia.

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Mark J. Jameson

5Department of Otolaryngology–Head and Neck Surgery, University of Virginia, Charlottesville, Virginia.

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Todd E. Fox

6Department of Pharmacology, University of Virginia, Charlottesville, Virginia.

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Mark Kester

2Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.

6Department of Pharmacology, University of Virginia, Charlottesville, Virginia.

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For correspondence: mkester@virginia.edu

DOI: 10.1158/1535-7163.MCT-20-0182 Published December 2020

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December 2020
Volume 19, Issue 12

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Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma

Mol Cancer Ther December 1 2020 (19) (12) 2621-2633; DOI: 10.1158/1535-7163.MCT-20-0182

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Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma