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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Cancer Biology and Translational Studies

Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma

Jeremy J.P. Shaw, Timothy L. Boyer, Emily Venner, Patrick J. Beck, Tristen Slamowitz, Tara Caste, Alexandra Hickman, Michael H. Raymond, Pedro Costa-Pinheiro, Mark J. Jameson, Todd E. Fox and Mark Kester
Jeremy J.P. Shaw
1Department of Pathology, University of Virginia, Charlottesville, Virginia.
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Timothy L. Boyer
2Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
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Emily Venner
3Department of Biology, University of Virginia, Charlottesville, Virginia.
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Patrick J. Beck
2Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
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Tristen Slamowitz
2Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
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Tara Caste
2Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
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Alexandra Hickman
2Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
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Michael H. Raymond
4Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia.
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Pedro Costa-Pinheiro
1Department of Pathology, University of Virginia, Charlottesville, Virginia.
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  • ORCID record for Pedro Costa-Pinheiro
Mark J. Jameson
5Department of Otolaryngology–Head and Neck Surgery, University of Virginia, Charlottesville, Virginia.
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Todd E. Fox
6Department of Pharmacology, University of Virginia, Charlottesville, Virginia.
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  • ORCID record for Todd E. Fox
Mark Kester
2Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
6Department of Pharmacology, University of Virginia, Charlottesville, Virginia.
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  • For correspondence: mkester@virginia.edu
DOI: 10.1158/1535-7163.MCT-20-0182 Published December 2020
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Article Information

Volume 19, Issue 12, pp. 2621-2633

DOI 
https://doi.org/10.1158/1535-7163.MCT-20-0182
PubMed 
33087509

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received March 16, 2020
  • Revision received July 3, 2020
  • Accepted September 28, 2020
  • Published first October 21, 2020.

Article Versions

  • Previous version (October 21, 2020 - 07:32).
  • You are viewing the most recent version of this article.
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©2020 American Association for Cancer Research.

Author Information

  1. Jeremy J.P. Shaw1,
  2. Timothy L. Boyer2,
  3. Emily Venner3,
  4. Patrick J. Beck2,
  5. Tristen Slamowitz2,
  6. Tara Caste2,
  7. Alexandra Hickman2,
  8. Michael H. Raymond4,
  9. Pedro Costa-Pinheiro1,
  10. Mark J. Jameson5,
  11. Todd E. Fox6, and
  12. Mark Kester2,6,*
  1. 1Department of Pathology, University of Virginia, Charlottesville, Virginia.
  2. 2Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
  3. 3Department of Biology, University of Virginia, Charlottesville, Virginia.
  4. 4Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia.
  5. 5Department of Otolaryngology–Head and Neck Surgery, University of Virginia, Charlottesville, Virginia.
  6. 6Department of Pharmacology, University of Virginia, Charlottesville, Virginia.
  1. ↵*Corresponding Author:
    Mark Kester, Department of Pharmacology, University of Virginia, 1340 Jefferson Park Avenue, Pinn Hall P.O. Box 800735, Charlottesville, VA 22908. Phone: 717-503-6973; E-mail: mkester{at}virginia.edu
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Molecular Cancer Therapeutics: 19 (12)
December 2020
Volume 19, Issue 12
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Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Jeremy J.P. Shaw, Timothy L. Boyer, Emily Venner, Patrick J. Beck, Tristen Slamowitz, Tara Caste, Alexandra Hickman, Michael H. Raymond, Pedro Costa-Pinheiro, Mark J. Jameson, Todd E. Fox and Mark Kester
Mol Cancer Ther December 1 2020 (19) (12) 2621-2633; DOI: 10.1158/1535-7163.MCT-20-0182

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Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Jeremy J.P. Shaw, Timothy L. Boyer, Emily Venner, Patrick J. Beck, Tristen Slamowitz, Tara Caste, Alexandra Hickman, Michael H. Raymond, Pedro Costa-Pinheiro, Mark J. Jameson, Todd E. Fox and Mark Kester
Mol Cancer Ther December 1 2020 (19) (12) 2621-2633; DOI: 10.1158/1535-7163.MCT-20-0182
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