Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K–AKT Signaling for the Treatment of Metastatic Osteosarcoma

Branden A. Smeester; Garrett M. Draper; Nicholas J. Slipek; Alex T. Larsson; Natalie Stratton; Emily J. Pomeroy; Kelsie L. Becklin; Kenta Yamamoto; Kyle B. Williams; Kanut Laoharawee; Joseph J. Peterson; Juan E. Abrahante; Susan K. Rathe; Lauren J. Mills; Margaret R. Crosby; Wendy A. Hudson; Eric P. Rahrmann; David A. Largaespada; Branden S. Moriarity

doi:10.1158/1535-7163.MCT-20-0369

Small Molecule Therapeutics

Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K–AKT Signaling for the Treatment of Metastatic Osteosarcoma

Branden A. Smeester, Garrett M. Draper, Nicholas J. Slipek, Alex T. Larsson, Natalie Stratton, Emily J. Pomeroy, Kelsie L. Becklin, Kenta Yamamoto, Kyle B. Williams, Kanut Laoharawee, Joseph J. Peterson, Juan E. Abrahante, Susan K. Rathe, Lauren J. Mills, Margaret R. Crosby, Wendy A. Hudson, Eric P. Rahrmann, David A. Largaespada and Branden S. Moriarity

Branden A. Smeester

1Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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Garrett M. Draper

1Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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Nicholas J. Slipek

2Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.

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Alex T. Larsson

2Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.

3Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota.

4Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.

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Natalie Stratton

1Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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Emily J. Pomeroy

1Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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Kelsie L. Becklin

1Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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Kenta Yamamoto

1Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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Kyle B. Williams

1Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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Kanut Laoharawee

1Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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Joseph J. Peterson

1Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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Juan E. Abrahante

5UMII, University of Minnesota, Minneapolis, Minnesota.

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Susan K. Rathe

4Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.

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Lauren J. Mills

1Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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Margaret R. Crosby

1Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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Wendy A. Hudson

6AHCSH Cancer Center, University of Minnesota, Minneapolis, Minnesota.

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Eric P. Rahrmann

7Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, England.

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David A. Largaespada

1Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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Branden S. Moriarity

1Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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For correspondence: mori0164@umn.edu

DOI: 10.1158/1535-7163.MCT-20-0369 Published December 2020

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December 2020
Volume 19, Issue 12

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Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K–AKT Signaling for the Treatment of Metastatic Osteosarcoma

Mol Cancer Ther December 1 2020 (19) (12) 2528-2541; DOI: 10.1158/1535-7163.MCT-20-0369

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Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K–AKT Signaling for the Treatment of Metastatic Osteosarcoma