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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Highlights

  • Highlights
    Selected Articles from This Issue
    Mol Cancer Ther December 1 2020 19 (12) 2407-2407;

Review

  • Review | AuthorChoice
    Emerging CAR-T Cell Therapy for the Treatment of Triple-Negative Breast Cancer
    Sundee Dees, Rajkumar Ganesan, Sanjaya Singh and Iqbal S. Grewal
    Mol Cancer Ther December 1 2020 19 (12) 2409-2421; DOI:10.1158/1535-7163.MCT-20-0385

Small Molecule Therapeutics

  • Small Molecule Therapeutics
    ASR490, a Small Molecule, Overrides Aberrant Expression of Notch1 in Colorectal Cancer
    Ashish Tyagi, Balaji Chandrasekaran, Venkatesh Kolluru, Becca V. Baby, Cibi A. Sripathi, Murali K. Ankem, Srinivasa R. Ramisetti, Venkat R. Chirasani, Nikolay V. Dokholyan, Arun K. Sharma and Chendil Damodaran
    Mol Cancer Ther December 1 2020 19 (12) 2422-2431; DOI:10.1158/1535-7163.MCT-19-0949

  • Small Molecule Therapeutics
    Development of Tumor-Targeting IRE-1 Inhibitors for B-cell Cancer Therapy
    Andong Shao, Qin Xu, Walker T. Spalek, Christopher F. Cain, Chang Won Kang, Chih-Hang Anthony Tang, Juan R. Del Valle and Chih-Chi Andrew Hu
    Mol Cancer Ther December 1 2020 19 (12) 2432-2444; DOI:10.1158/1535-7163.MCT-20-0127

  • Small Molecule Therapeutics
    MP-Pt(IV): A MAOB-Sensitive Mitochondrial-Specific Prodrug for Treating Glioblastoma
    Sudhir Raghavan, David S. Baskin and Martyn A. Sharpe
    Mol Cancer Ther December 1 2020 19 (12) 2445-2453; DOI:10.1158/1535-7163.MCT-20-0420

  • Small Molecule Therapeutics | AuthorChoice
    Repurposing of a Thromboxane Receptor Inhibitor Based on a Novel Role in Metastasis Identified by Phenome-Wide Association Study
    Thomas A. Werfel, Donna J. Hicks, Bushra Rahman, Wendy E. Bendeman, Matthew T. Duvernay, Jae G. Maeng, Heidi Hamm, Robert R. Lavieri, Meghan M. Joly, Jill M. Pulley, David L. Elion, Dana M. Brantley-Sieders and Rebecca S. Cook
    Mol Cancer Ther December 1 2020 19 (12) 2454-2464; DOI:10.1158/1535-7163.MCT-19-1106

  • Small Molecule Therapeutics
    Glutaminase Inhibitors Induce Thiol-Mediated Oxidative Stress and Radiosensitization in Treatment-Resistant Cervical Cancers
    Ramachandran Rashmi, Kay Jayachandran, Jin Zhang, Vishnu Menon, Naoshad Muhammad, Michael Zahner, Fiona Ruiz, Sisi Zhang, Kevin Cho, Yuting Wang, Xiaojing Huang, Yi Huang, Michael L. McCormick, Buck E. Rogers, Douglas R. Spitz, Gary J. Patti and Julie K. Schwarz
    Mol Cancer Ther December 1 2020 19 (12) 2465-2475; DOI:10.1158/1535-7163.MCT-20-0271

  • Small Molecule Therapeutics | AuthorChoice
    HIV Protease Inhibitors Block HPV16-Induced Murine Cervical Carcinoma and Promote Vessel Normalization in Association with MMP-9 Inhibition and TIMP-3 Induction
    Yaqi Qiu, Federica Maione, Stefania Capano, Claudia Meda, Orietta Picconi, Serena Brundu, Alberto Pisacane, Anna Sapino, Clelia Palladino, Giovanni Barillari, Paolo Monini, Federico Bussolino, Barbara Ensoli, Cecilia Sgadari and Enrico Giraudo
    Mol Cancer Ther December 1 2020 19 (12) 2476-2489; DOI:10.1158/1535-7163.MCT-20-0055

  • Small Molecule Therapeutics | AuthorChoice
    Inhibition of EZH2 Enhances the Antitumor Efficacy of Metformin in Prostate Cancer
    Yifan Kong, Yanquan Zhang, Fengyi Mao, Zhuangzhuang Zhang, Zhiguo Li, Ruixin Wang, Jinghui Liu and Xiaoqi Liu
    Mol Cancer Ther December 1 2020 19 (12) 2490-2501; DOI:10.1158/1535-7163.MCT-19-0874

  • Small Molecule Therapeutics
    Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase
    Gabrielle McDonald, Victor Chubukov, John Coco, Kevin Truskowski, Rohini Narayanaswamy, Sung Choe, Mya Steadman, Erin Artin, Anil K. Padyana, Lei Jin, Sebastien Ronseaux, Charles Locuson, Zi-Peng Fan, Tabea Erdmann, Alan Mann, Sebastian Hayes, Mark Fletcher, Kavitha Nellore, Siva Sanjeeva Rao, Hosahalli Subramanya, K. Satish Reddy, Sunil K. Panigrahi, Thomas Antony, Sreevalsam Gopinath, Zhihua Sui, Nelamangala Nagaraja, Lenny Dang, Georg Lenz, Jonathan Hurov, Scott A. Biller, Josh Murtie, Kevin M. Marks and Danielle B. Ulanet
    Mol Cancer Ther December 1 2020 19 (12) 2502-2515; DOI:10.1158/1535-7163.MCT-20-0550

  • Small Molecule Therapeutics
    A Precision Medicine Drug Discovery Pipeline Identifies Combined CDK2 and 9 Inhibition as a Novel Therapeutic Strategy in Colorectal Cancer
    Jason A. Somarelli, Roham Salman Roghani, Ali Sanjari Moghaddam, Beatrice C. Thomas, Gabrielle Rupprecht, Kathryn E. Ware, Erdem Altunel, John B. Mantyh, So Young Kim, Shannon J. McCall, Xiling Shen, Christopher R. Mantyh and David S. Hsu
    Mol Cancer Ther December 1 2020 19 (12) 2516-2527; DOI:10.1158/1535-7163.MCT-20-0454

  • Small Molecule Therapeutics
    Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K–AKT Signaling for the Treatment of Metastatic Osteosarcoma
    Branden A. Smeester, Garrett M. Draper, Nicholas J. Slipek, Alex T. Larsson, Natalie Stratton, Emily J. Pomeroy, Kelsie L. Becklin, Kenta Yamamoto, Kyle B. Williams, Kanut Laoharawee, Joseph J. Peterson, Juan E. Abrahante, Susan K. Rathe, Lauren J. Mills, Margaret R. Crosby, Wendy A. Hudson, Eric P. Rahrmann, David A. Largaespada and Branden S. Moriarity
    Mol Cancer Ther December 1 2020 19 (12) 2528-2541; DOI:10.1158/1535-7163.MCT-20-0369

  • Small Molecule Therapeutics
    A Combination of BRD4 and HDAC3 Inhibitors Synergistically Suppresses Glioma Stem Cell Growth by Blocking GLI1/IL6/STAT3 Signaling Axis
    Qian Wang, Shengnan Jia, Ding Wang, Xuyang Chen, Dhan V. Kalvakolanu, Hongwu Zheng, Xiaodong Wei, Naiyan Wen, Hang Liang, Baofeng Guo and Ling Zhang
    Mol Cancer Ther December 1 2020 19 (12) 2542-2553; DOI:10.1158/1535-7163.MCT-20-0037

Large Molecule Therapeutics

  • Large Molecule Therapeutics
    An Antibody-Tumor Necrosis Factor Fusion Protein that Synergizes with Oxaliplatin for Treatment of Colorectal Cancer
    Davor Bajic, Kerry Chester and Dario Neri
    Mol Cancer Ther December 1 2020 19 (12) 2554-2563; DOI:10.1158/1535-7163.MCT-19-0729

  • Large Molecule Therapeutics
    A Novel Bispecific Antibody with PD-L1–assisted OX40 Activation for Cancer Treatment
    Zhihui Kuang, Pu Pu, Min Wu, Zhihai Wu, Li Wang, Yiming Li, Shaofei Zhang, Hua Jing, Weiwei Wu, Bingliang Chen and Junjian Liu
    Mol Cancer Ther December 1 2020 19 (12) 2564-2574; DOI:10.1158/1535-7163.MCT-20-0226

  • Large Molecule Therapeutics
    Therapy of Myeloid Leukemia using Novel Bispecific Fusion Proteins Targeting CD45 and 90Y-DOTA
    Johnnie J. Orozco, Aimee L. Kenoyer, Yukang Lin, Shyril O'Steen, Rosario Guel, Margaret E. Nartea, Alexandra H. Hernandez, Mark D. Hylarides, Darrell R. Fisher, Ethan R. Balkin, Donald K. Hamlin, D. Scott Wilbur, Kelly D. Orcutt, K. Dane Wittrup, Damian J. Green, Ajay K. Gopal, Brian G. Till, Brenda Sandmaier, Oliver W. Press and John M. Pagel
    Mol Cancer Ther December 1 2020 19 (12) 2575-2584; DOI:10.1158/1535-7163.MCT-20-0306

  • Large Molecule Therapeutics
    RANKL-Targeted Combination Therapy with Osteoprotegerin Variant Devoid of TRAIL Binding Exerts Biphasic Effects on Skeletal Remodeling and Antitumor Immunity
    Hong Wang, Reading Ashton, Jonathan A. Hensel, Joo Hyoung Lee, Vinayak Khattar, Yong Wang, Jessy S. Deshane and Selvarangan Ponnazhagan
    Mol Cancer Ther December 1 2020 19 (12) 2585-2597; DOI:10.1158/1535-7163.MCT-20-0378

  • Large Molecule Therapeutics
    Anti-S100A4 Antibody Therapy Is Efficient in Treating Aggressive Prostate Cancer and Reversing Immunosuppression: Serum and Biopsy S100A4 as a Clinical Predictor
    Arsheed A. Ganaie, Adrian P. Mansini, Tabish Hussain, Arpit Rao, Hifzur R. Siddique, Ashraf Shabaneh, Marina G. Ferrari, Paari Murugan, Jörg Klingelhöfer, Jinhua Wang, Noona Ambartsumian, Christopher A. Warlick, Badrinath R. Konety and Mohammad Saleem
    Mol Cancer Ther December 1 2020 19 (12) 2598-2611; DOI:10.1158/1535-7163.MCT-20-0410

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

  • Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers | AuthorChoice
    Survival Implications of the Relationship between Tissue versus Circulating Tumor DNA TP53 Mutations—A Perspective from a Real-World Precision Medicine Cohort
    Shai Rosenberg, Ryosuke Okamura, Shumei Kato, Thierry Soussi and Razelle Kurzrock
    Mol Cancer Ther December 1 2020 19 (12) 2612-2620; DOI:10.1158/1535-7163.MCT-20-0097

Cancer Biology and Translational Studies

  • Cancer Biology and Translational Studies
    Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
    Jeremy J.P. Shaw, Timothy L. Boyer, Emily Venner, Patrick J. Beck, Tristen Slamowitz, Tara Caste, Alexandra Hickman, Michael H. Raymond, Pedro Costa-Pinheiro, Mark J. Jameson, Todd E. Fox and Mark Kester
    Mol Cancer Ther December 1 2020 19 (12) 2621-2633; DOI:10.1158/1535-7163.MCT-20-0182

  • Cancer Biology and Translational Studies
    Molecular Characterization of Appendiceal Goblet Cell Carcinoid
    Hiroyuki Arai, Yasmine Baca, Francesca Battaglin, Natsuko Kawanishi, Jingyuan Wang, Shivani Soni, Wu Zhang, Joshua Millstein, Curtis Johnston, Richard M. Goldberg, Philip A. Philip, Andreas Seeber, Joanne Xiu, Jimmy J. Hwang, Anthony F. Shields, John L. Marshall, W. Michael Korn and Heinz-Josef Lenz
    Mol Cancer Ther December 1 2020 19 (12) 2634-2640; DOI:10.1158/1535-7163.MCT-20-0318

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Molecular Cancer Therapeutics: 19 (12)
December 2020
Volume 19, Issue 12
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Issue Highlights

  • Emerging CAR-T Cell Therapy for the Treatment of Triple-Negative Breast Cancer
  • Repurposing of a Thromboxane Receptor Inhibitor Based on a Novel Role in Metastasis Identified by Phenome-Wide Association Study
  • Glutaminase Inhibitors Induce Thiol-Mediated Oxidative Stress and Radiosensitization in Treatment-Resistant Cervical Cancers
  • An Antibody-Tumor Necrosis Factor Fusion Protein that Synergizes with Oxaliplatin for Treatment of Colorectal Cancer

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  • Single-cell RNA-seq to Uncover Metastatic Targets in PDAC
  • Sialoglycan mAb for Cancer Immunotherapy
  • Anti-KIT DNA Aptamer Labeling in GIST
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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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