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Molecular Cancer Therapeutics
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Review

Ion Channels and Their Role in the Pathophysiology of Gliomas

Takeshi Takayasu, Kaoru Kurisu, Yoshua Esquenazi and Leomar Y. Ballester
Takeshi Takayasu
1Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston, Houston, Texas.
2Department of Neurosurgery, Institute of Biomedical and Health Sciences, Hiroshima University, Higashihiroshima, Hiroshima, Japan.
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Kaoru Kurisu
2Department of Neurosurgery, Institute of Biomedical and Health Sciences, Hiroshima University, Higashihiroshima, Hiroshima, Japan.
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Yoshua Esquenazi
3Vivian L. Smith Department of Neurosurgery, The University of Texas Health Science Center at Houston, Medical School, Houston, Texas.
4Memorial Hermann Hospital-TMC, Houston, Texas.
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  • ORCID record for Yoshua Esquenazi
  • For correspondence: leomar.y.ballester@uth.tmc.edu Yoshua.EsquenaziLevy@uth.tmc.edu
Leomar Y. Ballester
1Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston, Houston, Texas.
3Vivian L. Smith Department of Neurosurgery, The University of Texas Health Science Center at Houston, Medical School, Houston, Texas.
4Memorial Hermann Hospital-TMC, Houston, Texas.
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  • For correspondence: leomar.y.ballester@uth.tmc.edu Yoshua.EsquenaziLevy@uth.tmc.edu
DOI: 10.1158/1535-7163.MCT-19-0929 Published October 2020
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Abstract

Malignant gliomas are the most common primary central nervous system tumors and their prognosis is very poor. In recent years, ion channels have been demonstrated to play important roles in tumor pathophysiology such as regulation of gene expression, cell migration, and cell proliferation. In this review, we summarize the current knowledge on the role of ion channels on the development and progression of gliomas. Cell volume changes through the regulation of ion flux, accompanied by water flux, are essential for migration and invasion. Signaling pathways affected by ion channel activity play roles in cell survival and cell proliferation. Moreover, ion channels are involved in glioma-related seizures, sensitivity to chemotherapy, and tumor metabolism. Ion channels are potential targets for the treatment of these lethal tumors. Despite our increased understanding of the contributions of ion channels to glioma biology, this field remains poorly studied. This review summarizes the current literature on this important topic.

Footnotes

  • Note: Supplementary data for this article are available at Molecular Cancer Therapeutics Online (http://mct.aacrjournals.org/).

  • Mol Cancer Ther 2020;19:1959–69

  • Received October 10, 2019.
  • Revision received March 24, 2020.
  • Accepted August 6, 2020.
  • Published first October 2, 2020.
  • ©2020 American Association for Cancer Research.
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Molecular Cancer Therapeutics: 19 (10)
October 2020
Volume 19, Issue 10
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Ion Channels and Their Role in the Pathophysiology of Gliomas
Takeshi Takayasu, Kaoru Kurisu, Yoshua Esquenazi and Leomar Y. Ballester
Mol Cancer Ther October 1 2020 (19) (10) 1959-1969; DOI: 10.1158/1535-7163.MCT-19-0929

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Ion Channels and Their Role in the Pathophysiology of Gliomas
Takeshi Takayasu, Kaoru Kurisu, Yoshua Esquenazi and Leomar Y. Ballester
Mol Cancer Ther October 1 2020 (19) (10) 1959-1969; DOI: 10.1158/1535-7163.MCT-19-0929
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  • Article
    • Abstract
    • Introduction
    • Ion Channels
    • Ion Channels and Glioma Invasion/Migration
    • Ion Channels and Glioma Proliferation
    • Ion Channels in Glioma Stem-like Cells
    • Ion Channels and Glioma-related Epilepsy
    • Ion Channels and Sensitivity to Chemotherapy
    • Ion Channels and Glioma Metabolism
    • Ion Channels and Other Biological Processes
    • Ion Channel Expression and Glioma Prognosis
    • Conclusion
    • Disclosure of Potential Conflicts of Interest
    • Acknowledgments
    • Footnotes
    • References
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Molecular Cancer Therapeutics
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