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Molecular Cancer Therapeutics
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Small Molecule Therapeutics

A Novel Small Molecule Targets Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer

Zhenyu Yang, Dan Wang, James K. Johnson, Laura E. Pascal, Keita Takubo, Raghunandan Avula, Anish Bhaswanth Chakka, Jianhua Zhou, Wei Chen, Mingming Zhong, Qiong Song, Hui Ding, Zeyu Wu, Uma R. Chandran, Taber S. Maskrey, Joel B. Nelson, Peter Wipf and Zhou Wang
Zhenyu Yang
1Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P.R. China.
2The Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
3Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Dan Wang
3Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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James K. Johnson
4Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania.
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Laura E. Pascal
3Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Keita Takubo
4Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania.
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Raghunandan Avula
5Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania.
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Anish Bhaswanth Chakka
5Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania.
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Jianhua Zhou
3Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Wei Chen
3Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Mingming Zhong
3Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Qiong Song
3Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
6Key Laboratory of Longevity and Aging-Related Diseases, Guangxi Medical University, Ministry of Education, Nanning, Guangxi, P.R. China.
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Hui Ding
3Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Zeyu Wu
3Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Uma R. Chandran
5Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania.
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Taber S. Maskrey
4Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania.
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Joel B. Nelson
3Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
7UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Peter Wipf
4Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania.
7UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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  • For correspondence: wangz2@upmc.edu pwipf@pitt.edu
Zhou Wang
3Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
7UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
8Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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  • For correspondence: wangz2@upmc.edu pwipf@pitt.edu
DOI: 10.1158/1535-7163.MCT-19-0489 Published January 2020
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ARTICLE USAGE: September 2019 to January 2021

AbstractFull-text HTMLPDF
Total32764081021

Cited By

Article Information

Volume 19, Issue 1, pp. 75-88

DOI 
https://doi.org/10.1158/1535-7163.MCT-19-0489
PubMed 
31554654

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received May 7, 2019
  • Revision received August 8, 2019
  • Accepted September 17, 2019
  • Published first September 25, 2019.

Article Versions

  • Previous version (September 25, 2019 - 07:23).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2019 American Association for Cancer Research.

Author Information

  1. Zhenyu Yang1,2,3,
  2. Dan Wang3,
  3. James K. Johnson4,
  4. Laura E. Pascal3,
  5. Keita Takubo4,
  6. Raghunandan Avula5,
  7. Anish Bhaswanth Chakka5,
  8. Jianhua Zhou3,
  9. Wei Chen3,
  10. Mingming Zhong3,
  11. Qiong Song3,6,
  12. Hui Ding3,
  13. Zeyu Wu3,
  14. Uma R. Chandran5,
  15. Taber S. Maskrey4,
  16. Joel B. Nelson3,7,
  17. Peter Wipf4,7,*, and
  18. Zhou Wang3,7,8,*
  1. 1Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P.R. China.
  2. 2The Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
  3. 3Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  4. 4Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania.
  5. 5Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania.
  6. 6Key Laboratory of Longevity and Aging-Related Diseases, Guangxi Medical University, Ministry of Education, Nanning, Guangxi, P.R. China.
  7. 7UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  8. 8Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  1. ↵*Corresponding Authors:
    Zhou Wang, University of Pittsburgh School of Medicine, 5200 Centre Avenue, Suite G40, Pittsburgh, PA 15232. Phone: 412-623-3903; Fax: 412-623-3904; E-mail: wangz2{at}upmc.edu; and Peter Wipf, 758 CHVRN Chevron Science Center, 219 Parkman Avenue, Pittsburgh, PA 15260. E-mail: pwipf{at}pitt.edu
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Molecular Cancer Therapeutics: 19 (1)
January 2020
Volume 19, Issue 1
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A Novel Small Molecule Targets Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer
Zhenyu Yang, Dan Wang, James K. Johnson, Laura E. Pascal, Keita Takubo, Raghunandan Avula, Anish Bhaswanth Chakka, Jianhua Zhou, Wei Chen, Mingming Zhong, Qiong Song, Hui Ding, Zeyu Wu, Uma R. Chandran, Taber S. Maskrey, Joel B. Nelson, Peter Wipf and Zhou Wang
Mol Cancer Ther January 1 2020 (19) (1) 75-88; DOI: 10.1158/1535-7163.MCT-19-0489

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A Novel Small Molecule Targets Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer
Zhenyu Yang, Dan Wang, James K. Johnson, Laura E. Pascal, Keita Takubo, Raghunandan Avula, Anish Bhaswanth Chakka, Jianhua Zhou, Wei Chen, Mingming Zhong, Qiong Song, Hui Ding, Zeyu Wu, Uma R. Chandran, Taber S. Maskrey, Joel B. Nelson, Peter Wipf and Zhou Wang
Mol Cancer Ther January 1 2020 (19) (1) 75-88; DOI: 10.1158/1535-7163.MCT-19-0489
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