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Molecular Cancer Therapeutics
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Small Molecule Therapeutics

Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer

Xiaoyun Tang, Melinda Wuest, Matthew G.K. Benesch, Jennifer Dufour, YuanYuan Zhao, Jonathan M. Curtis, Alain Monjardet, Bertrand Heckmann, David Murray, Frank Wuest and David N. Brindley
Xiaoyun Tang
1Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
2Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, Alberta, Canada.
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Melinda Wuest
2Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, Alberta, Canada.
3Division of Oncologic Imaging, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.
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Matthew G.K. Benesch
1Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
2Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, Alberta, Canada.
4Discipline of Surgery, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.
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  • ORCID record for Matthew G.K. Benesch
Jennifer Dufour
3Division of Oncologic Imaging, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.
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YuanYuan Zhao
5Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
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Jonathan M. Curtis
5Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
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  • ORCID record for Jonathan M. Curtis
Alain Monjardet
6Galapagos RMV, Parc Biocitech, Romainville, France.
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Bertrand Heckmann
6Galapagos RMV, Parc Biocitech, Romainville, France.
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David Murray
2Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, Alberta, Canada.
7Division of Experimental Oncology, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.
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Frank Wuest
2Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, Alberta, Canada.
3Division of Oncologic Imaging, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.
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David N. Brindley
1Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
2Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, Alberta, Canada.
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  • For correspondence: david.brindley@ualberta.ca
DOI: 10.1158/1535-7163.MCT-19-0386 Published January 2020
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Article Information

Volume 19, Issue 1, pp. 63-74

DOI 
https://doi.org/10.1158/1535-7163.MCT-19-0386
PubMed 
31548293

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received April 9, 2019
  • Revision received August 7, 2019
  • Accepted September 13, 2019
  • Published first September 23, 2019.

Article Versions

  • Previous version (September 23, 2019 - 12:11).
  • Previous version (December 18, 2019 - 08:04).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2019 American Association for Cancer Research.

Author Information

  1. Xiaoyun Tang1,2,
  2. Melinda Wuest2,3,
  3. Matthew G.K. Benesch1,2,4,
  4. Jennifer Dufour3,
  5. YuanYuan Zhao5,
  6. Jonathan M. Curtis5,
  7. Alain Monjardet6,
  8. Bertrand Heckmann6,
  9. David Murray2,7,
  10. Frank Wuest2,3, and
  11. David N. Brindley1,2,*
  1. 1Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
  2. 2Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, Alberta, Canada.
  3. 3Division of Oncologic Imaging, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.
  4. 4Discipline of Surgery, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.
  5. 5Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
  6. 6Galapagos RMV, Parc Biocitech, Romainville, France.
  7. 7Division of Experimental Oncology, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.
  1. ↵*Corresponding Author:
    David N. Brindley, University of Alberta, 357 Heritage Medical Research Centre, Edmonton, Alberta T6G 2S2, Canada. Phone: 780-492-2078; Fax: 780-492-3383; E-mail: david.brindley{at}ualberta.ca
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Molecular Cancer Therapeutics: 19 (1)
January 2020
Volume 19, Issue 1
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Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Xiaoyun Tang, Melinda Wuest, Matthew G.K. Benesch, Jennifer Dufour, YuanYuan Zhao, Jonathan M. Curtis, Alain Monjardet, Bertrand Heckmann, David Murray, Frank Wuest and David N. Brindley
Mol Cancer Ther January 1 2020 (19) (1) 63-74; DOI: 10.1158/1535-7163.MCT-19-0386

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Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
Xiaoyun Tang, Melinda Wuest, Matthew G.K. Benesch, Jennifer Dufour, YuanYuan Zhao, Jonathan M. Curtis, Alain Monjardet, Bertrand Heckmann, David Murray, Frank Wuest and David N. Brindley
Mol Cancer Ther January 1 2020 (19) (1) 63-74; DOI: 10.1158/1535-7163.MCT-19-0386
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