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Molecular Cancer Therapeutics
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Cancer Biology and Translational Studies

Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors

Vindhya Udhane, Cristina Maranto, David T. Hoang, Lei Gu, Andrew Erickson, Savita Devi, Pooja G. Talati, Anjishnu Banerjee, Kenneth A. Iczkowski, Kenneth Jacobsohn, William A. See, Tuomas Mirtti, Deepak Kilari and Marja T. Nevalainen
Vindhya Udhane
1Department of Pathology, Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
2Department of Pharmacology and Toxicology, Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
3Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
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Cristina Maranto
1Department of Pathology, Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
2Department of Pharmacology and Toxicology, Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
3Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
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David T. Hoang
4Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
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Lei Gu
4Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
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Andrew Erickson
5Department of Pathology, Medicum, University of Helsinki, Helsinki, Finland.
6Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.
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Savita Devi
1Department of Pathology, Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
2Department of Pharmacology and Toxicology, Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
3Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
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Pooja G. Talati
4Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
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Anjishnu Banerjee
3Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
7Institute for Health and Equity, Medical College of Wisconsin, Milwaukee, Wisconsin.
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Kenneth A. Iczkowski
1Department of Pathology, Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
3Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
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Kenneth Jacobsohn
3Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
8Department of Urology and Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
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William A. See
3Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
8Department of Urology and Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
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Tuomas Mirtti
5Department of Pathology, Medicum, University of Helsinki, Helsinki, Finland.
6Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.
9Department of Pathology, HUSLAB and Helsinki University Hospital, Helsinki, Finland.
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Deepak Kilari
3Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
10Department of Medicine, Medical College of Wisconsin and Milwaukee VA Medical Center, Milwaukee, Wisconsin.
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Marja T. Nevalainen
1Department of Pathology, Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
2Department of Pharmacology and Toxicology, Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
3Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
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  • For correspondence: mnevalainen@mcw.edu
DOI: 10.1158/1535-7163.MCT-19-0508 Published January 2020
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Article Information

Volume 19, Issue 1, pp. 231-246

DOI 
https://doi.org/10.1158/1535-7163.MCT-19-0508
PubMed 
31548294

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received May 14, 2019
  • Revision received August 16, 2019
  • Accepted September 17, 2019
  • Published first September 23, 2019.

Article Versions

  • Previous version (September 23, 2019 - 12:11).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2019 American Association for Cancer Research.

Author Information

  1. Vindhya Udhane1,2,3,#,
  2. Cristina Maranto1,2,3,#,
  3. David T. Hoang4,
  4. Lei Gu4,
  5. Andrew Erickson5,6,
  6. Savita Devi1,2,3,
  7. Pooja G. Talati4,
  8. Anjishnu Banerjee3,7,
  9. Kenneth A. Iczkowski1,3,
  10. Kenneth Jacobsohn3,8,
  11. William A. See3,8,
  12. Tuomas Mirtti5,6,9,
  13. Deepak Kilari3,10, and
  14. Marja T. Nevalainen1,2,3,*
  1. 1Department of Pathology, Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
  2. 2Department of Pharmacology and Toxicology, Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
  3. 3Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
  4. 4Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
  5. 5Department of Pathology, Medicum, University of Helsinki, Helsinki, Finland.
  6. 6Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.
  7. 7Institute for Health and Equity, Medical College of Wisconsin, Milwaukee, Wisconsin.
  8. 8Department of Urology and Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
  9. 9Department of Pathology, HUSLAB and Helsinki University Hospital, Helsinki, Finland.
  10. 10Department of Medicine, Medical College of Wisconsin and Milwaukee VA Medical Center, Milwaukee, Wisconsin.
  1. ↵*Corresponding Author:
    Marja T. Nevalainen, Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53266. Phone: 414-955-2103; Fax: 414-955-6059; E-mail: mnevalainen{at}mcw.edu
  1. ↵#V. Udhane and C. Maranto contributed equally to this article.

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Molecular Cancer Therapeutics: 19 (1)
January 2020
Volume 19, Issue 1
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Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors
Vindhya Udhane, Cristina Maranto, David T. Hoang, Lei Gu, Andrew Erickson, Savita Devi, Pooja G. Talati, Anjishnu Banerjee, Kenneth A. Iczkowski, Kenneth Jacobsohn, William A. See, Tuomas Mirtti, Deepak Kilari and Marja T. Nevalainen
Mol Cancer Ther January 1 2020 (19) (1) 231-246; DOI: 10.1158/1535-7163.MCT-19-0508

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Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors
Vindhya Udhane, Cristina Maranto, David T. Hoang, Lei Gu, Andrew Erickson, Savita Devi, Pooja G. Talati, Anjishnu Banerjee, Kenneth A. Iczkowski, Kenneth Jacobsohn, William A. See, Tuomas Mirtti, Deepak Kilari and Marja T. Nevalainen
Mol Cancer Ther January 1 2020 (19) (1) 231-246; DOI: 10.1158/1535-7163.MCT-19-0508
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