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Molecular Cancer Therapeutics
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Large Molecule Therapeutics

Minicircle DNA-Engineered CAR T Cells Suppressed Tumor Growth in Mice

Jinsheng Han, Fei Gao, Songsong Geng, Xueshuai Ye, Tie Wang, Pingping Du, Ziqi Cai, Zexian Fu, Zhilong Zhao, Long Shi, Qingxia Li and Jianhui Cai
Jinsheng Han
1Department of Surgery, Hebei Medical University, Shijiazhuang, Hebei, China.
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Fei Gao
1Department of Surgery, Hebei Medical University, Shijiazhuang, Hebei, China.
2Department of Surgery and Oncology, Hebei General Hospital, Shijiazhuang, Hebei, China.
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Songsong Geng
4Hebei Engineering Technology Research Center for Cell Therapy, Hebei HOFOY Biotech Company Ltd., Shijiazhuang, Hebei, China.
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Xueshuai Ye
1Department of Surgery, Hebei Medical University, Shijiazhuang, Hebei, China.
4Hebei Engineering Technology Research Center for Cell Therapy, Hebei HOFOY Biotech Company Ltd., Shijiazhuang, Hebei, China.
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Tie Wang
4Department of Surgery, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, China.
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Pingping Du
4Hebei Engineering Technology Research Center for Cell Therapy, Hebei HOFOY Biotech Company Ltd., Shijiazhuang, Hebei, China.
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Ziqi Cai
4Hebei Engineering Technology Research Center for Cell Therapy, Hebei HOFOY Biotech Company Ltd., Shijiazhuang, Hebei, China.
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Zexian Fu
4Hebei Engineering Technology Research Center for Cell Therapy, Hebei HOFOY Biotech Company Ltd., Shijiazhuang, Hebei, China.
5Department of Surgery, Affiliated Hospital of Hebei Engineering University, Handan, Hebei, China.
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Zhilong Zhao
4Hebei Engineering Technology Research Center for Cell Therapy, Hebei HOFOY Biotech Company Ltd., Shijiazhuang, Hebei, China.
6Department of Surgery, the Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.
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Long Shi
4Hebei Engineering Technology Research Center for Cell Therapy, Hebei HOFOY Biotech Company Ltd., Shijiazhuang, Hebei, China.
7Department of Oncology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
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Qingxia Li
2Department of Surgery and Oncology, Hebei General Hospital, Shijiazhuang, Hebei, China.
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Jianhui Cai
1Department of Surgery, Hebei Medical University, Shijiazhuang, Hebei, China.
2Department of Surgery and Oncology, Hebei General Hospital, Shijiazhuang, Hebei, China.
4Hebei Engineering Technology Research Center for Cell Therapy, Hebei HOFOY Biotech Company Ltd., Shijiazhuang, Hebei, China.
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  • For correspondence: jianhuicai2001@163.com
DOI: 10.1158/1535-7163.MCT-19-0204 Published January 2020
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ARTICLE USAGE: October 2019 to January 2021

AbstractFull-text HTMLPDF
Total1977176460

Cited By

Article Information

Volume 19, Issue 1, pp. 178-186

DOI 
https://doi.org/10.1158/1535-7163.MCT-19-0204
PubMed 
31582530

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received February 28, 2019
  • Revision received July 4, 2019
  • Accepted September 27, 2019
  • Published first October 3, 2019.

Article Versions

  • Previous version (October 3, 2019 - 07:19).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2019 American Association for Cancer Research.

Author Information

  1. Jinsheng Han1,#,
  2. Fei Gao1,2,#,
  3. Songsong Geng3,
  4. Xueshuai Ye1,3,
  5. Tie Wang4,
  6. Pingping Du3,
  7. Ziqi Cai3,
  8. Zexian Fu3,5,
  9. Zhilong Zhao3,6,
  10. Long Shi3,7,
  11. Qingxia Li2, and
  12. Jianhui Cai1,2,3,*
  1. 1Department of Surgery, Hebei Medical University, Shijiazhuang, Hebei, China.
  2. 2Department of Surgery and Oncology, Hebei General Hospital, Shijiazhuang, Hebei, China.
  3. 4Hebei Engineering Technology Research Center for Cell Therapy, Hebei HOFOY Biotech Company Ltd., Shijiazhuang, Hebei, China.
  4. 4Department of Surgery, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, China.
  5. 5Department of Surgery, Affiliated Hospital of Hebei Engineering University, Handan, Hebei, China.
  6. 6Department of Surgery, the Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.
  7. 7Department of Oncology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  1. ↵*Corresponding Author:
    Jianhui Cai, Hebei Medical University, Shijiazhuang 050017, China. Phone: 15130644888; E-mail: jianhuicai2001{at}163.com
  1. ↵#J. Han and F. Gao contributed equally to this article.

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Molecular Cancer Therapeutics: 19 (1)
January 2020
Volume 19, Issue 1
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Minicircle DNA-Engineered CAR T Cells Suppressed Tumor Growth in Mice
Jinsheng Han, Fei Gao, Songsong Geng, Xueshuai Ye, Tie Wang, Pingping Du, Ziqi Cai, Zexian Fu, Zhilong Zhao, Long Shi, Qingxia Li and Jianhui Cai
Mol Cancer Ther January 1 2020 (19) (1) 178-186; DOI: 10.1158/1535-7163.MCT-19-0204

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Minicircle DNA-Engineered CAR T Cells Suppressed Tumor Growth in Mice
Jinsheng Han, Fei Gao, Songsong Geng, Xueshuai Ye, Tie Wang, Pingping Du, Ziqi Cai, Zexian Fu, Zhilong Zhao, Long Shi, Qingxia Li and Jianhui Cai
Mol Cancer Ther January 1 2020 (19) (1) 178-186; DOI: 10.1158/1535-7163.MCT-19-0204
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