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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

Cover image

Cover image expansion

Chimeric antigen receptor T (CAR T) cells represent a new paradigm in cancer therapy. However, viral-based production of these CAR T cells is laborious and comes at a high cost. Therefore, Cai and colleagues sought to utilize minicircle DNA (mcDNA) to produce CAR T cells without the need for viruses. In the cover image, the authors demonstrate strong expression of PSCA on a prostate xenograft. CAR T cells derived using mcDNA targeted at this PSCA infiltrated the tumor and increased cytokine secretion. Read the article on page 178.

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Molecular Cancer Therapeutics: 19 (1)
January 2020
Volume 19, Issue 1
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Issue Highlights

  • Precision Chemoradiotherapy for HER2 Tumors Using Antibody Conjugates of an Auristatin Derivative with Reduced Cell Permeability
  • A Multifunctional Therapy Approach for Cancer: Targeting Raf1- Mediated Inhibition of Cell Motility, Growth, and Interaction with the Microenvironment
  • Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models
  • The Ongoing Search for Biomarkers of CDK4/6 Inhibitor Responsiveness in Breast Cancer
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Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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