Table of Contents

Small Molecule Therapeutics

• Small Molecule Therapeutics | AuthorChoice

  Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically

  Lucy C. Riches, Antonio G. Trinidad, Gareth Hughes, Gemma N. Jones, Adina M. Hughes, Andrew G. Thomason, Paul Gavine, Andy Cui, Stephanie Ling, Jonathan Stott, Roger Clark, Samantha Peel, Pendeep Gill, Louise M. Goodwin, Aaron Smith, Kurt G. Pike, Bernard Barlaam, Martin Pass, Mark J. O'Connor, Graeme Smith and Elaine B. Cadogan

  Mol Cancer Ther January 1 2020 19 (1) 13-25; DOI:10.1158/1535-7163.MCT-18-1394

  
  
• Small Molecule Therapeutics | AuthorChoice

  The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage–Inducing or Repair–Compromising Therapies in Preclinical Cancer Models

  Antje M. Wengner, Gerhard Siemeister, Ulrich Lücking, Julien Lefranc, Lars Wortmann, Philip Lienau, Benjamin Bader, Ulf Bömer, Dieter Moosmayer, Uwe Eberspächer, Sven Golfier, Christoph A. Schatz, Simon J. Baumgart, Bernard Haendler, Pascale Lejeune, Andreas Schlicker, Franz von Nussbaum, Michael Brands, Karl Ziegelbauer and Dominik Mumberg

  Mol Cancer Ther January 1 2020 19 (1) 26-38; DOI:10.1158/1535-7163.MCT-19-0019

  
  
• Small Molecule Therapeutics | AuthorChoice

  A Multifunctional Therapy Approach for Cancer: Targeting Raf1- Mediated Inhibition of Cell Motility, Growth, and Interaction with the Microenvironment

  Limin Zhang, Abhinandan Pattanayak, Wenqi Li, Hyun-Kyung Ko, Graham Fowler, Ryan Gordon and Raymond Bergan

  Mol Cancer Ther January 1 2020 19 (1) 39-51; DOI:10.1158/1535-7163.MCT-19-0222

  
  
• Small Molecule Therapeutics

  Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis

  Hilary A. Kenny, Madhu Lal-Nag, Min Shen, Betul Kara, Dominik A. Nahotko, Kristen Wroblewski, Sarah Fazal, Siquan Chen, Chun-Yi Chiang, Yen-Ju Chen, Kyle R. Brimacombe, Juan Marugan, Marc Ferrer and Ernst Lengyel

  Mol Cancer Ther January 1 2020 19 (1) 52-62; DOI:10.1158/1535-7163.MCT-19-0052

  
  
• Small Molecule Therapeutics

  Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer

  Xiaoyun Tang, Melinda Wuest, Matthew G.K. Benesch, Jennifer Dufour, YuanYuan Zhao, Jonathan M. Curtis, Alain Monjardet, Bertrand Heckmann, David Murray, Frank Wuest and David N. Brindley

  Mol Cancer Ther January 1 2020 19 (1) 63-74; DOI:10.1158/1535-7163.MCT-19-0386

  
  
• Small Molecule Therapeutics

  A Novel Small Molecule Targets Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer

  Zhenyu Yang, Dan Wang, James K. Johnson, Laura E. Pascal, Keita Takubo, Raghunandan Avula, Anish Bhaswanth Chakka, Jianhua Zhou, Wei Chen, Mingming Zhong, Qiong Song, Hui Ding, Zeyu Wu, Uma R. Chandran, Taber S. Maskrey, Joel B. Nelson, Peter Wipf and Zhou Wang

  Mol Cancer Ther January 1 2020 19 (1) 75-88; DOI:10.1158/1535-7163.MCT-19-0489

  
  
• Small Molecule Therapeutics

  Verticillin A Causes Apoptosis and Reduces Tumor Burden in High-Grade Serous Ovarian Cancer by Inducing DNA Damage

  Amrita Salvi, Chiraz Soumia M. Amrine, Julia R. Austin, KiAundra Kilpatrick, Angela Russo, Daniel Lantvit, Esther Calderon-Gierszal, Zachary Mattes, Cedric J. Pearce, Mark W. Grinstaff, Aaron H. Colby, Nicholas H. Oberlies and Joanna E. Burdette

  Mol Cancer Ther January 1 2020 19 (1) 89-100; DOI:10.1158/1535-7163.MCT-19-0205

  
  
• Small Molecule Therapeutics

  A Novel Salicylanilide Derivative Induces Autophagy Cell Death in Castration-Resistant Prostate Cancer via ER Stress-Activated PERK Signaling Pathway

  Chia-Ling Hsieh, Hsu-Shan Huang, Kuan-Chou Chen, Teigi Saka, Chih-Ying Chiang, Leland W.K. Chung and Shian-Ying Sung

  Mol Cancer Ther January 1 2020 19 (1) 101-111; DOI:10.1158/1535-7163.MCT-19-0387

  
  
• Small Molecule Therapeutics

  Molecular Inhibitor of QSOX1 Suppresses Tumor Growth In Vivo

  Amber L. Fifield, Paul D. Hanavan, Douglas O. Faigel, Eduard Sergienko, Andrey Bobkov, Nathalie Meurice, Joachim L. Petit, Alysia Polito, Thomas R. Caulfield, Erik P. Castle, John A. Copland, Debabrata Mukhopadhyay, Krishnendu Pal, Shamit K. Dutta, Huijun Luo, Thai H. Ho and Douglas F. Lake

  Mol Cancer Ther January 1 2020 19 (1) 112-122; DOI:10.1158/1535-7163.MCT-19-0233

  
  
• Small Molecule Therapeutics

  Synergism between ATM and PARP1 Inhibition Involves DNA Damage and Abrogating the G₂ DNA Damage Checkpoint

  Joyce P.Y. Mak, Hoi Tang Ma and Randy Y.C. Poon

  Mol Cancer Ther January 1 2020 19 (1) 123-134; DOI:10.1158/1535-7163.MCT-19-0474

  
  
• Small Molecule Therapeutics

  Dipyridamole Enhances the Cytotoxicities of Trametinib against Colon Cancer Cells through Combined Targeting of HMGCS1 and MEK Pathway

  Sheng Zhou, Huanji Xu, Qiulin Tang, Hongwei Xia and Feng Bi

  Mol Cancer Ther January 1 2020 19 (1) 135-146; DOI:10.1158/1535-7163.MCT-19-0413

  
  
• Small Molecule Therapeutics

  Dual Inhibition of Angiopoietin-TIE2 and MET Alters the Tumor Microenvironment and Prolongs Survival in a Metastatic Model of Renal Cell Carcinoma

  May Elbanna, Ashley R. Orillion, Nur P. Damayanti, Remi Adelaiye-Ogala, Li Shen, Kiersten Marie Miles, Sreenivasulu Chintala, Eric Ciamporcero, Swathi Ramakrishnan, Sheng-yu Ku, Karen Rex, Sean Caenepeel, Angela Coxon and Roberto Pili

  Mol Cancer Ther January 1 2020 19 (1) 147-156; DOI:10.1158/1535-7163.MCT-18-1202