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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Highlights

  • Highlights
    Selected Articles from This Issue
    Mol Cancer Ther January 1 2020 19 (1) 1-1;

Review

  • Review
    The Ongoing Search for Biomarkers of CDK4/6 Inhibitor Responsiveness in Breast Cancer
    Scott F. Schoninger and Stacy W. Blain
    Mol Cancer Ther January 1 2020 19 (1) 3-12; DOI:10.1158/1535-7163.MCT-19-0253

Small Molecule Therapeutics

  • Small Molecule Therapeutics | AuthorChoice
    Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically
    Lucy C. Riches, Antonio G. Trinidad, Gareth Hughes, Gemma N. Jones, Adina M. Hughes, Andrew G. Thomason, Paul Gavine, Andy Cui, Stephanie Ling, Jonathan Stott, Roger Clark, Samantha Peel, Pendeep Gill, Louise M. Goodwin, Aaron Smith, Kurt G. Pike, Bernard Barlaam, Martin Pass, Mark J. O'Connor, Graeme Smith and Elaine B. Cadogan
    Mol Cancer Ther January 1 2020 19 (1) 13-25; DOI:10.1158/1535-7163.MCT-18-1394

  • Small Molecule Therapeutics | AuthorChoice
    The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage–Inducing or Repair–Compromising Therapies in Preclinical Cancer Models
    Antje M. Wengner, Gerhard Siemeister, Ulrich Lücking, Julien Lefranc, Lars Wortmann, Philip Lienau, Benjamin Bader, Ulf Bömer, Dieter Moosmayer, Uwe Eberspächer, Sven Golfier, Christoph A. Schatz, Simon J. Baumgart, Bernard Haendler, Pascale Lejeune, Andreas Schlicker, Franz von Nussbaum, Michael Brands, Karl Ziegelbauer and Dominik Mumberg
    Mol Cancer Ther January 1 2020 19 (1) 26-38; DOI:10.1158/1535-7163.MCT-19-0019

  • Small Molecule Therapeutics | AuthorChoice
    A Multifunctional Therapy Approach for Cancer: Targeting Raf1- Mediated Inhibition of Cell Motility, Growth, and Interaction with the Microenvironment
    Limin Zhang, Abhinandan Pattanayak, Wenqi Li, Hyun-Kyung Ko, Graham Fowler, Ryan Gordon and Raymond Bergan
    Mol Cancer Ther January 1 2020 19 (1) 39-51; DOI:10.1158/1535-7163.MCT-19-0222

  • Small Molecule Therapeutics
    Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis
    Hilary A. Kenny, Madhu Lal-Nag, Min Shen, Betul Kara, Dominik A. Nahotko, Kristen Wroblewski, Sarah Fazal, Siquan Chen, Chun-Yi Chiang, Yen-Ju Chen, Kyle R. Brimacombe, Juan Marugan, Marc Ferrer and Ernst Lengyel
    Mol Cancer Ther January 1 2020 19 (1) 52-62; DOI:10.1158/1535-7163.MCT-19-0052

  • Small Molecule Therapeutics
    Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer
    Xiaoyun Tang, Melinda Wuest, Matthew G.K. Benesch, Jennifer Dufour, YuanYuan Zhao, Jonathan M. Curtis, Alain Monjardet, Bertrand Heckmann, David Murray, Frank Wuest and David N. Brindley
    Mol Cancer Ther January 1 2020 19 (1) 63-74; DOI:10.1158/1535-7163.MCT-19-0386

  • Small Molecule Therapeutics
    A Novel Small Molecule Targets Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer
    Zhenyu Yang, Dan Wang, James K. Johnson, Laura E. Pascal, Keita Takubo, Raghunandan Avula, Anish Bhaswanth Chakka, Jianhua Zhou, Wei Chen, Mingming Zhong, Qiong Song, Hui Ding, Zeyu Wu, Uma R. Chandran, Taber S. Maskrey, Joel B. Nelson, Peter Wipf and Zhou Wang
    Mol Cancer Ther January 1 2020 19 (1) 75-88; DOI:10.1158/1535-7163.MCT-19-0489

  • Small Molecule Therapeutics
    Verticillin A Causes Apoptosis and Reduces Tumor Burden in High-Grade Serous Ovarian Cancer by Inducing DNA Damage
    Amrita Salvi, Chiraz Soumia M. Amrine, Julia R. Austin, KiAundra Kilpatrick, Angela Russo, Daniel Lantvit, Esther Calderon-Gierszal, Zachary Mattes, Cedric J. Pearce, Mark W. Grinstaff, Aaron H. Colby, Nicholas H. Oberlies and Joanna E. Burdette
    Mol Cancer Ther January 1 2020 19 (1) 89-100; DOI:10.1158/1535-7163.MCT-19-0205

  • Small Molecule Therapeutics
    A Novel Salicylanilide Derivative Induces Autophagy Cell Death in Castration-Resistant Prostate Cancer via ER Stress-Activated PERK Signaling Pathway
    Chia-Ling Hsieh, Hsu-Shan Huang, Kuan-Chou Chen, Teigi Saka, Chih-Ying Chiang, Leland W.K. Chung and Shian-Ying Sung
    Mol Cancer Ther January 1 2020 19 (1) 101-111; DOI:10.1158/1535-7163.MCT-19-0387

  • Small Molecule Therapeutics
    Molecular Inhibitor of QSOX1 Suppresses Tumor Growth In Vivo
    Amber L. Fifield, Paul D. Hanavan, Douglas O. Faigel, Eduard Sergienko, Andrey Bobkov, Nathalie Meurice, Joachim L. Petit, Alysia Polito, Thomas R. Caulfield, Erik P. Castle, John A. Copland, Debabrata Mukhopadhyay, Krishnendu Pal, Shamit K. Dutta, Huijun Luo, Thai H. Ho and Douglas F. Lake
    Mol Cancer Ther January 1 2020 19 (1) 112-122; DOI:10.1158/1535-7163.MCT-19-0233

  • Small Molecule Therapeutics
    Synergism between ATM and PARP1 Inhibition Involves DNA Damage and Abrogating the G2 DNA Damage Checkpoint
    Joyce P.Y. Mak, Hoi Tang Ma and Randy Y.C. Poon
    Mol Cancer Ther January 1 2020 19 (1) 123-134; DOI:10.1158/1535-7163.MCT-19-0474

  • Small Molecule Therapeutics
    Dipyridamole Enhances the Cytotoxicities of Trametinib against Colon Cancer Cells through Combined Targeting of HMGCS1 and MEK Pathway
    Sheng Zhou, Huanji Xu, Qiulin Tang, Hongwei Xia and Feng Bi
    Mol Cancer Ther January 1 2020 19 (1) 135-146; DOI:10.1158/1535-7163.MCT-19-0413

  • Small Molecule Therapeutics
    Dual Inhibition of Angiopoietin-TIE2 and MET Alters the Tumor Microenvironment and Prolongs Survival in a Metastatic Model of Renal Cell Carcinoma
    May Elbanna, Ashley R. Orillion, Nur P. Damayanti, Remi Adelaiye-Ogala, Li Shen, Kiersten Marie Miles, Sreenivasulu Chintala, Eric Ciamporcero, Swathi Ramakrishnan, Sheng-yu Ku, Karen Rex, Sean Caenepeel, Angela Coxon and Roberto Pili
    Mol Cancer Ther January 1 2020 19 (1) 147-156; DOI:10.1158/1535-7163.MCT-18-1202

Large Molecule Therapeutics

  • Large Molecule Therapeutics | AuthorChoice
    Precision Chemoradiotherapy for HER2 Tumors Using Antibody Conjugates of an Auristatin Derivative with Reduced Cell Permeability
    Dina V. Hingorani, Matthew K. Doan, Maria F. Camargo, Joseph Aguilera, Seung M. Song, Donald Pizzo, Daniel J. Scanderbeg, Ezra E.W. Cohen, Andrew M. Lowy, Stephen R. Adams and Sunil J. Advani
    Mol Cancer Ther January 1 2020 19 (1) 157-167; DOI:10.1158/1535-7163.MCT-18-1302

  • Large Molecule Therapeutics
    Efficacy of the Antibody–Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors
    Barbara Akla, Matthieu Broussas, Noureddine Loukili, Alain Robert, Charlotte Beau-Larvor, Martine Malissard, Nicolas Boute, Thierry Champion, Jean-Francois Haeuw, Alain Beck, Michel Perez, Cyrille Dreyfus, Mariya Pavlyuk, Eric Chetaille and Nathalie Corvaia
    Mol Cancer Ther January 1 2020 19 (1) 168-177; DOI:10.1158/1535-7163.MCT-19-0219

  • Large Molecule Therapeutics
    Minicircle DNA-Engineered CAR T Cells Suppressed Tumor Growth in Mice
    Jinsheng Han, Fei Gao, Songsong Geng, Xueshuai Ye, Tie Wang, Pingping Du, Ziqi Cai, Zexian Fu, Zhilong Zhao, Long Shi, Qingxia Li and Jianhui Cai
    Mol Cancer Ther January 1 2020 19 (1) 178-186; DOI:10.1158/1535-7163.MCT-19-0204

  • Large Molecule Therapeutics
    Role of Dimerized C16orf74 in Aggressive Pancreatic Cancer: A Novel Therapeutic Target
    Toshihiro Kushibiki, Toru Nakamura, Masumi Tsuda, Takahiro Tsuchikawa, Koji Hontani, Kazuho Inoko, Mizuna Takahashi, Toshimichi Asano, Keisuke Okamura, Soichi Murakami, Yo Kurashima, Yuma Ebihara, Takehiro Noji, Yoshitsugu Nakanishi, Kimitaka Tanaka, Nako Maishi, Katsunori Sasaki, Woong-Ryeon Park, Toshiaki Shichinohe, Kyoko Hida, Shinya Tanaka and Satoshi Hirano
    Mol Cancer Ther January 1 2020 19 (1) 187-198; DOI:10.1158/1535-7163.MCT-19-0491

Cancer Biology and Translational Studies

  • Cancer Biology and Translational Studies
    ALDH1A1 Contributes to PARP Inhibitor Resistance via Enhancing DNA Repair in BRCA2−/− Ovarian Cancer Cells
    Lu Liu, Shurui Cai, Chunhua Han, Ananya Banerjee, Dayong Wu, Tiantian Cui, Guozhen Xie, Junran Zhang, Xiaoli Zhang, Eric McLaughlin, Ming Yin, Floor J. Backes, Arnab Chakravarti, Yanfang Zheng and Qi-En Wang
    Mol Cancer Ther January 1 2020 19 (1) 199-210; DOI:10.1158/1535-7163.MCT-19-0242

  • Cancer Biology and Translational Studies
    PD-1/PD-L1 Immune Checkpoint Inhibition with Radiation in Bladder Cancer: In Situ and Abscopal Effects
    Alexis Rompré-Brodeur, Surashri Shinde-Jadhav, Mina Ayoub, Ciriaco A. Piccirillo, Jan Seuntjens, Fadi Brimo, Jose Joao Mansure and Wassim Kassouf
    Mol Cancer Ther January 1 2020 19 (1) 211-220; DOI:10.1158/1535-7163.MCT-18-0986

  • Cancer Biology and Translational Studies
    Blockade of Glutathione Metabolism in IDH1-Mutated Glioma
    Xiaoying Tang, Xiao Fu, Yang Liu, Di Yu, Sabrina J. Cai and Chunzhang Yang
    Mol Cancer Ther January 1 2020 19 (1) 221-230; DOI:10.1158/1535-7163.MCT-19-0103

  • Cancer Biology and Translational Studies
    Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors
    Vindhya Udhane, Cristina Maranto, David T. Hoang, Lei Gu, Andrew Erickson, Savita Devi, Pooja G. Talati, Anjishnu Banerjee, Kenneth A. Iczkowski, Kenneth Jacobsohn, William A. See, Tuomas Mirtti, Deepak Kilari and Marja T. Nevalainen
    Mol Cancer Ther January 1 2020 19 (1) 231-246; DOI:10.1158/1535-7163.MCT-19-0508

  • Cancer Biology and Translational Studies | AuthorChoice
    Modulating TAK1 Expression Inhibits YAP and TAZ Oncogenic Functions in Pancreatic Cancer
    Raffaela Santoro, Marco Zanotto, Francesca Simionato, Camilla Zecchetto, Valeria Merz, Chiara Cavallini, Geny Piro, Fabio Sabbadini, Federico Boschi, Aldo Scarpa and Davide Melisi
    Mol Cancer Ther January 1 2020 19 (1) 247-257; DOI:10.1158/1535-7163.MCT-19-0270

  • Cancer Biology and Translational Studies
    Targeting Histone Chaperone FACT Complex Overcomes 5-Fluorouracil Resistance in Colon Cancer
    Heyu Song, Jiping Zeng, Shrabasti Roychoudhury, Pranjal Biswas, Bhopal Mohapatra, Sutapa Ray, Kayvon Dowlatshahi, Jing Wang, Vimla Band, Geoffrey Talmon and Kishor K. Bhakat
    Mol Cancer Ther January 1 2020 19 (1) 258-269; DOI:10.1158/1535-7163.MCT-19-0600

  • Cancer Biology and Translational Studies
    Synergy between EphA2-ILs-DTXp, a Novel EphA2-Targeted Nanoliposomal Taxane, and PD-1 Inhibitors in Preclinical Tumor Models
    Walid S. Kamoun, Anne-Sophie Dugast, James J. Suchy, Stephanie Grabow, Ross B. Fulton, James F. Sampson, Lia Luus, Michael Santiago, Alexander Koshkaryev, Gang Sun, Vasileios Askoxylakis, Eric Tam, Zhaohua Richard Huang, Daryl C. Drummond and Andrew J. Sawyer
    Mol Cancer Ther January 1 2020 19 (1) 270-281; DOI:10.1158/1535-7163.MCT-19-0414

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

  • Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
    ADP-Ribosylation Levels and Patterns Correlate with Gene Expression and Clinical Outcomes in Ovarian Cancers
    Lesley B. Conrad, Ken Y. Lin, Tulip Nandu, Bryan A. Gibson, Jayanthi S. Lea and W. Lee Kraus
    Mol Cancer Ther January 1 2020 19 (1) 282-291; DOI:10.1158/1535-7163.MCT-19-0569

  • Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
    Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models
    Heather M. Moore, Heidi M. Savage, Carol O'Brien, Wei Zhou, Ethan S. Sokol, Michael E. Goldberg, Ciara Metcalfe, Lori S. Friedman, Mark R. Lackner and Timothy R. Wilson
    Mol Cancer Ther January 1 2020 19 (1) 292-303; DOI:10.1158/1535-7163.MCT-19-0284

  • Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
    Pralatrexate in Combination with Oxaliplatin in Advanced Esophagogastric Cancer: A Phase II Trial with Predictive Molecular Correlates
    Usha Malhotra, Sarbajit Mukherjee, Christos Fountzilas, Patrick Boland, Austin Miller, Santosh Patnaik, Kristopher Attwood, Sai Yendamuri, Araba Adjei, Eric Kannisto, Mateusz Opyrchal, Peter Bushunow, Peter Loud, Renuka Iyer and Nikhil Khushalani
    Mol Cancer Ther January 1 2020 19 (1) 304-311; DOI:10.1158/1535-7163.MCT-19-0240

  • Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
    Identification of Expression Profiles Defining Distinct Prognostic Subsets of Radioactive-Iodine Refractory Differentiated Thyroid Cancer from the DECISION Trial
    Jaume Capdevila, Ignacio Matos, Francesco M. Mancuso, Carmela Iglesias, Paolo Nuciforo, Carles Zafon, Hector G. Palmer, Zighereda Ogbah, Laura Muiños, Jorge Hernando, Guillermo Villacampa, Carol E. Peña, Josep Tabernero, Marcia S. Brose, Martin Schlumberger and Ana Vivancos
    Mol Cancer Ther January 1 2020 19 (1) 312-317; DOI:10.1158/1535-7163.MCT-19-0211

Acknowledgment to Reviewers

  • Acknowledgment to Reviewers
    Acknowledgment to Reviewers
    Mol Cancer Ther January 1 2020 19 (1) 318-322; DOI:10.1158/1535-7163.MCT-19-1-reviewers

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Molecular Cancer Therapeutics: 19 (1)
January 2020
Volume 19, Issue 1
  • Table of Contents
  • Table of Contents (PDF)
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  • Editorial Board (PDF)

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Issue Highlights

  • Precision Chemoradiotherapy for HER2 Tumors Using Antibody Conjugates of an Auristatin Derivative with Reduced Cell Permeability
  • A Multifunctional Therapy Approach for Cancer: Targeting Raf1- Mediated Inhibition of Cell Motility, Growth, and Interaction with the Microenvironment
  • Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models
  • The Ongoing Search for Biomarkers of CDK4/6 Inhibitor Responsiveness in Breast Cancer

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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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