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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Mol Cancer Ther September 1 2019 18 (9) 1473-1473;

Review

  • Review | AuthorChoice
    DUBbing Down Translation: The Functional Interaction of Deubiquitinases with the Translational Machinery
    Bandish B. Kapadia and Ronald B. Gartenhaus
    Mol Cancer Ther September 1 2019 18 (9) 1475-1483; DOI:10.1158/1535-7163.MCT-19-0307

Small Molecule Therapeutics

  • Small Molecule Therapeutics
    Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells
    Jothi Anantharajan, Hengbo Zhou, Lingdi Zhang, Taylor Hotz, Melanie Y. Vincent, Melanie A. Blevins, Anna E. Jansson, John Wee Liang Kuan, Elizabeth Yihui Ng, Yee Khoon Yeo, Nithya Baburajendran, Grace Lin, Alvin W. Hung, Joma Joy, Samarjit Patnaik, Juan Marugan, Pratyaydipta Rudra, Debashis Ghosh, Jeffrey Hill, Thomas H. Keller, Rui Zhao, Heide L. Ford and CongBao Kang
    Mol Cancer Ther September 1 2019 18 (9) 1484-1496; DOI:10.1158/1535-7163.MCT-18-1239

  • Small Molecule Therapeutics | AuthorChoice
    Encapsulation of Temozolomide in a Calixarene Nanocapsule Improves Its Stability and Enhances Its Therapeutic Efficacy against Glioblastoma
    Alexander Renziehausen, Antonis D. Tsiailanis, Richard Perryman, Evgenios K. Stylos, Christos Chatzigiannis, Kevin O'Neill, Timothy Crook, Andreas G. Tzakos and Nelofer Syed
    Mol Cancer Ther September 1 2019 18 (9) 1497-1505; DOI:10.1158/1535-7163.MCT-18-1250

  • Small Molecule Therapeutics
    Phenotype-Based Screens with Conformation-Specific Inhibitors Reveal p38 Gamma and Delta as Targets for HCC Polypharmacology
    Jia Xin Yu, Amanda J. Craig, Mary E. Duffy, Carlos Villacorta-Martin, Verónica Miguela, Marina Ruiz de Galarreta, Alexander P. Scopton, Lisa Silber, Andres Y. Maldonado, Alexander Rialdi, Ernesto Guccione, Amaia Lujambio, Augusto Villanueva and Arvin C. Dar
    Mol Cancer Ther September 1 2019 18 (9) 1506-1519; DOI:10.1158/1535-7163.MCT-18-0571

  • Small Molecule Therapeutics
    Cyclin-Dependent Kinase-9 Is a Therapeutic Target in MYC-Expressing Diffuse Large B-Cell Lymphoma
    Taylor Hashiguchi, Nur Bruss, Scott Best, Vi Lam, Olga Danilova, Cody J. Paiva, Joelle Wolf, Erin W. Gilbert, Craig Y. Okada, Prabhjot Kaur, Lisa Drew, Justin Cidado, Peter Hurlin and Alexey V. Danilov
    Mol Cancer Ther September 1 2019 18 (9) 1520-1532; DOI:10.1158/1535-7163.MCT-18-1023

Large Molecule Therapeutics

  • Large Molecule Therapeutics | AuthorChoice
    MEN1309/OBT076, a First-In-Class Antibody–Drug Conjugate Targeting CD205 in Solid Tumors
    Giuseppe Merlino, Alessio Fiascarelli, Mario Bigioni, Alessandro Bressan, Corrado Carrisi, Daniela Bellarosa, Massimiliano Salerno, Rossana Bugianesi, Rosanna Manno, Cristina Bernadó Morales, Joaquin Arribas, Rachel L. Dusek, James E. Ackroyd, Phuoc Huy Pham, Rahel Awdew, Dee Aud, Michael Trang, Carmel M. Lynch, Jonathan Terrett, Keith E. Wilson, Christian Rohlff, Stefano Manzini, Andrea Pellacani and Monica Binaschi
    Mol Cancer Ther September 1 2019 18 (9) 1533-1543; DOI:10.1158/1535-7163.MCT-18-0624

  • Large Molecule Therapeutics
    Antibody-Based Delivery of Cytokine Payloads to Carbonic Anhydrase IX Leads to Cancer Cures in Immunocompetent Tumor-Bearing Mice
    Barbara Ziffels, Marco Stringhini, Philipp Probst, Tim Fugmann, Theo Sturm and Dario Neri
    Mol Cancer Ther September 1 2019 18 (9) 1544-1554; DOI:10.1158/1535-7163.MCT-18-1301

  • Large Molecule Therapeutics
    Anti-GPRC5D/CD3 Bispecific T-Cell–Redirecting Antibody for the Treatment of Multiple Myeloma
    Tatsushi Kodama, Yu Kochi, Waka Nakai, Hideaki Mizuno, Takeshi Baba, Kiyoshi Habu, Noriaki Sawada, Hiroyuki Tsunoda, Takahiro Shima, Kohta Miyawaki, Yoshikane Kikushige, Yasuo Mori, Toshihiro Miyamoto, Takahiro Maeda and Koichi Akashi
    Mol Cancer Ther September 1 2019 18 (9) 1555-1564; DOI:10.1158/1535-7163.MCT-18-1216

Cancer Biology and Translational Studies

  • Cancer Biology and Translational Studies
    Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM
    Andrew McKinney, Olle R. Lindberg, Jane R. Engler, Katharine Y. Chen, Anupam Kumar, Henry Gong, Kan V. Lu, Erin F. Simonds, Timothy F. Cloughesy, Linda M. Liau, Michael Prados, Andrew W. Bollen, Mitchel S. Berger, Joseph T.C. Shieh, C. David James, Theodore P. Nicolaides, William H. Yong, Albert Lai, Monika E. Hegi, William A. Weiss and Joanna J. Phillips
    Mol Cancer Ther September 1 2019 18 (9) 1565-1576; DOI:10.1158/1535-7163.MCT-18-1330

  • Cancer Biology and Translational Studies | AuthorChoice
    Aberrant Expression of ERG Promotes Resistance to Combined PI3K and AR Pathway Inhibition through Maintenance of AR Target Genes
    Ninghui Mao, Dong Gao, Wenhuo Hu, Haley Hieronymus, Shangqian Wang, Young Sun Lee, Cindy Lee, Danielle Choi, Anuradha Gopalan, Yu Chen and Brett S. Carver
    Mol Cancer Ther September 1 2019 18 (9) 1577-1586; DOI:10.1158/1535-7163.MCT-18-1386

  • Cancer Biology and Translational Studies | AuthorChoice
    Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia
    Wai-Kin Chan, Thomas D. Horvath, Lin Tan, Todd Link, Karine G. Harutyunyan, Michael A. Pontikos, Andriy Anishkin, Di Du, Leona A. Martin, Eric Yin, Susan B. Rempe, Sergei Sukharev, Marina Konopleva, John N. Weinstein and Philip L. Lorenzi
    Mol Cancer Ther September 1 2019 18 (9) 1587-1592; DOI:10.1158/1535-7163.MCT-18-1329

  • Cancer Biology and Translational Studies
    Monomer Preference of EGFR Tyrosine Kinase Inhibitors Influences the Synergistic Efficacy of Combination Therapy with Cetuximab
    Ayano Oashi, Hiroyuki Yasuda, Keigo Kobayashi, Tetsuo Tani, Junko Hamamoto, Keita Masuzawa, Tadashi Manabe, Hideki Terai, Shinnosuke Ikemura, Ichiro Kawada, Katsuhiko Naoki and Kenzo Soejima
    Mol Cancer Ther September 1 2019 18 (9) 1593-1601; DOI:10.1158/1535-7163.MCT-18-1036

  • Cancer Biology and Translational Studies
    Cell Death Induced by Cationic Amphiphilic Drugs Depends on Lysosomal Ca2+ Release and Cyclic AMP
    Atul Anand, Bin Liu, Jano Dicroce Giacobini, Kenji Maeda, Mikkel Rohde and Marja Jäättelä
    Mol Cancer Ther September 1 2019 18 (9) 1602-1614; DOI:10.1158/1535-7163.MCT-18-1406

  • Cancer Biology and Translational Studies
    Antileukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia
    Sankaranarayanan Kannan, Marisa J.L. Aitken, Shelley M. Herbrich, Leonard S. Golfman, Mandy G. Hall, Duncan H. Mak, Jared K. Burks, Guangchun Song, Marina Konopleva, Charles G. Mullighan, Joya Chandra and Patrick A. Zweidler-McKay
    Mol Cancer Ther September 1 2019 18 (9) 1615-1627; DOI:10.1158/1535-7163.MCT-18-0706

  • Cancer Biology and Translational Studies | AuthorChoice
    Analysis of the Genomic Landscape in ALK+ NSCLC Patients Identifies Novel Aberrations Associated with Clinical Outcomes
    Mathilde Couëtoux du Tertre, Maud Marques, Lise Tremblay, Nicole Bouchard, Razvan Diaconescu, Normand Blais, Christian Couture, Vincent Pelsser, Hangjun Wang, Valerie Higenell, Luisa Izzi, Karen Gambaro, Cyrla Hoffert, Archana Srivastava, Alan Spatz, Caroline Rousseau, Suzan McNamara, Victor Cohen, Gerald Batist and Jason Agulnik
    Mol Cancer Ther September 1 2019 18 (9) 1628-1636; DOI:10.1158/1535-7163.MCT-19-0105

  • Cancer Biology and Translational Studies
    In Vivo ERK1/2 Reporter Predictively Models Response and Resistance to Combined BRAF and MEK Inhibitors in Melanoma
    Ileine M. Sanchez, Timothy J. Purwin, Inna Chervoneva, Dan A. Erkes, Mai Q. Nguyen, Michael A. Davies, Katherine L. Nathanson, Kristel Kemper, Daniel S. Peeper and Andrew E. Aplin
    Mol Cancer Ther September 1 2019 18 (9) 1637-1648; DOI:10.1158/1535-7163.MCT-18-1056

  • Cancer Biology and Translational Studies
    Aggressive Progression in Glioblastoma Cells through Potentiated Activation of Integrin α5β1 by the Tenascin-C–Derived Peptide TNIIIA2
    Motomichi Fujita, Tetsuya Yamamoto, Takuya Iyoda, Tatsuya Fujisawa, Manabu Sasada, Reo Nagai, Chikako Kudo, Kazuki Otsuka, Sadahiro Kamiya, Hiroaki Kodama and Fumio Fukai
    Mol Cancer Ther September 1 2019 18 (9) 1649-1658; DOI:10.1158/1535-7163.MCT-18-1251

Models and Technologies

  • Models and Technologies
    An EGFR-Induced Drosophila Lung Tumor Model Identifies Alternative Combination Treatments
    Judith Bossen, Karin Uliczka, Line Steen, Roxana Pfefferkorn, Mandy Mong-Quyen Mai, Lia Burkhardt, Michael Spohn, Iris Bruchhaus, Christine Fink, Holger Heine and Thomas Roeder
    Mol Cancer Ther September 1 2019 18 (9) 1659-1668; DOI:10.1158/1535-7163.MCT-19-0168

Editor's Note

  • Editor's Note | Free Article
    Editor's Note: Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs
    Laurence Booth, Jane L. Roberts, Nichola Cruickshanks, Steven Grant, Andrew Poklepovic and Paul Dent
    Mol Cancer Ther September 1 2019 18 (9) 1669-1669; DOI:10.1158/1535-7163.MCT-19-0666

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Molecular Cancer Therapeutics: 18 (9)
September 2019
Volume 18, Issue 9
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Issue Highlights

  • MEN1309/OBT076, a First-In-Class Antibody–Drug Conjugate Targeting CD205 in Solid Tumors
  • DUBbing Down Translation: The Functional Interaction of Deubiquitinases with the Translational Machinery
  • Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells
  • Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM

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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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