Molecular Cancer Therapeutics: 18 (9)

Highlights

Highlights

Highlights of This Issue

Mol Cancer Ther September 1 2019 18 (9) 1473-1473;

Review

Review | AuthorChoice

DUBbing Down Translation: The Functional Interaction of Deubiquitinases with the Translational Machinery

Bandish B. Kapadia and Ronald B. Gartenhaus

Mol Cancer Ther September 1 2019 18 (9) 1475-1483; DOI:10.1158/1535-7163.MCT-19-0307

Small Molecule Therapeutics

Small Molecule Therapeutics

Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells

Jothi Anantharajan, Hengbo Zhou, Lingdi Zhang, Taylor Hotz, Melanie Y. Vincent, Melanie A. Blevins, Anna E. Jansson, John Wee Liang Kuan, Elizabeth Yihui Ng, Yee Khoon Yeo, Nithya Baburajendran, Grace Lin, Alvin W. Hung, Joma Joy, Samarjit Patnaik, Juan Marugan, Pratyaydipta Rudra, Debashis Ghosh, Jeffrey Hill, Thomas H. Keller, Rui Zhao, Heide L. Ford and CongBao Kang

Mol Cancer Ther September 1 2019 18 (9) 1484-1496; DOI:10.1158/1535-7163.MCT-18-1239
Small Molecule Therapeutics | AuthorChoice

Encapsulation of Temozolomide in a Calixarene Nanocapsule Improves Its Stability and Enhances Its Therapeutic Efficacy against Glioblastoma

Alexander Renziehausen, Antonis D. Tsiailanis, Richard Perryman, Evgenios K. Stylos, Christos Chatzigiannis, Kevin O'Neill, Timothy Crook, Andreas G. Tzakos and Nelofer Syed

Mol Cancer Ther September 1 2019 18 (9) 1497-1505; DOI:10.1158/1535-7163.MCT-18-1250
Small Molecule Therapeutics

Phenotype-Based Screens with Conformation-Specific Inhibitors Reveal p38 Gamma and Delta as Targets for HCC Polypharmacology

Jia Xin Yu, Amanda J. Craig, Mary E. Duffy, Carlos Villacorta-Martin, Verónica Miguela, Marina Ruiz de Galarreta, Alexander P. Scopton, Lisa Silber, Andres Y. Maldonado, Alexander Rialdi, Ernesto Guccione, Amaia Lujambio, Augusto Villanueva and Arvin C. Dar

Mol Cancer Ther September 1 2019 18 (9) 1506-1519; DOI:10.1158/1535-7163.MCT-18-0571
Small Molecule Therapeutics

Cyclin-Dependent Kinase-9 Is a Therapeutic Target in MYC-Expressing Diffuse Large B-Cell Lymphoma

Taylor Hashiguchi, Nur Bruss, Scott Best, Vi Lam, Olga Danilova, Cody J. Paiva, Joelle Wolf, Erin W. Gilbert, Craig Y. Okada, Prabhjot Kaur, Lisa Drew, Justin Cidado, Peter Hurlin and Alexey V. Danilov

Mol Cancer Ther September 1 2019 18 (9) 1520-1532; DOI:10.1158/1535-7163.MCT-18-1023

Large Molecule Therapeutics

Large Molecule Therapeutics | AuthorChoice

MEN1309/OBT076, a First-In-Class Antibody–Drug Conjugate Targeting CD205 in Solid Tumors

Giuseppe Merlino, Alessio Fiascarelli, Mario Bigioni, Alessandro Bressan, Corrado Carrisi, Daniela Bellarosa, Massimiliano Salerno, Rossana Bugianesi, Rosanna Manno, Cristina Bernadó Morales, Joaquin Arribas, Arnima Bisht, Angelo Kaplan, Robert Boyd, Uyen T. Do, Sudha Swaminathan, Nickolas Attanasio, San Lin Lou, Rachel L. Dusek, James E. Ackroyd, Phuoc Huy Pham, Rahel Awdew, Dee Aud, Michael Trang, Carmel M. Lynch, Jonathan Terrett, Keith E. Wilson, Christian Rohlff, Stefano Manzini, Andrea Pellacani and Monica Binaschi

Mol Cancer Ther September 1 2019 18 (9) 1533-1543; DOI:10.1158/1535-7163.MCT-18-0624
Large Molecule Therapeutics

Antibody-Based Delivery of Cytokine Payloads to Carbonic Anhydrase IX Leads to Cancer Cures in Immunocompetent Tumor-Bearing Mice

Barbara Ziffels, Marco Stringhini, Philipp Probst, Tim Fugmann, Theo Sturm and Dario Neri

Mol Cancer Ther September 1 2019 18 (9) 1544-1554; DOI:10.1158/1535-7163.MCT-18-1301
Large Molecule Therapeutics

Anti-GPRC5D/CD3 Bispecific T-Cell–Redirecting Antibody for the Treatment of Multiple Myeloma

Tatsushi Kodama, Yu Kochi, Waka Nakai, Hideaki Mizuno, Takeshi Baba, Kiyoshi Habu, Noriaki Sawada, Hiroyuki Tsunoda, Takahiro Shima, Kohta Miyawaki, Yoshikane Kikushige, Yasuo Mori, Toshihiro Miyamoto, Takahiro Maeda and Koichi Akashi

Mol Cancer Ther September 1 2019 18 (9) 1555-1564; DOI:10.1158/1535-7163.MCT-18-1216

Cancer Biology and Translational Studies

Cancer Biology and Translational Studies

Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM

Andrew McKinney, Olle R. Lindberg, Jane R. Engler, Katharine Y. Chen, Anupam Kumar, Henry Gong, Kan V. Lu, Erin F. Simonds, Timothy F. Cloughesy, Linda M. Liau, Michael Prados, Andrew W. Bollen, Mitchel S. Berger, Joseph T.C. Shieh, C. David James, Theodore P. Nicolaides, William H. Yong, Albert Lai, Monika E. Hegi, William A. Weiss and Joanna J. Phillips

Mol Cancer Ther September 1 2019 18 (9) 1565-1576; DOI:10.1158/1535-7163.MCT-18-1330
Cancer Biology and Translational Studies | AuthorChoice

Aberrant Expression of ERG Promotes Resistance to Combined PI3K and AR Pathway Inhibition through Maintenance of AR Target Genes

Ninghui Mao, Dong Gao, Wenhuo Hu, Haley Hieronymus, Shangqian Wang, Young Sun Lee, Cindy Lee, Danielle Choi, Anuradha Gopalan, Yu Chen and Brett S. Carver

Mol Cancer Ther September 1 2019 18 (9) 1577-1586; DOI:10.1158/1535-7163.MCT-18-1386
Cancer Biology and Translational Studies | AuthorChoice

Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia

Wai-Kin Chan, Thomas D. Horvath, Lin Tan, Todd Link, Karine G. Harutyunyan, Michael A. Pontikos, Andriy Anishkin, Di Du, Leona A. Martin, Eric Yin, Susan B. Rempe, Sergei Sukharev, Marina Konopleva, John N. Weinstein and Philip L. Lorenzi

Mol Cancer Ther September 1 2019 18 (9) 1587-1592; DOI:10.1158/1535-7163.MCT-18-1329
Cancer Biology and Translational Studies

Monomer Preference of EGFR Tyrosine Kinase Inhibitors Influences the Synergistic Efficacy of Combination Therapy with Cetuximab

Ayano Oashi, Hiroyuki Yasuda, Keigo Kobayashi, Tetsuo Tani, Junko Hamamoto, Keita Masuzawa, Tadashi Manabe, Hideki Terai, Shinnosuke Ikemura, Ichiro Kawada, Katsuhiko Naoki and Kenzo Soejima

Mol Cancer Ther September 1 2019 18 (9) 1593-1601; DOI:10.1158/1535-7163.MCT-18-1036
Cancer Biology and Translational Studies

Cell Death Induced by Cationic Amphiphilic Drugs Depends on Lysosomal Ca²⁺ Release and Cyclic AMP

Atul Anand, Bin Liu, Jano Dicroce Giacobini, Kenji Maeda, Mikkel Rohde and Marja Jäättelä

Mol Cancer Ther September 1 2019 18 (9) 1602-1614; DOI:10.1158/1535-7163.MCT-18-1406
Cancer Biology and Translational Studies

Antileukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia

Sankaranarayanan Kannan, Marisa J.L. Aitken, Shelley M. Herbrich, Leonard S. Golfman, Mandy G. Hall, Duncan H. Mak, Jared K. Burks, Guangchun Song, Marina Konopleva, Charles G. Mullighan, Joya Chandra and Patrick A. Zweidler-McKay

Mol Cancer Ther September 1 2019 18 (9) 1615-1627; DOI:10.1158/1535-7163.MCT-18-0706
Cancer Biology and Translational Studies | AuthorChoice

Analysis of the Genomic Landscape in ALK+ NSCLC Patients Identifies Novel Aberrations Associated with Clinical Outcomes

Mathilde Couëtoux du Tertre, Maud Marques, Lise Tremblay, Nicole Bouchard, Razvan Diaconescu, Normand Blais, Christian Couture, Vincent Pelsser, Hangjun Wang, Valerie Higenell, Luisa Izzi, Karen Gambaro, Cyrla Hoffert, Archana Srivastava, Alan Spatz, Caroline Rousseau, Suzan McNamara, Victor Cohen, Gerald Batist and Jason Agulnik

Mol Cancer Ther September 1 2019 18 (9) 1628-1636; DOI:10.1158/1535-7163.MCT-19-0105
Cancer Biology and Translational Studies

In Vivo ERK1/2 Reporter Predictively Models Response and Resistance to Combined BRAF and MEK Inhibitors in Melanoma

Ileine M. Sanchez, Timothy J. Purwin, Inna Chervoneva, Dan A. Erkes, Mai Q. Nguyen, Michael A. Davies, Katherine L. Nathanson, Kristel Kemper, Daniel S. Peeper and Andrew E. Aplin

Mol Cancer Ther September 1 2019 18 (9) 1637-1648; DOI:10.1158/1535-7163.MCT-18-1056
Cancer Biology and Translational Studies

Aggressive Progression in Glioblastoma Cells through Potentiated Activation of Integrin α5β1 by the Tenascin-C–Derived Peptide TNIIIA2

Motomichi Fujita, Tetsuya Yamamoto, Takuya Iyoda, Tatsuya Fujisawa, Manabu Sasada, Reo Nagai, Chikako Kudo, Kazuki Otsuka, Sadahiro Kamiya, Hiroaki Kodama and Fumio Fukai

Mol Cancer Ther September 1 2019 18 (9) 1649-1658; DOI:10.1158/1535-7163.MCT-18-1251

Models and Technologies

Models and Technologies

An EGFR-Induced Drosophila Lung Tumor Model Identifies Alternative Combination Treatments

Judith Bossen, Karin Uliczka, Line Steen, Roxana Pfefferkorn, Mandy Mong-Quyen Mai, Lia Burkhardt, Michael Spohn, Iris Bruchhaus, Christine Fink, Holger Heine and Thomas Roeder

Mol Cancer Ther September 1 2019 18 (9) 1659-1668; DOI:10.1158/1535-7163.MCT-19-0168

Editor's Note

Editor's Note | Free Article

Editor's Note: Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs

Laurence Booth, Jane L. Roberts, Nichola Cruickshanks, Steven Grant, Andrew Poklepovic and Paul Dent

Mol Cancer Ther September 1 2019 18 (9) 1669-1669; DOI:10.1158/1535-7163.MCT-19-0666

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Review

Small Molecule Therapeutics

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Cancer Biology and Translational Studies

Models and Technologies

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