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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

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ABOUT THE COVER
The treatment of N0 head and neck squamous cell carcinoma remains controversial between dissecting the neck or watchfully monitoring the condition. To generate a new option, Dr. Tanaka and colleagues developed a urokinase-type plasminogen activator-dependent oncolytic Sendai virus (“Bioknife”). In the cover image, GFP-expressing Bioknife is shown to be present in the tongue after injection into an orthotopic xenograft in mice. The authors further demonstrate Bioknife migrates to the sentinel lymph node where it suppressed lymph node metastasis. Read the full article on page 1430.

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Molecular Cancer Therapeutics: 18 (8)
August 2019
Volume 18, Issue 8
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Issue Highlights

  • EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer
  • Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in KRAS-Mutant Cancers
  • Sentinel Lymph Node–Targeted Therapy by Oncolytic Sendai Virus Suppresses Micrometastasis of Head and Neck Squamous Cell Carcinoma in an Orthotopic Nude Mouse Model
  • Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing
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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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