ABOUT THE COVER
The treatment of N0 head and neck squamous cell carcinoma remains controversial between dissecting the neck or watchfully monitoring the condition. To generate a new option, Dr. Tanaka and colleagues developed a urokinase-type plasminogen activator-dependent oncolytic Sendai virus (“Bioknife”). In the cover image, GFP-expressing Bioknife is shown to be present in the tongue after injection into an orthotopic xenograft in mice. The authors further demonstrate Bioknife migrates to the sentinel lymph node where it suppressed lymph node metastasis. Read the full article on page 1430.