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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

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ABOUT THE COVER
Currently, the recommended therapy for muscle-invasive urothelial cancer includes radical cystectomy with or without chemotherapy. In an attempt to develop an organ-sparing therapy, Berndt-Paetz and colleagues demonstrate the use of photodynamic therapy (PDT) in an orthotopic rat model.  PDT with the near-infrared photosensitizer Tetrahydroporphyrin-Tetratosylat generated inflammation (at center) in the urothelial tumor (top right corner) without damaging the surrounding urothelium (lower left), submucosal tissue (lower left), or bladder smooth muscle (upper left). Their results suggest PDT is worthy of clinical consideration in muscle-invasive urothelial cancer.

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Molecular Cancer Therapeutics: 18 (4)
April 2019
Volume 18, Issue 4
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Issue Highlights

  • TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models
  • Reduction of Muscle-Invasive Tumors by Photodynamic Therapy with Tetrahydroporphyrin-Tetratosylat in an Orthotopic Rat Bladder Cancer Model
  • Direct CDKN2 Modulation of CDK4 Alters Target Engagement of CDK4 Inhibitor Drugs
  • Mouse Strains Influence Clearance and Efficacy of Antibody and Antibody–Drug Conjugate Via Fc–FcγR Interaction
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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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