Molecular Cancer Therapeutics: 18 (4)

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Highlights of This Issue

Mol Cancer Ther April 1 2019 18 (4) 731-731;

Small Molecule Therapeutics

Small Molecule Therapeutics

TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models

Hiroki Irie, Kimihiro Ito, Yayoi Fujioka, Kei Oguchi, Akio Fujioka, Akihiro Hashimoto, Hirokazu Ohsawa, Kenji Tanaka, Kaoru Funabashi, Hikari Araki, Yuichi Kawai, Tadashi Shimamura, Renu Wadhwa, Shuichi Ohkubo and Kenichi Matsuo

Mol Cancer Ther April 1 2019 18 (4) 733-742; DOI:10.1158/1535-7163.MCT-18-1085
Small Molecule Therapeutics

Reduction of Muscle-Invasive Tumors by Photodynamic Therapy with Tetrahydroporphyrin-Tetratosylat in an Orthotopic Rat Bladder Cancer Model

Mandy Berndt-Paetz, Philipp Schulze, Philipp C. Stenglein, Annett Weimann, Qiang Wang, Lars-Christian Horn, Yasser M. Riyad, Jan Griebel, Ralf Hermann, Annegret Glasow, Jens-Uwe Stolzenburg and Jochen Neuhaus

Mol Cancer Ther April 1 2019 18 (4) 743-750; DOI:10.1158/1535-7163.MCT-18-1194
Small Molecule Therapeutics

Genipin Enhances the Therapeutic Effects of Oxaliplatin by Upregulating BIM in Colorectal Cancer

Bo Ram Kim, Yoon A. Jeong, Min Jee Jo, Seong Hye Park, Yoo Jin Na, Jung Lim Kim, Soyeon Jeong, Hye Kyeong Yun, Sanghee Kang, Dae-Hee Lee and Sang Cheul Oh

Mol Cancer Ther April 1 2019 18 (4) 751-761; DOI:10.1158/1535-7163.MCT-18-0196
Small Molecule Therapeutics | AuthorChoice

Inhibition of the Replication Stress Response Is a Synthetic Vulnerability in SCLC That Acts Synergistically in Combination with Cisplatin

Remco Nagel, Ana Teresa Avelar, Nanne Aben, Natalie Proost, Marieke van de Ven, Jan van der Vliet, Miranda Cozijnsen, Hilda de Vries, Lodewyk F. A. Wessels and Anton Berns

Mol Cancer Ther April 1 2019 18 (4) 762-770; DOI:10.1158/1535-7163.MCT-18-0972

Cancer Biology and Translational Studies

Cancer Biology and Translational Studies

Direct CDKN2 Modulation of CDK4 Alters Target Engagement of CDK4 Inhibitor Drugs

Jennifer L. Green, Eric S. Okerberg, Josilyn Sejd, Marta Palafox, Laia Monserrat, Senait Alemayehu, Jiangyue Wu, Maria Sykes, Arwin Aban, Violeta Serra and Tyzoon Nomanbhoy

Mol Cancer Ther April 1 2019 18 (4) 771-779; DOI:10.1158/1535-7163.MCT-18-0755
Cancer Biology and Translational Studies | AuthorChoice

Mouse Strains Influence Clearance and Efficacy of Antibody and Antibody–Drug Conjugate Via Fc–FcγR Interaction

Fu Li, Michelle L. Ulrich, Vincent Feng-Sheng Shih, Julia H. Cochran, Joshua H. Hunter, Lori Westendorf, Jason Neale and Dennis R. Benjamin

Mol Cancer Ther April 1 2019 18 (4) 780-787; DOI:10.1158/1535-7163.MCT-18-0977
Cancer Biology and Translational Studies

CYR61/CCN1 Regulates dCK and CTGF and Causes Gemcitabine-resistant Phenotype in Pancreatic Ductal Adenocarcinoma

Gargi Maity, Arnab Ghosh, Vijayalaxmi Gupta, Inamul Haque, Sandipto Sarkar, Amlan Das, Kakali Dhar, Sneha Bhavanasi, Sumedha S. Gunewardena, Daniel D. Von Hoff, Sanku Mallik, Suman Kambhampati, Sushanta K. Banerjee and Snigdha Banerjee

Mol Cancer Ther April 1 2019 18 (4) 788-800; DOI:10.1158/1535-7163.MCT-18-0899
Cancer Biology and Translational Studies

β-Arrestins Regulate Stem Cell-Like Phenotype and Response to Chemotherapy in Bladder Cancer

Georgios Kallifatidis, Diandra K. Smith, Daley S. Morera, Jie Gao, Martin J. Hennig, James J. Hoy, Richard F. Pearce, Isha R. Dabke, Jiemin Li, Axel S. Merseburger, Markus A. Kuczyk, Vinata B. Lokeshwar and Bal L. Lokeshwar

Mol Cancer Ther April 1 2019 18 (4) 801-811; DOI:10.1158/1535-7163.MCT-18-1167
Cancer Biology and Translational Studies

δ-Catenin Promotes Bevacizumab-Induced Glioma Invasion

Toshihiko Shimizu, Joji Ishida, Kazuhiko Kurozumi, Tomotsugu Ichikawa, Yoshihiro Otani, Tetsuo Oka, Yusuke Tomita, Yasuhiko Hattori, Atsuhito Uneda, Yuji Matsumoto and Isao Date

Mol Cancer Ther April 1 2019 18 (4) 812-822; DOI:10.1158/1535-7163.MCT-18-0138
Cancer Biology and Translational Studies

Nanobody Targeting of Epidermal Growth Factor Receptor (EGFR) Ectodomain Variants Overcomes Resistance to Therapeutic EGFR Antibodies

Joseph Tintelnot, Natalie Baum, Christoph Schultheiß, Friederike Braig, Marie Trentmann, Johannes Finter, William Fumey, Peter Bannas, Boris Fehse, Kristoffer Riecken, Kerstin Schuetze, Carsten Bokemeyer, Thies Rösner, Thomas Valerius, Matthias Peipp, Friedrich Koch-Nolte and Mascha Binder

Mol Cancer Ther April 1 2019 18 (4) 823-833; DOI:10.1158/1535-7163.MCT-18-0849
Cancer Biology and Translational Studies

Phosphatidylinositol-3-kinase (PI3K)/Akt Signaling is Functionally Essential in Myxoid Liposarcoma

Marcel Trautmann, Magdalene Cyra, Ilka Isfort, Birte Jeiler, Arne Krüger, Inga Grünewald, Konrad Steinestel, Bianca Altvater, Claudia Rossig, Susanne Hafner, Thomas Simmet, Jessica Becker, Pierre Åman, Eva Wardelmann, Sebastian Huss and Wolfgang Hartmann

Mol Cancer Ther April 1 2019 18 (4) 834-844; DOI:10.1158/1535-7163.MCT-18-0763
Cancer Biology and Translational Studies | AuthorChoice

EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer

Giulia Martini, Claudia Cardone, Pietro Paolo Vitiello, Valentina Belli, Stefania Napolitano, Teresa Troiani, Davide Ciardiello, Carminia Maria Della Corte, Floriana Morgillo, Nunzia Matrone, Vincenzo Sforza, Gianpaolo Papaccio, Vincenzo Desiderio, Mariel C. Paul, Veronica Moreno-Viedma, Nicola Normanno, Anna Maria Rachiglio, Virginia Tirino, Evaristo Maiello, Tiziana Pia Latiano, Daniele Rizzi, Giuseppe Signoriello, Maria Sibilia, Fortunato Ciardiello and Erika Martinelli

Mol Cancer Ther April 1 2019 18 (4) 845-855; DOI:10.1158/1535-7163.MCT-18-0539
Cancer Biology and Translational Studies

Inhibition of Sphingosine Phosphate Receptor 1 Signaling Enhances the Efficacy of VEGF Receptor Inhibition

Anthony S. Fischl, Xiaoen Wang, Beverly L. Falcon, Rowena Almonte-Baldonado, Diane Bodenmiller, Glenn Evans, Julie Stewart, Takako Wilson, Philip Hipskind, Jason Manro, Mark T. Uhlik, Sudhakar Chintharlapalli, Damien Gerald, David C. Alsop, Laura E. Benjamin and Rupal S. Bhatt

Mol Cancer Ther April 1 2019 18 (4) 856-867; DOI:10.1158/1535-7163.MCT-18-0548

Correction

Correction | Free Article

Correction: Nuclear Epidermal Growth Factor Receptor Is a Functional Molecular Target in Triple-negative Breast Cancer

Toni M. Brand, Mari Iida, Emily F. Dunn, Neha Luthar, Kellie T. Kostopoulos, Kelsey L. Corrigan, Matthew J. Wleklinski, David Yang, Kari B. Wisinski, Ravi Salgia and Deric L. Wheeler

Mol Cancer Ther April 1 2019 18 (4) 868-868; DOI:10.1158/1535-7163.MCT-18-1183

Retraction

Retraction | Free Article

Retraction: Sensitizing Estrogen Receptor–negative Breast Cancer Cells to Tamoxifen with OSU-03012, a Novel Celecoxib-derived Phosphoinositide-dependent Protein Kinase-1/Akt Signaling Inhibitor

Shu-Chuan Weng, Yoko Kashida, Samuel K. Kulp, Dasheng Wang, Robert W. Brueggemeier, Charles L. Shapiro and Ching-Shih Chen

Mol Cancer Ther April 1 2019 18 (4) 869-869; DOI:10.1158/1535-7163.MCT-19-0151

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