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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics

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Large Molecule Therapeutics

Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth

Takeshi Harada, Shinji Matsumoto, Suguru Hirota, Hirokazu Kimura, Shinsuke Fujii, Yuuya Kasahara, Hidetoshi Gon, Toshihiko Yoshida, Tomoo Itoh, Naotsugu Haraguchi, Tsunekazu Mizushima, Takehiro Noda, Hidetoshi Eguchi, Satoshi Nojima, Eiichi Morii, Takumi Fukumoto, Satoshi Obika and Akira Kikuchi
Takeshi Harada
Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Osaka University, Osaka, Japan.
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Shinji Matsumoto
Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Osaka University, Osaka, Japan.
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Suguru Hirota
Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Osaka University, Osaka, Japan.
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Hirokazu Kimura
Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Osaka University, Osaka, Japan.
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Shinsuke Fujii
Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Osaka University, Osaka, Japan.
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Yuuya Kasahara
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
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Hidetoshi Gon
Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
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Toshihiko Yoshida
Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
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Tomoo Itoh
Division of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
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Naotsugu Haraguchi
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
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Tsunekazu Mizushima
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
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Takehiro Noda
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
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Hidetoshi Eguchi
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
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Satoshi Nojima
Department of Pathology, Graduate School of Medicine, Osaka University, Osaka, Japan.
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Eiichi Morii
Department of Pathology, Graduate School of Medicine, Osaka University, Osaka, Japan.
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Takumi Fukumoto
Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
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Satoshi Obika
Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
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Akira Kikuchi
Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Osaka University, Osaka, Japan.
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  • ORCID record for Akira Kikuchi
  • For correspondence: akikuchi@molbiobc.med.osaka-u.ac.jp
DOI: 10.1158/1535-7163.MCT-18-0824 Published March 2019
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ARTICLE USAGE: January 2019 to December 2019

AbstractFull-text HTMLPDF
Total2014134370

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Article Information

Volume 18, Issue 3, pp. 602-612

DOI 
https://doi.org/10.1158/1535-7163.MCT-18-0824
PubMed 
30647122

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received July 26, 2018
  • Revision received October 26, 2018
  • Accepted January 10, 2019
  • Published first January 15, 2019.

Article Versions

  • Previous version (January 15, 2019 - 07:40).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2019 American Association for Cancer Research.

Author Information

  1. Takeshi Harada1,
  2. Shinji Matsumoto1,
  3. Suguru Hirota1,
  4. Hirokazu Kimura1,
  5. Shinsuke Fujii1,
  6. Yuuya Kasahara2,3,
  7. Hidetoshi Gon4,
  8. Toshihiko Yoshida4,
  9. Tomoo Itoh5,
  10. Naotsugu Haraguchi6,
  11. Tsunekazu Mizushima6,
  12. Takehiro Noda6,
  13. Hidetoshi Eguchi6,
  14. Satoshi Nojima7,
  15. Eiichi Morii7,
  16. Takumi Fukumoto4,
  17. Satoshi Obika2,3, and
  18. Akira Kikuchi1,*
  1. 1Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Osaka University, Osaka, Japan.
  2. 2Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
  3. 3National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
  4. 4Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
  5. 5Division of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
  6. 6Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
  7. 7Department of Pathology, Graduate School of Medicine, Osaka University, Osaka, Japan.
  1. ↵*Corresponding Author:
    Akira Kikuchi, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. Phone: 81-6-6879-3410; Fax: 81-6-6879-3419; E-mail: akikuchi{at}molbiobc.med.osaka-u.ac.jp
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Molecular Cancer Therapeutics: 18 (3)
March 2019
Volume 18, Issue 3
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Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth
Takeshi Harada, Shinji Matsumoto, Suguru Hirota, Hirokazu Kimura, Shinsuke Fujii, Yuuya Kasahara, Hidetoshi Gon, Toshihiko Yoshida, Tomoo Itoh, Naotsugu Haraguchi, Tsunekazu Mizushima, Takehiro Noda, Hidetoshi Eguchi, Satoshi Nojima, Eiichi Morii, Takumi Fukumoto, Satoshi Obika and Akira Kikuchi
Mol Cancer Ther March 1 2019 (18) (3) 602-612; DOI: 10.1158/1535-7163.MCT-18-0824

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Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth
Takeshi Harada, Shinji Matsumoto, Suguru Hirota, Hirokazu Kimura, Shinsuke Fujii, Yuuya Kasahara, Hidetoshi Gon, Toshihiko Yoshida, Tomoo Itoh, Naotsugu Haraguchi, Tsunekazu Mizushima, Takehiro Noda, Hidetoshi Eguchi, Satoshi Nojima, Eiichi Morii, Takumi Fukumoto, Satoshi Obika and Akira Kikuchi
Mol Cancer Ther March 1 2019 (18) (3) 602-612; DOI: 10.1158/1535-7163.MCT-18-0824
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