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Molecular Cancer Therapeutics
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Cancer Biology and Translational Studies

Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4

Alejandro Villar-Prados, Sherry Y. Wu, Karem A. Court, Shaolin Ma, Christopher LaFargue, Mamur A. Chowdhury, Margaret I. Engelhardt, Cristina Ivan, Prahlad T. Ram, Ying Wang, Keith Baggerly, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Shyh-Ming Yang, David J. Maloney, Makoto Yoshioka, Jeffrey W. Strovel, Jason Roszik and Anil K. Sood
Alejandro Villar-Prados
1Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
2School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.
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  • ORCID record for Alejandro Villar-Prados
Sherry Y. Wu
3School of Biomedical Sciences, University of Queensland, Queensland, Australia.
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Karem A. Court
1Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Shaolin Ma
1Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Christopher LaFargue
1Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Mamur A. Chowdhury
1Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Margaret I. Engelhardt
4John P. and Kathrine G. McGovern Medical School, The University of Texas, Houston, Texas.
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Cristina Ivan
5Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
6Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Prahlad T. Ram
6Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas.
7Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Ying Wang
8Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Keith Baggerly
8Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Cristian Rodriguez-Aguayo
5Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
6Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Gabriel Lopez-Berestein
5Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
6Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Shyh-Ming Yang
9National Center for Advancing Translational Sciences, NIH, Rockville, Maryland.
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David J. Maloney
9National Center for Advancing Translational Sciences, NIH, Rockville, Maryland.
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Makoto Yoshioka
10ConverGene, Gaithersburg, Maryland.
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Jeffrey W. Strovel
10ConverGene, Gaithersburg, Maryland.
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Jason Roszik
11Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
12Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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  • For correspondence: asood@mdanderson.org jroszik@mdanderson.org
Anil K. Sood
1Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
6Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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  • For correspondence: asood@mdanderson.org jroszik@mdanderson.org
DOI: 10.1158/1535-7163.MCT-18-0365 Published February 2019
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ARTICLE USAGE: November 2018 to April 2021

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Article Information

Volume 18, Issue 2, pp. 421-436

DOI 
https://doi.org/10.1158/1535-7163.MCT-18-0365
PubMed 
30420565

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received April 9, 2018
  • Revision received August 24, 2018
  • Accepted November 6, 2018
  • Published first November 12, 2018.

Article Versions

  • Previous version (November 12, 2018 - 08:05).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2018 American Association for Cancer Research.

Author Information

  1. Alejandro Villar-Prados1,2,
  2. Sherry Y. Wu3,
  3. Karem A. Court1,
  4. Shaolin Ma1,
  5. Christopher LaFargue1,
  6. Mamur A. Chowdhury1,
  7. Margaret I. Engelhardt4,
  8. Cristina Ivan5,6,
  9. Prahlad T. Ram6,7,
  10. Ying Wang8,
  11. Keith Baggerly8,
  12. Cristian Rodriguez-Aguayo5,6,
  13. Gabriel Lopez-Berestein5,6,
  14. Shyh-Ming Yang9,
  15. David J. Maloney9,
  16. Makoto Yoshioka10,
  17. Jeffrey W. Strovel10,
  18. Jason Roszik11,12,*, and
  19. Anil K. Sood1,6,*
  1. 1Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  2. 2School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.
  3. 3School of Biomedical Sciences, University of Queensland, Queensland, Australia.
  4. 4John P. and Kathrine G. McGovern Medical School, The University of Texas, Houston, Texas.
  5. 5Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  6. 6Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  7. 7Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  8. 8Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  9. 9National Center for Advancing Translational Sciences, NIH, Rockville, Maryland.
  10. 10ConverGene, Gaithersburg, Maryland.
  11. 11Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  12. 12Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  1. ↵*Corresponding Authors
    . Anil K. Sood, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1362, Houston, TX 77030. Phone: 713-745-5266; Fax: 713-792-7586; E-mail: asood{at}mdanderson.org; and Jason Roszik, jroszik{at}mdanderson.org
  1. J. Roszik and A.K. Sood contributed equally to this article.

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Molecular Cancer Therapeutics: 18 (2)
February 2019
Volume 18, Issue 2
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Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4
Alejandro Villar-Prados, Sherry Y. Wu, Karem A. Court, Shaolin Ma, Christopher LaFargue, Mamur A. Chowdhury, Margaret I. Engelhardt, Cristina Ivan, Prahlad T. Ram, Ying Wang, Keith Baggerly, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Shyh-Ming Yang, David J. Maloney, Makoto Yoshioka, Jeffrey W. Strovel, Jason Roszik and Anil K. Sood
Mol Cancer Ther February 1 2019 (18) (2) 421-436; DOI: 10.1158/1535-7163.MCT-18-0365

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Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4
Alejandro Villar-Prados, Sherry Y. Wu, Karem A. Court, Shaolin Ma, Christopher LaFargue, Mamur A. Chowdhury, Margaret I. Engelhardt, Cristina Ivan, Prahlad T. Ram, Ying Wang, Keith Baggerly, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Shyh-Ming Yang, David J. Maloney, Makoto Yoshioka, Jeffrey W. Strovel, Jason Roszik and Anil K. Sood
Mol Cancer Ther February 1 2019 (18) (2) 421-436; DOI: 10.1158/1535-7163.MCT-18-0365
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