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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

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ABOUT THE COVER
Abemaciclib, a cyclin-dependent kinase 4 and 6 dual inhibitor, was recently approved for the treatment of breast cancer. However, diarrhea is a common adverse event observed in patients treated with abemaciclib. Therefore, Thibault and colleagues sought to determine if toxicity was due to CDK4/6 inhibition or instead due to secondary pharmacological targets. Shown is an image of in situ hybridization (ISH) of rats administered 120 mg/kg abemaciclib using brown reagent with hematoxylin (blue) background. The representative section demonstrated an increased number of crypt cells staining for Smoc2, consistent and proportional to the elongation of the crypts in rats administered abemaciclib. For details, see article on page 257.

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Molecular Cancer Therapeutics: 18 (2)
February 2019
Volume 18, Issue 2
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Issue Highlights

  • MTORC1/2 Inhibition as a Therapeutic Strategy for PIK3CA Mutant Cancers
  • Circulating Tumor Cells with Stemness and Epithelial-to-Mesenchymal Transition Features Are Chemoresistant and Predictive of Poor Outcome in Metastatic Breast Cancer
  • Genome-Wide Sequencing of Cell-Free DNA Identifies Copy-Number Alterations That Can Be Used for Monitoring Response to Immunotherapy in Cancer Patients
  • AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer
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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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