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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics

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About the Cover

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ABOUT THE COVER
Pancreatic cancer is notoriously difficult to treat. One potential opportunity for targeting pancreatic cancer is through its modified amino acid metabolism. Specifically, depriving arginine-dependent tumor cells of arginine can lead to cell death. To achieve this, a polyethylene glycol (PEG)-conjugated arginine deiminase construct (ADI-PEG20) was previously designed and tested as a monotherapy in clinical studies with limited success. In the cover image, adapted from Figure 3 of the associated manuscript, Singh and colleagues demonstrate ADI-PEG20 radiosensitized pancreatic cancer cells by inducing ER stress (red fluorescence, BIP). Therefore, ADI-PEG20 could be combined with radiation therapy in patients whose tumors are arginine-dependent. Read the full study on page 2381.

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Molecular Cancer Therapeutics: 18 (12)
December 2019
Volume 18, Issue 12
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Issue Highlights

  • FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer
  • Cabozantinib in Combination with Immunotherapy for Advanced Renal Cell Carcinoma and Urothelial Carcinoma: Rationale and Clinical Evidence
  • Aurora A–Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy
  • Acquired Resistance to EGFR TKIs Mediated by TGFβ1/Integrin β3 Signaling in EGFR-Mutant Lung Cancer
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Copyright © 2019 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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