About the Cover
Cover image

ABOUT THE COVER
Pancreatic cancer is notoriously difficult to treat. One potential opportunity for targeting pancreatic cancer is through its modified amino acid metabolism. Specifically, depriving arginine-dependent tumor cells of arginine can lead to cell death. To achieve this, a polyethylene glycol (PEG)-conjugated arginine deiminase construct (ADI-PEG20) was previously designed and tested as a monotherapy in clinical studies with limited success. In the cover image, adapted from Figure 3 of the associated manuscript, Singh and colleagues demonstrate ADI-PEG20 radiosensitized pancreatic cancer cells by inducing ER stress (red fluorescence, BIP). Therefore, ADI-PEG20 could be combined with radiation therapy in patients whose tumors are arginine-dependent. Read the full study on page 2381.