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Molecular Cancer Therapeutics
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Small Molecule Therapeutics

A Novel Therapeutic Induces DEPTOR Degradation in Multiple Myeloma Cells with Resulting Tumor Cytotoxicity

Mario I. Vega, Yijiang Shi, Patrick Frost, Sara Huerta-Yepez, Gabriela Antonio-Andres, Rogelio Hernandez-Pando, Jihye Lee, Michael E. Jung, Joseph F. Gera and Alan Lichtenstein
Mario I. Vega
1Hematology-Oncology, VA West LA-UCLA Medical Center, Los Angeles, California.
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Yijiang Shi
1Hematology-Oncology, VA West LA-UCLA Medical Center, Los Angeles, California.
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Patrick Frost
1Hematology-Oncology, VA West LA-UCLA Medical Center, Los Angeles, California.
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Sara Huerta-Yepez
2Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico.
3Pathology & Laboratory Medicine, UCLA Medical School, Los Angeles, California.
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Gabriela Antonio-Andres
2Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico.
3Pathology & Laboratory Medicine, UCLA Medical School, Los Angeles, California.
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Rogelio Hernandez-Pando
4Patologia Experimental, Instituto Nacional de Ciencas Medicas, CDMX, Mexico.
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Jihye Lee
5Gachon University, Incheon, Korea.
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Michael E. Jung
6Department of Chemistry & Biochemistry, University of California, Los Angeles, California.
7Jonsson Cancer Center, University of California, Los Angeles, California.
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Joseph F. Gera
1Hematology-Oncology, VA West LA-UCLA Medical Center, Los Angeles, California.
7Jonsson Cancer Center, University of California, Los Angeles, California.
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Alan Lichtenstein
1Hematology-Oncology, VA West LA-UCLA Medical Center, Los Angeles, California.
7Jonsson Cancer Center, University of California, Los Angeles, California.
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  • For correspondence: alan.lichtenstein@med.va.gov
DOI: 10.1158/1535-7163.MCT-19-0115 Published October 2019
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Article Information

Volume 18, Issue 10, pp. 1822-1831

DOI 
https://doi.org/10.1158/1535-7163.MCT-19-0115
PubMed 
31395691

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received January 31, 2019
  • Revision received June 19, 2019
  • Accepted July 30, 2019
  • Published first August 8, 2019.

Article Versions

  • Previous version (August 8, 2019 - 06:06).
  • Previous version (September 11, 2019 - 08:10).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2019 American Association for Cancer Research.

Author Information

  1. Mario I. Vega1,
  2. Yijiang Shi1,
  3. Patrick Frost1,
  4. Sara Huerta-Yepez2,3,
  5. Gabriela Antonio-Andres2,3,
  6. Rogelio Hernandez-Pando4,
  7. Jihye Lee5,
  8. Michael E. Jung6,7,
  9. Joseph F. Gera1,7, and
  10. Alan Lichtenstein1,7,*
  1. 1Hematology-Oncology, VA West LA-UCLA Medical Center, Los Angeles, California.
  2. 2Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico.
  3. 3Pathology & Laboratory Medicine, UCLA Medical School, Los Angeles, California.
  4. 4Patologia Experimental, Instituto Nacional de Ciencas Medicas, CDMX, Mexico.
  5. 5Gachon University, Incheon, Korea.
  6. 6Department of Chemistry & Biochemistry, University of California, Los Angeles, California.
  7. 7Jonsson Cancer Center, University of California, Los Angeles, California.
  1. ↵*Corresponding Author:
    Alan Lichtenstein, University of California Los Angeles, 11301 Wilshire Blvd, Bldg 304, Room E1-115, Los Angeles, CA 90073. Phone 310-478-3711, ext. 40021; Fax: 310-268-4508; E-mail: alan.lichtenstein{at}med.va.gov
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Molecular Cancer Therapeutics: 18 (10)
October 2019
Volume 18, Issue 10
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A Novel Therapeutic Induces DEPTOR Degradation in Multiple Myeloma Cells with Resulting Tumor Cytotoxicity
Mario I. Vega, Yijiang Shi, Patrick Frost, Sara Huerta-Yepez, Gabriela Antonio-Andres, Rogelio Hernandez-Pando, Jihye Lee, Michael E. Jung, Joseph F. Gera and Alan Lichtenstein
Mol Cancer Ther October 1 2019 (18) (10) 1822-1831; DOI: 10.1158/1535-7163.MCT-19-0115

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A Novel Therapeutic Induces DEPTOR Degradation in Multiple Myeloma Cells with Resulting Tumor Cytotoxicity
Mario I. Vega, Yijiang Shi, Patrick Frost, Sara Huerta-Yepez, Gabriela Antonio-Andres, Rogelio Hernandez-Pando, Jihye Lee, Michael E. Jung, Joseph F. Gera and Alan Lichtenstein
Mol Cancer Ther October 1 2019 (18) (10) 1822-1831; DOI: 10.1158/1535-7163.MCT-19-0115
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Molecular Cancer Therapeutics
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